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Transmission of Measles Among a Highly Vaccinated School Population -- Anchorage, Alaska, 1998

During August 10-November 23, 1998, 33 confirmed * measles cases were reported to the Anchorage Department of Health and Human Services and the Alaska Department of Health and Social Services (ADHSS). Of these, 26 cases were confirmed by positive rubeola IgM antibody test, and seven met the clinical case definition. This was the largest outbreak of measles in the United States since 1996 (1,2). This report summarizes results of the epidemiologic investigation conducted by ADHSS and underscores the importance of second-dose requirements for measles vaccine.

On August 10, a 4-year-old child (index case) visiting from Japan had rash onset of measles while in Anchorage (Figure_1). The child was hospitalized for 1 day, and measles was diagnosed by positive rubeola IgM enzyme-linked immunosorbent assay. No measles virus cultures were obtained. No cases were reported during the following 3 weeks, when secondary cases would have been expected. On September 5, 26 days after onset of the imported case, a 16-year-old high school student developed measles, confirmed by IgM testing. Subsequently, 15 other students and one teacher at the same high school developed measles during September 14-October 4; 12 cases were laboratory confirmed. In addition, four laboratory-confirmed cases and two clinical cases occurred at six other Anchorage schools; one case-patient attended two schools while infectious (from 7 days before to 4 days after rash onset). Eight other confirmed cases occurred among young adults not associated with schools, and one case occurred in a 2-year-old child.

The 33 case-patients ranged in age from 2 to 28 years (median: 16 years). Twenty-nine case-patients had received at least one dose of measles-containing vaccine (MCV) at or after age 12 months; one person with laboratory-confirmed measles had received two appropriately spaced doses of measles-mumps-rubella vaccine (MMR). No serious complications or deaths were reported.

At the high school where the 17 cases occurred, based on school records, only one of 2186 students had not received at least one dose of MCV before the outbreak; 1057 (49%) had received one dose of MCV, and 1112 (51%) had received two or more doses. Estimated vaccine efficacy for two or more doses of MCV was 100%.

Sequence analysis was conducted on the region coding for the COOH terminus of the nucleoprotein for measles virus cultured from three outbreak cases. All three isolates had identical sequences and were classified as genotype D5 (3). This strain was almost identical to wild measles virus strains circulating in Japan in 1998 and was not related to the strain isolated from an outbreak in Juneau in 1996, the most recent isolate available from Alaska (4).

Before 1996, all students attending public and private schools in Alaska were required to have documentation of a single dose of MCV (or a valid medical or religious exemption). Beginning in September 1996, all students entering kindergarten or first grade were required to have two doses of MCV. As a result, school records indicate that virtually all students in kindergarten through third grade as of fall 1998 had received two doses of MMR. However, the proportion of students in grades 4-12 that had two doses was unknown.

In response to the outbreak, ADHSS issued an emergency order requiring that all Anchorage schoolchildren have two doses of MCV by November 16, 1998 (Figure_1). Subsequently, the order was expanded to require all students in the state to have two doses of MCV by January 4, 1999. Students were vaccinated by their health-care providers and at special clinics conducted in Anchorage schools. By November 17, 98.6% of 49,346 Anchorage School District students had provided documentation of two doses of MCV to their schools.

Reported by: B Chandler, MD, Dept of Health and Human Svcs, Municipality of Anchorage; Alaska State Virology Laboratory, Fairbanks; L Wood, MPA, E Funk, MD, M Beller, MD, J Middaugh, MD, State Epidemiologist, Alaska Dept of Health and Social Svcs. Measles Virus Section, Respiratory and Enteric Diseases Br, Div of Viral and Rickettsial Diseases, National Center for Infectious Diseases; Measles Elimination Activity, Child Vaccine Preventable Diseases Br, Epidemiology and Surveillance Div, National Immunization Program; Div of Applied Public Health Training, Epidemiology Program Office; and an EIS Officer, CDC.

Editorial Note

Editorial Note: The occurrence of this outbreak primarily in one school, despite the extremely high one-dose measles vaccine coverage, demonstrates the importance of school requirements for a second dose of MCV. MCV is highly effective; less than 5% of children who receive one dose fail to develop immunity. However, most children respond to a second dose, and greater than 99% of persons aged greater than or equal to 12 months receiving two or more doses at least 28 days apart develop immunity.

The Advisory Committee on Immunization Practices and the American Academy of Pediatrics recommend that all students from grades kindergarten through 12 have two doses of MCV by 2001 (5,6). As of the 1998-99 school year, state school requirements for two-dose measles vaccination have covered approximately 53% of U.S. schoolchildren (CDC, unpublished data, 1998). The vigorous response by public health and school officials in Anchorage to this outbreak in accelerating second-dose measles vaccination among schoolchildren may have limited the extent of this outbreak and will help prevent future outbreaks in Alaska schools.

Monitoring of viral genotypes is an important component of measles surveillance. Genotyping provided evidence that the Anchorage outbreak was due to importation from Japan; however, no specimens were obtained from the index case. This underscores the importance of obtaining throat and urine specimens from suspected measles cases immediately after rash onset. Although no endemic measles virus is circulating in the United States, outbreaks may continue to occur when imported measles virus is introduced into a high-risk setting (e.g., schools with incomplete second-dose MCV coverage).

References

  1. CDC. Measles -- United States, 1997. MMWR 1998;47:273-6.

  2. CDC. Measles -- United States, 1996, and the interruption of indigenous transmission. MMWR 1997;46:242-6.

  3. World Health Organization. Expanded programme on immunization (EPI) -- standardization of the nomenclature for describing the genetic characteristics of wild-type measles viruses. Wkly Epidemiol Rep 1998;73:265-9.

  4. CDC. Measles outbreak among school-aged children -- Juneau, Alaska, 1996. MMWR 1996;45:777-80.

  5. CDC. Measles, mumps, and rubella -- vaccine use and strategies for elimination of measles, rubella, and congenital rubella syndrome and control of mumps: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR 1998;47(no. RR-8):15-6.

  6. American Academy of Pediatrics. Measles. In: Peter G, ed. 1997 Red book: report of the committee on infectious diseases. 24th ed. Elk Grove Village, Illinois: American Academy of Pediatrics, 1997:348.

    • A confirmed case was laboratory confirmed or met the clinical case definition and was epidemiologically linked to a confirmed case. A clinical case was defined as an illness characterized by generalized rash lasting greater than or equal to 3 days; temperature greater than or equal to 101 F ( greater than or equal to 38.3 C); and either cough, coryza, or conjunctivitis.



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