Skip directly to search Skip directly to A to Z list Skip directly to site content
CDC Home

Update: Reye Syndrome Pilot Study -- United States, 1984

The results of a pilot study examining the possible relationship between Reye syndrome and medications were recently reported for 29 Reye syndrome patients and 143 controls (1). An independent expert panel that reviewed hospital records for cases included in this analysis has determined that supplemental laboratory and autopsy results obtained for one additional patient, originally excluded because of insufficient information, are consistent with the diagnosis of Reye syndrome.

Analysis of medication data for the 30 patients, including information obtained for this case and its matched controls, revealed that 28 (93%) of 30 cases (compared with the originally reported 28 (97%) of 29 cases) were exposed to salicylates during antecedent respiratory or chickenpox illnesses (and before a clinically defined onset of Reye syndrome), compared with 28% of emergency room, 23% of inpatient, 59% of school, and 51% of random digit-dialing controls matched for similar antecedent illnesses. The association between Reye syndrome and salicylates remains statistically significant. Reported by the Reye Syndrome Task Force, consisting of members from US Food and Drug Administration, National Institutes of Health, Office of the Assistant Secretary of Health, and CDC.


  1. CDC. Reye syndrome--United States, 1984. MMWR 1985;34:13-6.

Use of trade names and commercial sources is for identification only and does not imply endorsement by the U.S. Department of Health and Human Services.

References to non-CDC sites on the Internet are provided as a service to MMWR readers and do not constitute or imply endorsement of these organizations or their programs by CDC or the U.S. Department of Health and Human Services. CDC is not responsible for the content of pages found at these sites. URL addresses listed in MMWR were current as of the date of publication.

All MMWR HTML versions of articles are electronic conversions from typeset documents. This conversion might result in character translation or format errors in the HTML version. Users are referred to the electronic PDF version ( and/or the original MMWR paper copy for printable versions of official text, figures, and tables. An original paper copy of this issue can be obtained from the Superintendent of Documents, U.S. Government Printing Office (GPO), Washington, DC 20402-9371; telephone: (202) 512-1800. Contact GPO for current prices.

**Questions or messages regarding errors in formatting should be addressed to The U.S. Government's Official Web PortalDepartment of Health and Human Services
Centers for Disease Control and Prevention   1600 Clifton Road Atlanta, GA 30329-4027, USA
800-CDC-INFO (800-232-4636) TTY: (888) 232-6348 - Contact CDC–INFO
A-Z Index
  1. A
  2. B
  3. C
  4. D
  5. E
  6. F
  7. G
  8. H
  9. I
  10. J
  11. K
  12. L
  13. M
  14. N
  15. O
  16. P
  17. Q
  18. R
  19. S
  20. T
  21. U
  22. V
  23. W
  24. X
  25. Y
  26. Z
  27. #