Skip Navigation LinksSkip Navigation Links
Centers for Disease Control and Prevention
Safer Healthier People
Blue White
Blue White
bottom curve
CDC Home Search Health Topics A-Z spacer spacer
Blue curve MMWR spacer

Public Health Dispatch: Outbreak of Poliomyelitis --- Dominican Republic and Haiti, 2000

During July 12--November 18, 2000, 19 persons with acute flaccid paralysis (AFP) were identified in the Dominican Republic, including six laboratory-confirmed cases with poliovirus type 1 isolates. Of the 19 case-patients, 16 (84%) were aged <6 years (range: 9 months--21 years). All case-patients were either unvaccinated (n=14) or inadequately vaccinated (n=5). In Haiti, a single laboratory-confirmed poliovirus type 1 case was reported in an inadequately vaccinated child aged 2 years; paralysis onset was August 30. Despite intensive case-finding activities, no additional cases have been identified.

The outbreak virus is unusual because it is derived from oral poliovirus vaccine (OPV) and has 97% genetic similarity to the parental OPV strain (normally vaccine-derived isolates are >99.5% similar to the parent strain) and appears to have recovered the neurovirulence and transmissibility characteristics of wild poliovirus type 1. In comparison, wild polioviruses normally have <82% genetic similarity to OPV (1). The differences in nucleotide sequences among the outbreak isolates suggest that the virus has been circulating for approximately 2 years in an area where vaccination coverage is very low and that the virus had accumulated genetic changes that restored the essential properties of wild poliovirus.

The ministries of health of the Dominican Republic and Haiti, with the assistance of the Pan American Health Organization and CDC, are investigating the outbreak to determine the extent of spread, evaluate the reasons for the outbreak, and initiate appropriate control measures. The Dominican Republic has started a nationwide mass vaccination campaign with OPV, and three nationwide vaccination rounds with OPV are planned for January, February, and March 2001 in Haiti.

Circulation of OPV-derived polioviruses in areas with very low OPV coverage has been documented in one other setting---type 2 OPV-derived virus circulated in Egypt for an estimated 10 years (1983--1993) and was associated with >30 reported cases (2). Vaccination coverage was very low in the affected areas, and circulation of a vaccine-derived poliovirus stopped when OPV coverage increased. The key factor in controlling circulating OPV-derived viruses and wild polioviruses is achieving and maintaining high vaccination coverage. No evidence for circulation of OPV-derived virus has been found in areas with high coverage.

Since 1991, no cases of polio attributed to wild poliovirus have been detected in the Western Hemisphere. The current outbreak underscores the need for polio-free areas to maintain high coverage with polio vaccine until global polio eradication has been achieved. OPV is safe and effective and recommended for the eradication of polio. All countries should maintain high quality AFP and poliovirus surveillance and accelerate current activities to complete the global eradication of wild polioviruses.

Health-care providers should consider polio as a diagnosis in case-patients with a history of travel to other countries of the Western Hemisphere from the Dominican Republic and Haiti who present with AFP usually accompanied by fever. These possible cases should be investigated properly, including collection of stool samples. Suspected cases should be reported immediately to state and local health departments.

Travelers to the Dominican Republic and Haiti who are not vaccinated adequately should be considered at risk for polio. All travelers should be vaccinated fully against polio according to national vaccination policies (3).*

Reported by: Ministry of Health, Pan American Health Organization, Santo Domingo, Dominican Republic. Ministry of Health, Pan American Health Organization, Port-au-Prince, Haiti. Caribbean Epidemiology Center Laboratory, Pan American Health Organization, Trinidad and Tobago. Div of Vaccines and Immunization, Pan American Health Organization, Washington, DC. Respiratory and Enteric Viruses Br, Div of Viral and Rickettsial Diseases, National Center for Infectious Diseases, and Vaccine Preventable Disease Eradication Div, National Immunization Program, CDC.


  1. Kew OM, Mulders MN, Lipskaya GY, et al. Molecular epidemiology of polioviruses. Sem Virol 1995;6:401--14.
  2. Naguib T, Yang SJ, Pallansch M, Kew O. Prolonged circulation of Sabin 2-derived polioviruses. In: Program and abstracts of progress in polio eradication: vaccination strategies for the end game. Geneva, Switzerland: International Association for Biologicals, 2000.
  3. CDC. Poliomyelitis prevention in the United States: updated recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR 2000;49(no. RR-5).


* Current recommendations for children in the United States include a 4-dose vaccination series with inactivated poliovirus vaccine (IPV) at ages 2, 4, 6--18 months, and 4--6 years. Unvaccinated adults should receive three doses of IPV, the first two doses at intervals of 4--8 weeks and the third dose 6--12 months after the second. If three doses cannot be administered within the recommended intervals before protection is needed, alternative schedules are proposed. For incompletely vaccinated persons, additional IPV doses are recommended to complete a series. Booster doses of IPV may be considered for persons who previously have completed a primary series of polio vaccination and who may be traveling to areas where polio is endemic.

Disclaimer   All MMWR HTML versions of articles are electronic conversions from ASCII text into HTML. This conversion may have resulted in character translation or format errors in the HTML version. Users should not rely on this HTML document, but are referred to the electronic PDF version and/or the original MMWR paper copy for the official text, figures, and tables. An original paper copy of this issue can be obtained from the Superintendent of Documents, U.S. Government Printing Office (GPO), Washington, DC 20402-9371; telephone: (202) 512-1800. Contact GPO for current prices.

**Questions or messages regarding errors in formatting should be addressed to

Page converted: 12/7/2000


Safer, Healthier People

Morbidity and Mortality Weekly Report
Centers for Disease Control and Prevention
1600 Clifton Rd, MailStop E-90, Atlanta, GA 30333, U.S.A


Department of Health
and Human Services

This page last reviewed 5/2/01