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Availability of Streptomycin and Para-Aminosalicylic Acid -- United States

Since the fall of 1991, streptomycin (SM) and para-aminosalicylic acid (PAS) (antimicrobial agents used to treat tuberculosis (TB)) have been unavailable in the United States.

Beginning April 13, 1992, for an interim period, a limited supply of these drugs manufactured outside the United States will be available through CDC under an investigational new drug agreement. These drugs will initially be made available only for patients with active TB that is resistant to both isoniazid (INH) and rifampin (RIF) or, if susceptibility testing results are not yet available, for patients with active TB in outbreaks where the predominant strains of Mycobacterium tuberculosis are known to be resistant to INH and RIF.

The Food and Drug Administration has identified U.S. companies that have agreed to manufacture SM and PAS. These drugs are expected to be commercially available later this year.

Clinicians interested in obtaining SM or PAS for their patients should be able to provide an abbreviated medical history and for SM, a recent creatinine serum level measurement. Requests should be directed to CDC's Clinical Research Branch, Division of Tuberculosis Elimination, National Center for Prevention Services, telephone (404) 639-2530.

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