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Notices to Readers NIOSH Alert: Request for Assistance in Preventing Bladder Cancer from Exposure to o-Toluidine and Aniline

CDC's National Institute for Occupational Safety and Health (NIOSH) periodically issues alerts on workplace hazards that have caused death or serious injury to workers. One such alert, Request for Assistance in Preventing Bladder Cancer from Exposure to o-Toluidine and Aniline (1),* presents new evidence that clearly associates exposure to o-toluidine and aniline with an increased risk for bladder cancer in workers. NIOSH concludes that o-toluidine and aniline are potential carcinogens as defined in the Occupational Safety and Health Administration's carcinogen policy (2). Workers and employers are therefore urged to implement the recommendations in this alert to reduce exposure to the lowest feasible concentrations.

o-Toluidine and aniline are aromatic amines used as intermediates in the manufacture of a variety of dyes, pharmaceuticals, pesticides, and chemicals employed in the manufacture of rubber. o-Toluidine is produced or used in the United States by 13 facilities, with onsite quantities ranging from 1000 lbs to 10 million lbs. Aniline manufacture and use in the United States is reported by 62 facilities, with onsite quantities ranging from 100 lbs to 50 million lbs. During 1981--1983, the most recent years for which data are available, an estimated 28,483 workers were potentially exposed to o-toluidine, and 35,781 workers were potentially exposed to aniline (CDC, unpublished data). Primary routes of exposure to these compounds are inhalation and dermal contact.

NIOSH recommends reducing o-toluidine and aniline exposures to the lowest feasible concentrations through hazard awareness, training of workers, and use of engineering controls, good work practices, and personal protective equipment. Reported by: National Institute for Occupational Safety and Health, CDC.


  1. NIOSH. NIOSH alert: request for assistance in preventing bladder cancer from exposure to o-toluidine and aniline. Cincinnati, Ohio: US Department of Health and Human Services, Public Health Service, CDC, 1990; DHHS publication no. (NIOSH)90-116.

  2. Office of the Federal Register. Code of federal regulations: identification, classification, and regulation of potential occupational carcinogens. Washington, DC: National Archives and Records Administration, Office of the Federal Register, 1990. (29 CFR *** 1990). *Single copies of this document are available without charge from the Information Dissemination Section, Division of Standards Development and Technology Transfer, NIOSH, CDC, 4676 Columbia Parkway, Cincinnati, OH 45226; telephone (513) 533-8287.

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