Skip directly to search Skip directly to A to Z list Skip directly to site content
CDC Home

Notice to Readers: Availability of Additional Trivalent Inactivated Influenza Vaccine for Adults (Afluria®)

On September 28, 2007, CSL Biotherapies, Inc., (King of Prussia, Pennsylvania) received approval from the Food and Drug Administration for use of Afluria®, a trivalent inactivated influenza vaccine (TIV) administered intramuscularly in persons aged >18 years (1). Afluria can be used for any adult influenza vaccine indication (2).

The addition of Afluria brings to six (five TIVs and one live, attenuated influenza vaccine) the number of seasonal influenza vaccines licensed for the U.S. market. CDC estimates that manufacturers of the six vaccines will supply a record 132 million doses of influenza vaccine for the 2007--08 influenza season.

Afluria is available in a 0.5 mL preservative-free, single-dose, prefilled syringe and in a 5 mL multidose vial containing 10 doses. Thimerosal, a mercury derivative, is added as a preservative to the multidose vial; each 0.5 mL dose contains 24.5 µg of mercury. Additional information is available from the manufacturer's package insert (3) and CSL Biotherapies, Inc., telephone 888-435-8633.


  1. Food and Drug Administration. Additional influenza vaccine approved for upcoming influenza season: approval increases available doses to record level. Rockville, MD: Food and Drug Administration; 2007. Available at
  2. CDC. Prevention and control of influenza: recommendations of the Advisory Committee on Immunization Practices (ACIP), 2007. MMWR 2007;56(No. RR-6).
  3. Afluria [package insert]. King of Prussia, PA: CSL Biotherapies, Inc.; 2007. Available at

Use of trade names and commercial sources is for identification only and does not imply endorsement by the U.S. Department of Health and Human Services.

References to non-CDC sites on the Internet are provided as a service to MMWR readers and do not constitute or imply endorsement of these organizations or their programs by CDC or the U.S. Department of Health and Human Services. CDC is not responsible for the content of pages found at these sites. URL addresses listed in MMWR were current as of the date of publication.

All MMWR HTML versions of articles are electronic conversions from typeset documents. This conversion might result in character translation or format errors in the HTML version. Users are referred to the electronic PDF version ( and/or the original MMWR paper copy for printable versions of official text, figures, and tables. An original paper copy of this issue can be obtained from the Superintendent of Documents, U.S. Government Printing Office (GPO), Washington, DC 20402-9371; telephone: (202) 512-1800. Contact GPO for current prices.

**Questions or messages regarding errors in formatting should be addressed to The U.S. Government's Official Web PortalDepartment of Health and Human Services
Centers for Disease Control and Prevention   1600 Clifton Road Atlanta, GA 30329-4027, USA
800-CDC-INFO (800-232-4636) TTY: (888) 232-6348 - Contact CDC–INFO
A-Z Index
  1. A
  2. B
  3. C
  4. D
  5. E
  6. F
  7. G
  8. H
  9. I
  10. J
  11. K
  12. L
  13. M
  14. N
  15. O
  16. P
  17. Q
  18. R
  19. S
  20. T
  21. U
  22. V
  23. W
  24. X
  25. Y
  26. Z
  27. #