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MMWR Summary of Notifiable Diseases, United States, 1993

The following CDC staff members prepared this report:

Denise T. Koo, M.D., M.P.H. Andrew G. Dean, M.D., M.P.H.

Ruth W. Slade Carol M. Knowles Deborah A. Adams Wanda K. Fortune

Patsy A. Hall Robert F. Fagan Barbara Panter-Connah

Harry R. Holden Gerald F. Jones Clarence Lee Maddox

Division of Surveillance and Epidemiology

Epidemiology Program Office


Consultant Willie J. Anderson

Office of the Vice President for Health Affairs

Emory University


Foreword

MMWR Summary of Notifiable Diseases, United States, 1993

This publication contains summary tables of the official statistics for the occurrence of nationally notifiable diseases in the United States for calendar year 1993. This information is collected and compiled from reports to the National Notifiable Diseases Surveillance System (NNDSS).

Part 1 contains information on morbidity for each of the 49 currently notifiable conditions. In all tables, leprosy is listed as Hansen disease, typhus fever (flea-borne) as murine typhus fever, and typhus fever (tick- borne) as Rocky Mountain spotted fever (RMSF). The tables show the number of cases of notifiable diseases reported to CDC for 1993, as well as the distri- bution of cases by month and geographic location, and by patient's age, race, and ethnicity.

Part 2 contains graphs and maps depicting summary data for many of the notifiable conditions described in tabular form in Part I.

Part 3 includes tables showing the number of cases of notifiable diseases reported to CDC and to the National Office of Vital Statistics since 1944. It also includes a table on deaths associated with specified notifiable diseases reported to the National Center for Health Statistics, CDC, for the period 1982-1991.

Background

As of January 1, 1994, 49 infectious diseases were designated as noti- fiable at the national level. A notifiable disease is one for which regular, frequent, and timely information on individual cases is considered necessary for the prevention and control of the disease. This section briefly sum- marizes the history of national notifiable disease reporting in the United States.

In 1878, Congress authorized the U.S. Public Health Service (PHS) to collect morbidity reports on cholera, smallpox, plague, and yellow fever from U.S. consuls overseas; this information was to be used for instituting quar- antine measures to prevent the introduction and spread of these diseases into the United States. In 1879, a specific Congressional appropriation was made for the collection and publication of reports of these notifiable diseases. The authority for weekly reporting and publication was expanded by Congress in 1893 to include data from states and municipal authorities. To increase the uniformity of the data, Congress enacted a law in 1902 directing the Surgeon General to provide forms for the collection and compilation of data and for the publication of reports at the national level. In 1912, state and territorial health authorities -- in conjunction with PHS -- recommended weekly telegraphic reporting of five infectious diseases and monthly report- ing by letter of 10 additional diseases. The first annual summary of The Notifiable Diseases in 1912 included reports of 10 diseases from 19 states, the District of Columbia, and Hawaii. By 1928, all states, the District of Columbia, Hawaii, and Puerto Rico were participating in national reporting of nearly 30 specified conditions. At their meeting in 1950, the State and Territorial Health Officers authorized a conference of state epidemiologists whose purpose was to determine which diseases should be reported to PHS. CDC assumed responsibility for the collection and publication of data on nation- ally notifiable diseases in 1961.

Public health officials at state health departments and CDC continue to collaborate in determining which diseases should be nationally notifiable; the Council of State and Territorial Epidemiologists (CSTE) makes recommenda- tions annually for additions and deletions to the national notifiable disease list on the basis of CDC suggestions. However, reporting of nationally noti- fiable diseases to CDC by the states is voluntary. Reporting is currently mandated only at the state level. The list of diseases that are considered notifiable, therefore, varies slightly by state. All states generally report the internationally quarantinable diseases (i.e., cholera, plague, and yellow fever) in compliance with the World Health Organization's International Health Regulations.

The list of nationally notifiable diseases is revised periodically. Diseases are added to the list as new pathogens emerge; diseases are deleted as their incidence declines. During 1993, 49 infectious diseases were con- sidered notifiable at the national level and were reported to CDC; 41 were reported on a weekly basis, and eight were reported monthly. CSTE will review the principles of notifiable disease reporting in late fall 1994.

Data Sources

Provisional data on the reported occurrence of notifiable diseases are published routinely in MMWR; these data are compiled in final form in this summary. Notifiable disease reports published in the annual MMWR Summary of Notifiable Diseases are the authoritative and archival counts of cases. Data from surveillance records for selected diseases, which are useful for de- tailed epidemiologic analyses, are published on a periodic basis. Data ap- pearing in those surveillance reports may not agree exactly with reports published in MMWR due to differences in the timing of reports or the source of the data or due to refinements in case definitions.

Data in this summary are primarily derived from electronic reports trans- mitted to the Epidemiology Program Office, CDC, by state and territorial health departments through the National Electronic Telecommunications System for Surveillance (NETSS). Final data for other diseases are from surveillance program records of the CDC programs listed below. Requests for further infor- mation regarding these data should be directed to the appropriate source.

National Center for Health Statistics

Office of Vital and Health Statistics Systems (deaths from

selected notifiable diseases)

National Center for Infectious Diseases

Division of Bacterial and Mycotic Diseases (cholera and toxic-

shock syndrome) Division of HIV/AIDS (human immunodeficiency virus/acquired

immunodeficiency syndrome) Division of Vector-Borne Infectious Diseases (arboviral infec

tions of the central nervous system and plague) Division of Viral and Rickettsial Diseases (animal rabies)

National Center for Prevention Services

Division of Sexually Transmitted Diseases and HIV Prevention

(gonorrhea, syphilis, chancroid, granuloma inguinale, and lymphogranuloma venereum) Division of Tuberculosis Elimination (tuberculosis)

National Immunization Program

Epidemiology and Surveillance Division (poliomyelitis)

Disease totals for the United States, unless otherwise stated, do not include data for American Samoa, Guam, Puerto Rico, the Virgin Islands, and the Commonwealth of the Northern Mariana Islands (CNMI).

Data on notifiable diseases before 1960 are obtained from publications of the National Office of Vital Statistics.

Population estimates for states are based on the July 1, 1993, post- censal estimates made by the U.S. Department of Commerce, Bureau of the Census, Population Division, Population Estimates Branch, Press Release CB93-219.

Population estimates for territories are from the 1990 census, U.S. Department of Commerce, Bureau of the Census, Press Releases CB91-142, 242, 243, 263, and 276.

Rates in the 1993 Summary of Notifiable Diseases were based on data for the U.S. total resident population. However, population data from states in which diseases were not notifiable or not available were excluded from rate calculations.

Interpreting Data

Although the data reported in this summary are important for analyzing disease trends and determining relative disease burdens, these data must be interpreted with caution. Some diseases, such as plague and rabies, that cause severe clinical illness and are associated with serious consequences probably are diagnosed and reported accurately. However, diseases that are clinically mild and infrequently associated with serious consequences (e.g., salmonellosis and mumps) are less likely to be reported. Additionally, sub- clinical cases are seldom detected except in the course of special studies. The degree of completeness of reporting also is influenced by the diagnostic facilities available, the control measures in effect, and the interests and priorities of state and local officials responsible for disease control and surveillance. Finally, factors such as the introduction of new diagnostic tests and the discovery of new disease entities may cause changes in disease reporting that are independent of the true incidence of disease.

Public health surveillance data are published for selected racial and ethnic population groups because these variables may be risk markers for certain notifiable diseases. Risk markers can identify potential risk factors for investigation in future studies. Data on race and ethnicity also can be useful for identifying groups to target for prevention efforts. Year 2000 Objectives for racial and ethnic groups have been established for several of the notifiable diseases.

EXPLANATION OF SYMBOLS USED IN

TABLES, GRAPHS, AND MAPS

Data not available ............................................. NA No reported cases .............................................. - Report of disease not required

by state health department (not notifiable) ............................................. NN

1993 HIGHLIGHTS FOR SELECTED DISEASES

This section highlights important developments in the reported occur- rences of certain notifiable and non-notifiable infectious diseases. Those diseases that currently are not nationally notifiable are highlighted under the subheading "Emerging Infections."

AIDS

In 1993, the number of AIDS cases reported to CDC increased 127% from the number reported in 1992. The large increase in the number of cases was largely due to changes in the 1993 AIDS surveillance case definition. As of January 1, 1993, HIV-infected persons with additional clinical conditions, as well as those with markers of severe immunosuppression, were defined as having AIDS.

Botulism

In 1993, two restaurant-associated outbreaks of botulism occurred in which unusual vehicles of transmission were implicated. In one of the out- breaks, which occurred in Georgia, the toxin was transmitted by a canned cheese sauce; in the other outbreak in Texas, toxin was transmitted by a dip containing baked potatoes.

Cholera

Epidemics of cholera caused by a new pathogen, Vibrio cholerae O139, occurred in late 1992 and early 1993 in southern Asia; in the United States, the first recognized case of infection caused by Vibrio cholerae 0139 occurred during 1993 in a California resident who had visited India in January 1993.

Diphtheria

Outbreaks of diphtheria were reported from the Newly Independent States of the former Soviet Union (especially Russia and Ukraine) and Ecuador. No cases were reported last year among U.S. travelers to these countries.

Haemophilus influenzae

The rate of Haemophilus influenzae disease as reported through the National Notifiable Diseases Surveillance System (NNDSS) has continued to decline. Rates decreased 95% between 1987 and 1993. Data collected by active surveillance from selected sites indicate that the decline is primarily in Haemophilus influenzae type b (Hib) disease among children <5 years of age. This decline is associated with the use of the newly licensed Hib conjugate vaccines.

Hepatitis B

The reported incidence of hepatitis B decreased 59% from 1985 through 1993. This decline was caused by decreases in the number of cases reported among homosexual men between 1985 and 1989 (61%) and in the number reported among injecting-drug users from 1989 through 1992 (51%). These decreases are thought to result from an increase in AIDS awareness, which has resulted in behavioral changes (e.g., safer sex and needle-using practices).

Hepatitis, Non-A, Non-B

The steady increase in the number of cases of non-A, non-B hepatitis reported to NNDSS since 1990 is not thought to be caused by an increase in incidence, but rather caused by the screening of blood for the presence of antibody to the hepatitis C virus (anti-HCV, available beginning in May, 1990). Persons testing positive for anti-HCV, regardless of the presence of illness, have been reported as having non-A, non-B hepatitis. Surveillance at sentinel sites has actually shown a steady decrease in the incidence of non- A, non-B hepatitis, with a decline of >50% from 1988 through 1993. This decline is primarily attributable to a 58% decrease in the number of reported cases among injecting-drug users.

Legionnaires' Disease

Although only 1,280 cases of Legionnaires' disease were reported through NNDSS in 1993, data from recent prospective pneumonia studies suggest that between 10,000 and 15,000 cases occur each year.

Lyme Disease

In 1993, the number of cases of Lyme disease reported to CDC nationwide decreased by 15% from 1992. Hunterdon, New Jersey meanwhile experienced an increase in reported cases of Lyme disease from 75 cases in 1992 to 206 cases in 1993; upon investigation, the increase in reported cases was found to be due to both increased reporting by physicians and an increase in disease incidence.

Malaria

In August 1993, three persons without recent bloodborne exposure and who had not recently traveled were diagnosed with Plasmodium falciparum malaria infection in New York City. The results of the epidemiologic investigation suggest local acquisition through mosquito-borne transmission.

Measles

The total number of measles cases reported to CDC in 1993 -- 312 -- was the lowest number ever recorded in the United States. This reduction in reported measles cases may reflect cyclical changes in measles incidence as well as increases in measles vaccination coverage among preschool-aged children, increased use of a second dose of measles vaccine among school- and college-aged persons, and increased efforts to control measles throughout the Western Hemisphere.

Meningococcal disease

Several clusters of group C disease were recognized in 1993, resulting in mass vaccinations with meningococcal vaccine. Because approximately one half of severe meningococcal disease in this country is caused by serogroup B and because the vaccine is only effective for disease caused by serogroups A, C, Y, and W, the clusters illustrate the importance of serogroup determination and reporting for all cases of invasive Neisseria meningitidis.

Mumps

The total number of mumps cases reported in 1993 -- 1,692 -- was the lowest number ever reported in the United States.

Pertussis

The 6,503 pertussis cases reported in the United States in 1993 represent the highest annual total since 1967. Of 1,347 cases of pertussis among children 7 months to 4 years of age with known vaccination status, 630 (46.8%) had received fewer than three doses of DTP vaccine -- the minimum number of doses necessary for clinical protection.

Rubella

The total number of rubella cases reported to the CDC remained low in 1993 (N=192), although the number increased by 19% over the record low number of cases reported in 1992.

Sexually Transmitted Diseases

Nationally, the rates for gonorrhea and primary and secondary syphilis have declined since 1990, reaching low points in 1993 that were below or approaching the Year 2000 Objectives (1) (greater than or equal to 225 cases gonorrhea and greater than or equal to 10 cases primary and secondary syphilis per 100,000 persons). However, rates for both diseases remained higher than the Year 2000 Objectives for certain population subgroups: adolescents and young adults, minorities (especially blacks), and persons living in the southern United States.

Shigella

The number of cases of Shigella reported through NNDSS increased 35% from 1992 to 1993, with increases of 27%-405% reported from nine states. This increase was also reported through the national Shigella surveillance system, which receives reports of laboratory isolates of Shigella through the Public Health Laboratory Information System (PHLIS); 91% of Shigella isolates reported through PHLIS in 1993 were Shigella sonnei.

Tuberculosis

Between 1992 and 1993, the number of reported tuberculosis (TB) cases in the United States decreased from 26,673 to 25,313. This decrease may be associated with the effectiveness of prevention and control measures imple- mented during the period 1989-1993. However, two other factors also may be responsible for the decrease, including a) delayed reporting caused by use of the new TB surveillance reporting form and the change from paper records to a computerized system and b) underreporting because of modification of the AIDS surveillance case definition in January 1993.

EMERGING INFECTIONS

NOTE: The term "emerging infectious diseases" refers to those "infectious diseases whose incidence in humans has increased within the past two decades or threatens to increase in the near future" (2). These can be new or previously unrecognized infectious diseases, reemerging diseases, or infec- tious diseases that have developed resistance to previously effective anti- microbial drugs.

Coccidioidomycosis

The outbreak of coccidioidomycosis in California that began in 1991 continued in 1993. From an annual average number of 428 cases reported per year in California during the period 1981-1990, 1,200 cases were reported in 1991, 4,516 in 1992, and4,137 in 1993, 70% of which were reported from Kern County in central California. Key factors that may be associated with the ongoing outbreak include weather conditions that are conducive to the growth and spread of Coccidioides immitis (e.g., protracted drought followed by heavy rains), activities that disturb the soil and facilitate airborne spread of the organism, and an increasing population of persons who are susceptible to the organism because of migration from areas where coccidoidomycosis is not endemic.

Cryptosporidiosis

In spring 1993, a municipal water supply in Milwaukee, Wisconsin, contaminated with Cryptosporidium caused the largest recognized outbreak of waterborne illness in the history of the United States. More than 400,000 persons became ill, 4,400 of whom required hospitalization.

Escherichia coli O157:H7

In 1993, an outbreak of E. coli O157:H7 affected more than 500 people in four western states, resulting in 56 cases of hemolytic uremic syndrome and four deaths. Because of this outbreak, many clinical laboratories began screening stool samples for E. coli O157:H7, which resulted in the identifi- cation of many more cases and outbreaks. In May 1993, the Council of State and Territorial Epidemiologists (CSTE) passed a resolution recommending that E. coli O157:H7 infection be made reportable by all states and territories.

Group A Streptococcal Disease

During 1993, CDC surveillance for invasive group A streptococcal infec- tions consisted of a passive nationwide surveillance system. This system operated through the collection of isolates from normally sterile sites and the collection of case reports. Although current data on incidence and trends for invasive disease, streptococcal toxic shock syndrome, and necrotizing fasciitis are not available, population-based active surveillance for these infections has begun in several geographic areas and will be expanded in 1994 as part of surveillance for emerging infectious diseases.

Hantavirus Pulmonary Syndrome

Hantavirus Pulmonary Syndrome (HPS), a newly recognized illness charac- terized by an influenza-like prodrome followed by the acute onset of respira- tory failure, was first identified in the southwestern United States in June 1993 during the investigation of a cluster of unexplained deaths. A new hantavirus (Sin Nombre virus) and a rodent reservoir for the virus (the deer mouse {Peromyscus maniculatus}) were identified. As of August 31, 1994, national surveillance for HPS, initiated by CDC in coordination with CSTE, has identified 91 confirmed cases of HPS (with 48 deaths) in 20 states (case fatality rate: 53%).

Drug-Resistant Pneumococcus

The increasing incidence of drug-resistant Streptococcus pneumoniae (DRSP) strains in the United States has created an emerging public health challenge. CDC surveillance data from 1992 indicated that the prevalence of pneumococcal strains that are highly resistant to penicillin increased 60- fold (from 0.02% to 1.3%) when compared with the prevalence of isolates collected from 1979 through 1987. CDC, CSTE, and the infectious diseases and microbiology communities are developingrecommendations for the surveillance of DRSP infections. This surveillance data will be used to determine optimal empiric treatment regimens for pneumococcal infections.

Vancomycin-Resistant Enterococci (VRE)

From 1989 through 1993, the percentage of nosocomial enterococci resis- tant to vancomycin reported from hospitals participating in the National Nosocomial Infections Surveillance System increased from 0.3% to 7.9%. During this period, numerous VRE outbreaks (occurring primarily among immunocom- promised patients) were reported. Because of the public health importance of the emergence of VRE, CDC has published draft Guidelines for Preventing the Spread of Vancomycin Resistance and is conducting studies to assess the effectiveness of these guidelines in preventing disease transmission.

References

  1. Public Health Service. Healthy people 2000: national health promotion and disease prevention objectives -- full report, with commentary. Washing- ton, DC: US Department of Health and Human Services, Public Health Service, 1991:152; DHHS publication no. (PHS)91-50212.

  2. Institute of Medicine. Emerging infections: microbial threats to health in the United States. Washington, DC: National Academy Press, 1992.

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Mumps

Briss PA, Fehrs LJ, Parker RA, et al. Sustained transmission of mumps in a

highly vaccinated population: assessment of primary vaccine failure and waning vaccine-induced immunity. J Infect Dis 1994;169:77-82. CDC. Mumps prevention. MMWR 1989;38(22):388-92,397-400. CDC. Mumps -- United States, 1985-1988. MMWR 1989;38(7):101-5. Hersch BS, Fine PEM, Kent WK, et al. Mumps outbreak in a highly vaccinated

population. J Pediatr 1991;119:187-93.

Murine Typhus Fever

Benenson AS. Control of communicable diseases in man. 15th ed. Washington,

DC: American Public Health Association, 1990. McDade JE, Fishbein DB. Rickettsiaceae: the rickettsiae. In: Laboratory

diagnosis of infectious diseases: principles and practice. Vol II. Viral, rickettsial, and chlamydial diseases. New York: Springer-Verlag, 1988: 864-89. Woodward TE. Murine typhus fever: its clinical and biologic similarity of

epidemic typhus. In: Biology of rickettsial disease. Vol II. Boca Raton, Florida: CRC Press, 1988:79-92.

Pertussis

CDC. Pertussis surveillance -- United States, 1989-1991. MMWR 1992;41(No.

SS-8):11-9. Cherry JD, Brunell PA, Golden GS, et al. Report of the Task Force on Pertus-

sis and Pertussis Immunization, 1988. Pediatrics 1988;81(suppl):S939-84. Strebel PM, Cochi SL, Farizo KM, et al. Pertussis in Missouri: evaluation of

nasopharyngeal culture, direct fluorescent antibody testing and clinical case definitions in the diagnosis of pertussis. Clin Infect Dis 1993;16: 276-85.

Plague

Craven RB, Barnes AM. Plague and tularemia. Infect Dis Clin North Am 1991;5:

165-75. Poland JD. Plague. In: Hoeprich PD, ed. Infectious Diseases. 2nd ed. New

York: Harper and Row, 1989:151;1296-1306.

Poliomyelitis

CDC. Poliomyelitis -- United States, 1975-1984. MMWR 1986;35(11):180-2. Prevots DR, Suter RW, Strebel PM, Weibel RE, Cochi SL. Completeness of

reporting for paralytic poliomyelitis, United States, 1980 through 1991. Archives of Pediatrics and Adolescent Medicine 1994;148:479-85. Strebel PM, Sutter RW, Cochi SL, et al. Epidemiology of poliomyelitis in the

United States: one decade after the last reported case of indigenous wild virus-associated disease. Clin Infect Dis 1992;14:568-79.

Psittacosis

Anonymous. Compendium of chlamydiosis (psitticosis) control, 1994. National

Association of State Public Health Veterinarians, Inc. J Am Vet Med Assoc 1993;203:1673-80. Barnes RC. Laboratory diagnosis of human chlamydial infections. Clin Micro-

biol Rev 1989;2:119-36. Kuritsky JN, Schmid GP, Potter ME, Anderson DC, Kaufmann AF. Psittacosis: a

diagnostic challenge. J Occup Med 1984;26:731-3.

Rabies

Baer G. Natural history of rabies. 2nd ed. Boca Raton, Florida: CRC press,

1991. CDC. Compendium of animal rabies control, 1994. MMWR 1994;43(No. RR-10). CDC. Rabies prevention -- United States, 1991: recommendations of the Immuni-

zation Practices Advisory Committee (ACIP). MMWR 1991;40(No. RR-3). Krebs JW, Strine TW, Childs JE. Rabies surveillance in the United States

during 1992. J Am Vet Med Assoc 1993;203:1718-31.

Rheumatic Fever

Dajani AS. Prevention of rheumatic fever: a statement for health profession-

als by the Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease of the Council on Cardiovascular Disease in the Young, the American Heart Association. Pediatr Infect Dis J 1989;8:263-6. Kaplan EL, Johnson DR, Cleary PP. Group A streptococcal serotypes isolated

from patients and sibling contacts during the resurgence of rheumatic fever in the United States in the mid-1980's. J Infect Dis 1989;1259: 101-3. Veasy GL, Wiedmeier SE, Orsmond GS, et al. Resurgence of acute rheumatic

fever in the intermountain area in the United States. N Engl J Med 1987;316:421-8.

Rocky Mountain Spotted Fever (RMSF)

Burgdorfer W, Anacker FL, eds. Rickettsiae and Rickettsial Diseases. New

York: Academic Press, 1981. McDade JE, Fishbein DB. Rickettsiaceae: the rickettsiae. In: Laboratory

diagnosis of infectious diseases: principles and practice. Vol II. Viral, rickettsial, and chlamydial diseases. New York: Springer-Verlag, 1988: 864-89.

Rubella

CDC. Increase in rubella and congenital rubella syndrome -- United States,

1988-1990. MMWR 1991;40(6):93-9. CDC. Rubella and congenital rubella syndrome -- United States, January 1,

1991-May 7, 1994. MMWR 1994;43(21):391,397-401. CDC. Outbreaks of rubella among the Amish -- United States, 1991. MMWR

1991;40(16):264. CDC. Congenital rubella syndrome among the Amish -- Pennsylvania, 1991-1992.

MMWR 1992;41(26):468-9,475-6. CDC. Rubella prevention: recommendations of the Immunization Practices

Advisory Committee (ACIP). MMWR 1990;39(No. RR-15). Lindegren ML, Fehrs LJ, Hadler SC, Hinman AR. Update: rubella and congenital

rubella syndrome, 1980-1990. Epidemiol Rev 1991;13:341-8.

Salmonellosis

Lee LA, Puhr ND, Maloney EK, Bean NH, Tauxe RV. Increase in antimicrobial-

resistant Salmonella infections in the United States, 1989-1990. J Infect Dis 1994;170:128-34. Mishu B, Griffin PM, Tauxe RV, Cameron DN, Hutcheson RH, Schaffner W. Salmo-

nella enteritidis gastroenteritis transmitted by intact chicken eggs. Ann Intern Med 1991;115:190-4. St. Louis ME, Morse DL, Potter ME, et al. The emergence of grade A eggs as a

major source of Salmonella enteritidis infections: new implications for the control of salmonellosis. JAMA 1988;259:2103-7. Tauxe RV. Salmonella : a postmodern pathogen. Journal of Food Protection

1991;54:563-8.

Shigellosis

Lee LA, Shapiro CN, Hargrett-Bean N, Tauxe RV. Hyperendemic shigellosis in

the United States: a review of surveillance data for 1967-1988. J Infect Dis 1991;164:894-900. Parsonnet J, Greene KD, Gerber AR, et al. Shigella dysenteriae type 1 infec-

tions in U.S. travellers to Mexico. Lancet 1989:543-5. Ries AA, Wells JG, Olivola D, et al. Epidemic Shigella dysenteriae type 1 in

Burundi: panresistance and implications for prevention. J Infect Dis 1994;169:1035-41.

Syphilis

Aral SO, Wasserheit JN, Green SB, Judson FN, Sparling FP. The NIAID/NIH

working group on integrated behavioral research for prevention and control of STDs. Part III: Issues in evaluating behavioral interventions. Sex Transm Dis 1990;17:208-10. CDC. Primary and secondary syphilis -- United States, 1981-1990. MMWR 1991;

40(19):314-5,321-3. CDC. Regional and temporal trends in the surveillance of syphilis, United

States, 1986-1990. MMWR 1991;40(No. SS-3):29-33. CDC. Special focus: surveillance for sexually transmitted diseases. MMWR

1993;42(No. SS-3):13-9.

Tetanus

CDC. Surveillance of tetanus -- United States, 1989-1990. MMWR 1992;41(No.

SS-8):1-9. Sutter RW, Cochi SL, Brink EW, Sirotkin BI. Assessment of vital statistics

and surveillance data for monitoring tetanus mortality, United States, 1979-1984. Am J Epidemiol 1990;131:132-42.

Toxic Shock Syndrome

CDC. Reduced incidence of menstrual toxic shock syndrome -- United States,

1980-1990. MMWR 1990;39(25):421-3. Gaventa S, Reingold AL, Hightower AW, et al. Active surveillance for toxic

shock syndrome in the United States, 1986. Rev Infect Dis 1989;(suppl): S28-34. Schuchat A, Broome CV. Toxic shock syndrome and tampons. Epidemiol Rev

1991;13:99-112.

Trichinosis

Bailey TM, Schantz PM. Trends in the incidence and transmission patterns of

human trichinosis in the United States, 1982-1986. Rev Infect Dis 1990; 12:5-11. Campbell WC (ed.). Trichinella and trichinosis. New York: Plenum Press, 1983. CDC. Trichinosis surveillance -- United States, 1987-1990. MMWR 1991;40(No.

SS-3):35-42. McAuley JB, Michelson MK, Hightower AW, Engeran S, Wintermeyer LA, Schantz

PM. A trichinosis outbreak among Southeast Asian refugees. Am J Epidemiol 1992;135:1404-10.

Tuberculosis

American Thoracic Society/CDC. Treatment of tuberculosis and tuberculosis

infection in adults and children. Am J Respir Crit Care Med 1994;149: 1359-74. CDC. Recommendations for counting reported tuberculosis cases. Atlanta: US

Department of Health and Human Services, Public Health Service, 1977. CDC. Expanded tuberculosis surveillance and tuberculosis morbidity -- United

States, 1993. MMWR 1994;43(20):361-6.

Tularemia

Evans ME, Gregory DW, Schaffner W, McGee ZA. Tularemia: a 30 year experience

with 88 cases. Medicine 1985;64:251-69. Taylor JP, Istre GR, McChesny TC, Satalowich FT, Parker RE, McFarland LM.

Epidemiologic characteristics of human tularemia in the southwest-central states, 1981-1987. Am J Epidemiol 1991;133:1032-8.

Typhoid Fever

CDC. Typhoid immunization: recommendations of the Immunization Practices

Advisory Committee. MMWR 1990;39(No. RR-10). Ryan CA, Hargrett-Bean NT, Blake PA. Salmonella typhi infections in the

United States, 1975-1984: increasing role of foreign travel. Rev Infect Dis 1989;II:1-7. Woodruff BA, Pavia AT, Blake PA. A new look at typhoid vaccination: informa-

tion for the practicing physician. JAMA 1991;265(6):756-9.

Varicella

CDC. Varicella outbreak in a women's prison -- Kentucky. MMWR 1989;38(37):

635-6,641-2. Gershon AA, LaRussa P, Hardy I, Steinberg S, Silverstein S. Varicella vac-

cine: the American experience. J Infect Dis 1992;166(suppl 1):S63-8. Lieu TA, Cochi SL, Black SB, et al. Cost-effectiveness of a routine varicella

vaccination program for U.S. children. JAMA 1994;271:375-81.


PART 1: Summaries of Notifiable Diseases in the United States

Table_N1 NOTIFIABLE DISEASES -- summary of reported cases, by month,

United States, 1993

Table_N2 NOTIFIABLE DISEASES -- reported cases, by geographic division

and area, United States, 1993

Table_N3 NOTIFIABLE DISEASES -- summary of reported cases, by age

group, United States, 1993

Table_N4 NOTIFIABLE DISEASES -- summary of reported cases, by race,

United States, 1993

Table_N5 NOTIFIABLE DISEASES -- summary of reported cases, by ethnici-

ty, United States, 1993


PART 2: Graphs and Maps for Selected Notifiable Diseases in the United States

Figure_1 ACQUIRED IMMUNODEFICIENCY SYNDROME (AIDS) -- reported cases

and known deaths, by year, United States, 1981-1993

Figure_2 ACQUIRED IMMUNODEFICIENCY SYNDROME (AIDS) -- annual rates, by

selected age group and sex for reported cases, United States, 1993

Figure_3 ACQUIRED IMMUNODEFICIENCY SYNDROME (AIDS) -- reported pediat-

ric cases, United States and Puerto Rico, 1993

Figure_4 ACQUIRED IMMUNODEFICIENCY SYNDROME (AIDS) -- reported cases,

per 100,000 population, United States and Puerto Rico, 1993

Figure_5 ACQUIRED IMMUNODEFICIENCY SYNDROME (AIDS) -- reported adult/

adolescent cases among men, by exposure category, United States, 1993

Figure_6 ACQUIRED IMMUNODEFICIENCY SYNDROME (AIDS) -- reported adult/

adolescent cases among women, by exposure category, United States, 1993

Figure_7 ARBOVIRAL INFECTIONS (of the central nervous system) -- cases

due to St. Louis encephalitis virus, by month, United States, 1975-1993

Figure_8 ARBOVIRAL INFECTIONS (of the central nervous system) -- cases

due to California serogroup viruses, by month, United States, 1975-1993

Figure_9 ARBOVIRAL INFECTIONS (of the central nervous system) --

cases due to Western equine encephalitis virus, by month, United States, 1975-1993

Figure_10 ARBOVIRAL INFECTIONS (of the central nervous system) --

cases due to Eastern equine encephalitis virus, by month, United States, 1975-1993

Figure_11 ASEPTIC MENINGITIS -- by month, United States, 1986-1993 Year

Figure_12 AMEBIASIS -- by year, United States, 1955-1993

Figure_13 ASEPTIC MENINGITIS -- reported cases, per 100,000 population,

United States and territories, 1993

Figure_14 BOTULISM (infant) -- by year, United States, 1975-1993

Figure_15 BOTULISM (foodborne) -- by year, United States, 1975-1993

Figure_16 BRUCELLOSIS -- by year, United States, 1945-1993

Figure_17 CHOLERA -- reported cases, United States and territories,

1993

Figure_18 DIPHTHERIA -- by year, United States, 1955-1993

Figure_19 ENCEPHALITIS (post-infectious) -- by year, United States,

1984-1993

Figure_20 GONORRHEA -- by sex, United States, 1960-1993

Figure_21 GONORRHEA -- by race and ethnicity, United States, 1981-1993

Figure_22 GONORRHEA -- reported cases, per 100,000 population, United

States, 1993

Figure_23 HAEMOPHILUS INFLUENZAE -- reported cases, per 100,000 popula-

tion, United States and territories, 1993

Figure_24 HAEMOPHILUS INFLUENZAE -- by age group, United States, 1993

Figure_25 HANSEN DISEASE (leprosy) -- by year, United States, 1955-1993

Figure_26 HEPATITIS -- by year, United States, 1965-1993

Figure_27 HEPATITIS A -- reported cases, per 100,000 population, United

States and territories, 1993

Figure_28 HEPATITIS B -- reported cases, per 100,000 population, United

States and territories, 1993

Figure_29 LEGIONELLOSIS -- reported cases, per 100,000 population,

United States and territories, 1993

Figure_30 LEPTOSPIROSIS -- by year, United States, 1955-1993

Figure_31 LYME DISEASE -- reported cases, per 100,000 population,

United States and territories, 1993

Figure_32 MALARIA -- by year, United States, 1930-1993

Figure_33 MEASLES (rubeola) -- by year, United States, 1950-1993

Figure_34 MEASLES (rubeola) -- counties reporting cases, United States,

1993

Figure_35 MENINGOCOCCAL INFECTION -- counties reporting cases, United

States, 1993

Figure_36 MENINGOCOCCAL INFECTION -- by year, United States, 1935-1993

Figure_37 MUMPS -- by year, United States, 1968-1993

Figure_38 MURINE TYPHUS FEVER -- by year, United States, 1955-1993

Figure_39 PERTUSSIS (whooping cough) -- by year, United States, 1957-

1993

Figure_40 PERTUSSIS (whooping cough) -- by age group, United States,

1993

Figure_41 PERTUSSIS (whooping cough) -- reported cases, per 100,000

population, United States and territories, 1993

Figure_42 PLAGUE -- among humans, by year, United States, 1955-1993

Figure_43 POLIOMYELITIS (paralytic) -- by year, United States, 1951-

1993

Figure_44 PSITTACOSIS -- by year, United States, 1955-1993

Figure_45 RABIES -- wild and domestic animals, by year, United States

and Puerto Rico, 1955-1993

Figure_46 RHEUMATIC FEVER -- reported cases, United States and territo-

ries, 1993

Figure_47 ROCKY MOUNTAIN SPOTTED FEVER -- counties reporting cases,

United States, 1993

Figure_48 ROCKY MOUNTAIN SPOTTED FEVER -- by year, United States,

1955-1993

Figure_49 RUBELLA (German measles) -- by year, United States, 1966-1993

Figure_50 SALMONELLOSIS (excluding typhoid fever) -- by year, United

States, 1955-1993

Figure_51 SHIGELLOSIS -- by year, United States, 1955-1993

Figure_52 SYPHILIS -- by year, United States, 1941-1993

Figure_53 SYPHILIS (primary and secondary) -- reported cases, per

100,000 population, United States, 1993

Figure_54 SYPHILIS (primary and secondary) -- counties with rates above

and below the Year 2000 Objective, United States, 1993

Figure_55 SYPHILIS (primary and secondary) -- by race and ethnicity,

United States, 1981-1993

Figure_56 SYPHILIS (primary and secondary) -- by sex, United States,

1956-1993

Figure_57 CONGENITAL SYPHILIS -- reported cases in infants <1 year of

age and rate of primary and secondary syphilis among women -- United States, 1970-1993

Figure_58 TETANUS -- by year, United States, 1955-1993

Figure_59 TETANUS -- by age group, United States, 1993

Figure_60 TOXIC SHOCK SYNDROME -- by quarter, United States, 1979-1993

Figure_61 TRICHINOSIS -- by year, United States, 1950-1993

Figure_62 TUBERCULOSIS -- rates by state, United States, 1993

Figure_63 TUBERCULOSIS -- percentage of cases, by race and ethnicity,

United States, 1993

Figure_64 TUBERCULOSIS - by year, United States, 1975-1993

Figure_65 TUBERCULOSIS -- frequency distribution of cases by age, race,

and ethnicity, United States, 1993

Figure_66 TUBERCULOSIS -- cases, among foreign-born persons and persons

born in the United Sates, 1993

Figure_67 TULAREMIA -- by year, United States, 1955-1993

Figure_68 TULAREMIA -- counties reporting cases, United States, 1993

Figure_69 TYPHOID FEVER -- by year, United States, 1955-1993

Figure_70 VARICELLA (chickenpox) -- by month, United States, 1986-1993


PART 3: Historical Summary Tables

TABLE_1 NOTIFIABLE DISEASES -- summary of reported cases, United

States, 1984-1993

TABLE_2 NOTIFIABLE DISEASES -- summary of reported cases, per 100,000

population, United States, 1984-1993

TABLE_3 NOTIFIABLE DISEASES -- summary of reported cases, United

States, 1974-1983

TABLE_4 NOTIFIABLE DISEASES -- summary of reported cases, United

States, 1964-1973

TABLE_5 NOTIFIABLE DISEASES -- summary of reported cases, United

States, 1954-1963

TABLE_6 NOTIFIABLE DISEASES -- summary of reported cases, United

States, 1944-1953

TABLE_7 NOTIFIABLE DISEASES -- deaths from specified notifiable

diseases, United States, 1982-1991
Table_N1
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NOTIFIABLE DISEASES -- summary of reported cases, by month, United States, 1993
===========================================================================================================================================================================================
Disease                               Total      Jan.      Feb.      Mar.      Apr.      May       June      July      Aug.      Sept.     Oct.      Nov.      Dec.        Unk.
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
AIDS *                               103,691     7,153     7,222    21,244     6,725    10,081     8,254     7,597     8,524     9,176     5,072     5,797     6,846         -
Amebiasis                              2,970       144       198       202       211       218       228       284       313       272       310       245       345         -
Anthrax                                    -         -         -         -         -         -         -         -         -         -         -         -         -         -
Aseptic meningitis                    12,848       519       532       502       478       698       739     1,569     1,891     1,797     1,909     1,005     1,209         -
Botulism, total                           97         6         5         4         5         6         6        11        11         8        16        10         9         -
Brucellosis                              120         4         6         6         7         8         6        12         8         3        11         7        42         -
Chancroid +                            1,399   ..............401..........   ..............469..........   ..............229..........   ..............300..........         -
Cholera                                   18         5         3         1         3         2         -         2         -         1         1         -         -         -
Diphtheria                                 -         -         -         -         -         -         -         -         -         -         -         -         -         -
Encephalitis, primary infections         919        43        49        45        33        53        45        84        93       158       152        72        92         -
  Post-infectious                        170         7        20        16        14        17        17        13        15         9        10        14        18         -
Gonorrhea +                          439,673   ..........103,178..........   ..........102,890..........   ..........120,498..........   ..........113,107..........         -
Granuloma inguinale +                     19   ...............15..........   ................4..........   ................-..........   ................-..........         -
Haemophilus influenzae                 1,419        99       104       149        97       141       100       105        68        78       126       155       197         -
Hansen disease (leprosy)                 187        11         9        20        17        27        10         8        18        14        30        11        12         -
Hepatitis A                           24,238     1,739     1,718     1,985     1,739     2,104     1,678     2,132     1,661     1,838     2,535     1,916     3,193         -
Hepatitis B                           13,361       772       918     1,000     1,038     1,311       999     1,191       994     1,003     1,207     1,036     1,892         -
Hepatitis, non-A , non-B &             4,786       272       354       337       293       383       301       347       340       364       496       384       915         -
Hepatitis, unspecified                   627        44        47        52        43        77        34        61        40        55        49        39        86         -
Legionellosis                          1,280       110        81        88        77       112        86       104       107       104       155        88       168         -
Leptospirosis                             51         1         8         1         1         3         2         4         7         5         3         8         8         -
Lyme disease                           8,257       175       310       323       234       433       524     1,474     1,156       845       840       738     1,205         -
Lymphogranuloma venereum +               285   ...............69..........   ...............73..........   ...............71 .........   ...............72..........         -
Malaria                                1,411        51        69        74       118        77        98       144       154       124       200       110       192         -
Measles (rubeola)                        312        17        41        27        11        28        72        28        24        17        26         9        12         -
Meningococcal infections               2,637       155       211       311       251       273       180       204       109       121       202       160       460         -
Mumps                                  1,692       101       132       169       144       186       191       120        80        97       138       126       208         -
Murine typhus fever                       25         -         -         1         -         3         -         5         -         4         4         4         4         -
Pertussis (whooping cough)             6,586       214       236       202       239       298       329       777       876       988     1,061       469       897         -
Plague                                    10         -         -         1         -         2         -         1         4         -         2         -         -         -
Poliomyelitis, paralytic @                 3         -         -         -         -         -         -         1         1         -         -         -         1
Psittacosis                               60         3         7         4         3         8         6         5         7         4         1         7         5         -
Rabies, animal                         9,377       408       512       649       801       994       724       876       930       899     1,001       713       870         -
Rabies, human                              3         -         -         -         -         -         -         -         1         -         -         -         2         -
Rheumatic fever, acute                   112         5        16        12         4        10        28        13         7         1         3         4         9         -
Rocky Mountain spotted fever             456         9         3         3         3        16        38        90        95        69        74        24        32         -
Rubella (German measles)                 192        10         8        25        15        30        20        30        19         7         5         6        17         -
Rubella, congenital syndrome               5         1         1         -         2         -         -         1         -         -         -         -         -         -
Salmonellosis                         41,641     1,909     2,099     2,196     2,188     3,131     3,256     4,819     5,119     4,367     4,980     3,164     4,413         -
Shigellosis                           32,198     1,224     1,554     1,507     1,572     2,511     2,799     3,494     3,665     3,060     4,005     2,725     4,082         -
Syphilis, total all stages +         101,259   ...........25,621..........   ...........26,942..........   ...........24,692..........   ...........24,004..........         -
  Primary and secondary +             26,498   ............6,952..........   ............6,684..........   ............6,621..........   ............6,241..........         -
  Congenital <1 year +                 3,211   ..............678..........   ..............834..........   ..............864..........   ..............835..........         -
Tetanus                                   48         1         1         1         3         5         5         4         7         5         4         3         9         -
Toxic-shock syndrome                     212         7        21        26        23        16        15        19        25        23        15         6        16         -
Trichinosis                               16         1         3         3         -         -         1         -         2         -         2         1         3         -
Tuberculosis                          25,313       778     1,322     1,881     2,105     1,979     2,371     2,003     2,009     1,938     2,028     1,769     5,130         -
Tularemia                                132         3         5         4         3        13        20        24        21        12        12         2        13         -
Typhoid fever                            440        26        24        26        25        40        26        46        38        46        62        30        51         -
Varicella (chickenpox)               134,722    12,815    15,322    18,553    17,373    23,933    13,866     5,129     3,093     2,534     4,038     6,536    11,530
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
* AIDS total updated through December 31, 1993.                     & The number of reported cases of non-A, non-B hepatitis is misleading because in some states, reported cases
+ Cases updated through Feburary 28, 1994.                            included persons positive for antibody to hepatitis C virus (anti-HCV) identified in routine screening programs but
                                                                      who did not have acute hepatitis.
                                                                    @ Subject to change due to retrospective case evaluations or late reports.
===========================================================================================================================================================================================

Return to top.

Table_N2
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NOTIFIABLE DISEASES -- reported cases, by geographic division and area, United States,
1993 (Page 1)
----------------------------------------------------------------------------------------------------------------------
                    Total resident                                                         Botulism
                      population                                      Aseptic     --------------------------   Brucel-
Area                (in thousands)     AIDS    Amebiasis   Anthrax   meningitis   Foodborne   Infant   Other    losis
----------------------------------------------------------------------------------------------------------------------
United States          257,908       103,691 *   2,970        -        12,848         27        65       5 +     120
New England             13,230         5,156       112        -           425          -         -       -         1
  Maine                  1,239           149        11        -            41          -         -       -         -
  N.H.                   1,125           124         5        -            55          -         -       -         -
  Vt.                      576            74         7        -            45          -         -       -         -
  Mass.                  6,012         2,703        87        -           177          -         -       -         1
  R.I.                   1,000           348         2        -           107          -         -       -         -
  Conn.                  3,277         1,758        NN        -            NN          -         -       -         -
Mid. Atlantic           38,125        26,115       619        -         1,133          -         8       1         3
  N.Y. (excl. NYC)      10,921         3,565       116        -           575          -         -       -         1
  N.Y.C.                 7,276        13,902       457        -           257          -         2       1         -
  N.J.                   7,879         5,434        16        -            NN          -         3       -         1
  Pa.                   12,048         3,214        30        -           301          -         3       -         1
E.N. Central            43,017         8,069       208        -         2,234          -         6       1        10
  Ohio                  11,091         1,585        18        -           720          -         5       1         1
  Ind.                   5,713           954        25        -           244          -         1       -         -
  Ill.                  11,697         2,959        50        -           562          -         -       -         6
  Mich.                  9,478         1,840        48        -           643          -         -       -         1
  Wis.                   5,038           731        67        -            65          -         -       -         2
W.N. Central            18,054         3,181       173        -           817          -         -       -         3
  Minn.                  4,517           659        58        -           118          -         -       -         -
  Iowa                   2,814           202        31        -           159          -         -       -         2
  Mo.                    5,234         1,745        54        -           275          -         -       -         -
  N. Dak.                  635            11         3        -            20          -         -       -         -
  S. Dak.                  715            29         1        -            22          -         -       -         1
  Nebr.                  1,607           179         4        -            21          -         -       -         -
  Kans.                  2,531           356        22        -           202          -         -       -         -
S. Atlantic             45,738        22,783       198        -         2,645          6         2       -        36
  Del.                     700           375         2        -            70          -         1       -         -
  Md.                    4,965         2,528         9        -           220          -         -       -         -
  D.C.                     578         1,585         -        -            37          -         -       -         -
  Va.                    6,491         1,625        34        -           343          -         -       -         -
  W. Va.                 1,820           106         2        -            56          -         -       -         -
  N.C.                   6,945         1,368        11        -           273          -         -       -        27
  S.C.                   3,643         1,476        NN        -            35          -         -       -         -
  Ga.                    6,917         2,789        90        -           173          5         1       -         5
  Fla.                  13,679        10,931        50        -         1,438          1         -       -         4
E.S. Central            15,717         2,720         7        -           774          2         4       -         1
  Ky.                    3,789           323         1        -           335          1         1       -         -
  Tenn.                  5,099         1,203        NN        -           166          1         -       -         -
  Ala.                   4,187           733         1        -           192          -         -       -         1
  Miss.                  2,643           461         5        -            81          -         3       -         -
W.S. Central            27,983        10,136       102        -         1,500          -         3       -        40
  Ark.                   2,424           404         4        -            79          -         1       -         3
  La.                    4,295         1,464         5        -            91          -         -       -         2
  Okla.                  3,231           725         7        -             1          -         -       -         1
  Tex.                  18,031         7,543        86        -         1,329          -         2       -        34
Mountain                14,776         3,913       177        -           732          3         4       -         6
  Mont.                    839            32         -        -             1          -         -       -         -
  Idaho                  1,099            77         7        -            11          -         2       -         -
  Wyo.                     470            46         3        -             8          1         -       -         -
  Colo.                  3,566         1,324        66        -           240          1         -       -         3
  N. Mex.                1,616           294        21        -           115          -         -       -         1
  Ariz.                  3,936         1,238        70        -           202          -         1       -         2
  Utah                   1,860           264         4        -            74          1         1       -         -
  Nev.                   1,389           638         6        -            81          -         -       -         -
Pacific                 41,269        21,460     1,374        -         2,588         16        38       3        20
  Wash.                  5,255         1,564        49        -            NN          4         5       -         -
  Oreg.                  3,032           778        95        -            NN          -         2       -         -
  Calif.                31,211        18,689     1,193        -         2,428          3        29       3        19
  Alaska                   599            70         6        -            23          9         -       -         -
  Hawaii                 1,172           359        31        -           137          -         2       -         1
----------------------------------------------------------------------------------------------------------------------
  Guam                     133             2         -        -             7          -         -       -         -
  P.R.                   3,522         3,199         -        -            72          -         -       -         -
  V.I.                     102            57         -        -             -          -         -       -         -
  C.N.M.I.                  43             -         -        -             2          -         -       -         -
  American Samoa            47             -         -        -             -          -         -       -         -
----------------------------------------------------------------------------------------------------------------------
* Total reported through December 31, 1993. Total includes 158 cases with unknown state of residence.
+ Includes wound and unspecified botulism.

====================================================================================================================================

NOTIFIABLE DISEASES -- reported cases, by geographic division and area, United States,
1993 (Page 2)
---------------------------------------------------------------------------------------------------------------------------------
                                                              Encephalitis
                                                         -----------------------                                         Hansen
                                                          Primary        Post-      Gonor-    Granuloma   Haemophilus    disease
Area                  Chancroid   Cholera   Diphtheria   infections   infectious     rhea     inguinale   influenzae    (leprosy)
---------------------------------------------------------------------------------------------------------------------------------
UNITED STATES            1,399 *     18         -            919          170       439,673 *     19 *       1,419         187
New England                  5        2         -             26            8         8,391        -            59           7
  Maine                      -        -         -              3            -            80        -             4           -
  N.H.                       3        -         -              -            2            83        -             6           -
  Vt.                        -        -         -              6            -            25        -             3           -
  Mass.                      2        -         -             12            4         3,118        -            35           7
  R.I.                       -        1         -              5            2           427        -             2           -
  Conn.                      -        1         -              -            -         4,658        -             9           -
Mid. Atlantic              618        -         -             63           11        54,796        -           135          18
  N.Y. (excl. NYC)           5        -         -             45            6        10,887        -            43           1
  N.Y.C.                   613        -         -              3            -        19,240        -            34          14
  N.J.                       -        -         -              -            -         6,444        -            27           3
  Pa.                        -        -         -             15            5        18,225        -            31           -
E.N. Central               115        3         -            226           22        80,638        1           221           4
  Ohio                      21        1         -             72            4        22,286        1           125           1
  Ind.                       3        -         -             20            5         8,656        -            12           -
  Ill.                      91        2         -             62            3        28,412        -            57           2
  Mich.                      -        -         -             54           10        18,014        -            18           -
  Wis.                       -        -         -             18            -         3,270        -             9           1
W.N. Central                 3        -         -             56           17        22,415        1           180           1
  Minn.                      1        -         -             18            -         2,543        -            21           -
  Iowa                       -        -         -              7            2         1,915        1             8           -
  Mo.                        1        -         -             11           15        13,148        -           135           -
  N. Dak.                    -        -         -              5            -            54        -             -           -
  S. Dak.                    -        -         -              7            -           270        -             2           -
  Nebr.                      -        -         -              1            -           714        -             9           1
  Kans.                      1        -         -              7            -         3,771        -             5           -
S. Atlantic                 86        2         -            231           78       124,475       13           244          13
  Del.                       1        -         -              3            -         1,586        -             -           -
  Md.                        -        -         -             25            -        13,548        -            52           1
  D.C.                       1        -         -              -            1         6,162        -             1           -
  Va.                        3        1         -             44            7        12,022        -            28           -
  W. Va.                     1        -         -            117            -           635        -            10           -
  N.C.                      13        -         -             31            -        24,187        1            23           1
  S.C.                       -        -         -              -            -        10,953        -            40           -
  Ga.                       21        -         -              2            -        31,483       12            71           -
  Fla.                      46        1         -              9           70        23,899        -            19          11
E.S. Central                35        -         -             37            7        45,173        -            56           2
  Ky.                        4        -         -             21            6         4,627        -            16           -
  Tenn.                      8        -         -             10            -        14,285        -            12           -
  Ala.                      23        -         -              3            -        15,793        -            18           2
  Miss.                      -        -         -              3            1        10,468        -            10           -
W.S. CENTRAL               517        2         -             80            2        55,795        1           109          33
  Ark.                     170        -         -              3            -         7,590        -             8           -
  La.                      310        -         -             10            -        13,323        1             4           -
  Okla.                      -        -         -              8            -         4,759        -            46           2
  Tex.                      37        2         -             59            2        30,123        -            51          31
Mountain                     8        3         -             21            5        11,549        1           125           6
  Mont.                      -        -         -              -            1            81        -             5           -
  Idaho                      -        -         -              -            -           171        -             3           1
  Wyo.                       1        -         -              -            -            85        -             5           -
  Colo.                      -        1         -             14            -         3,803        -            24           -
  N. Mex.                    -        -         -              4            2         1,014        -             9           -
  Ariz.                      3        -         -              -            -         4,176        1            31           3
  Utah                       4        2         -              1            1           350        -            12           1
  Nev.                       -        -         -              2            1         1,869        -            36           1
PACIFIC                     12        6         -            179           20        36,441        2           290         103
  Wash.                      -        -         -              1            -         3,740        -            19           9
  Oreg.                      -        -         -              -            -         1,189        -            11           -
  Calif.                    12        6         -            167           20        29,970        2           240          75
  Alaska                     -        -         -             10            -           678        -             6           1
  Hawaii                     -        -         -              1            -           864        -            14          18
---------------------------------------------------------------------------------------------------------------------------------
  Guam                       -        -         -              -            -            83        -             -           4
  P.R.                      25        -         -              -            -           527        1             3           -
  V.I.                       5        -         -              -            -            84        -             -           -
  C.N.M.I.                   -        -         -              1            -             -        -            24           2
  American Samoa             -        -         -              -            -             -        -             -           -
---------------------------------------------------------------------------------------------------------------------------------
* Cases updated through February 28, 1994.

====================================================================================================================================

NOTIFIABLE DISEASES -- reported cases, by geographic division and area, United States,
1993 (Page 3)
-------------------------------------------------------------------------------------------------------------------------------
                                                   Hepatitis                                                 Lympho-
                                                     non-A,    Hepatitis   Legionel-    Lepto-     Lyme     granuloma
Area                   Hepatitis A   Hepatitis B     non-B       unsp.      losis      spirosis   disease   venereum    Malaria
-------------------------------------------------------------------------------------------------------------------------------
United States             24,238        13,361       4,786 *      627       1,280         51       8,257       285 +     1,411
New England                  448           356         106         13          66          -       1,815         8          97
  Maine                       14            11           2          -           6          -          18         -           7
  N.H.                        18            27           8          -           2          -          15         1           4
  Vt.                          9            10           6          -           3          -          12         -           3
  Mass.                      213           214          77         13          32          -         148         7          46
  R.I.                        77            19          13          -          23          -         272         -           7
  Conn.                      117            75           -          -          NN          -       1,350         -          30
Mid. Atlantic              1,665         1,574         398          7         253          3       4,689       184         325
  N.Y. (excl. NYC)           464           457         259          1          89          2       2,758        12         123
  N.Y.C.                     722           353           3          -           3          -          60       172         126
  N.J.                       295           407          98          -          33          1         786         -          51
  Pa.                        184           357          38          6         128          -       1,085         -          25
E.N. Central               2,727         1,497         595         15         327          5         505         4          93
  Ohio                       338           192          37          -         154          2          30         4          15
  Ind.                       646           249          15          1          49          -          32         -           2
  Ill.                     1,023           344         102          7          26          3          19         -          46
  Mich.                      213           393         400          7          62          -          23         -          19
  Wis.                       507           319          41          -          36          -         401         -          11
W.N. Central               2,372           802          79         27          95          8         319         2          45
  Minn.                      497            96          14          4           3          -         141         -          21
  Iowa                        60            36           9          4          19          3           8         -           5
  Mo.                      1,443           585          25         19          33          3         108         1           9
  N. Dak.                     80             1           3          -           2          -           2         -           1
  S. Dak.                     18             -           -          -           -          -           -         1           2
  Nebr.                      195            19          11          -          30          2           6         -           4
  Kans.                       79            65          17          -           8          -          54         -           3
S. Atlantic                1,329         2,408         723         95         219          2         639        60         338
  Del.                        12            18           1          -           4          1         143         -           2
  Md.                        159           265          42          3          56          -         180         2          48
  D.C.                        11            43           3          -          15          -           2         8          11
  Va.                        156           157          54         43          11          -          95         7          41
  W. Va.                      29            44          43          -           4          -          50         -           2
  N.C.                        94           315          80          -          27          1          86        16         145
  S.C.                        18            51           5          1          19          -           9         -           7
  Ga.                        145           670         451          1          36          -          44        22          20
  Fla.                       705           845          44         47          47          -          30         5          62
E.S. Central                 364         1,748       1,025          4          44          2          40         3          29
  Ky.                        142            99          16          -          19          -          16         1           5
  Tenn.                      104         1,152         994          3          17          1          20         1          12
  Ala.                        58           107           5          1           2          1           4         1           7
  Miss.                       60           390          10          -           6          -           -         -           5
W.S. Central               3,190         1,909         645        173          51          6          78        14          65
  Ark.                        74            90           5          3           6          1           8         -           4
  La.                        105           269         178          4          10          5           3        12           7
  Okla.                      213           195          50          9          13          -          19         -           6
  Tex.                     2,798         1,355         412        157          22          -          48         2          48
Mountain                   4,164           686         366         79          81          -          20         1          40
  Mont.                       77            28           3          -           7          -           -         -           2
  Idaho                      298            89           -          3           1          -           2         -           1
  Wyo.                        17            34         119          -           7          -           9         -           -
  Colo.                      877            81          62         44           9          -           -         -          25
  N. Mex.                    400           215         107          3           6          -           2         -           5
  Ariz.                    1,493            96          13         14          17          -           -         1           1
  Utah                       828            69          42         13          16          -           2         -           2
  Nev.                       174            74          20          2          18          -           5         -           4
Pacific                    7,979         2,381         849        214         144         25         152         9         379
  Wash.                      926           247         219         11          12          -           9         4          41
  Oreg.                      532           221          55          2           1          1           8 &       1          14
  Calif.                   5,677         1,876         560        198         121          -         134         4         314
  Alaska                     775            15          12          -           -          -           -         -           3
  Hawaii                      69            22           3          3          10         24           1         -           7
-------------------------------------------------------------------------------------------------------------------------------
  Guam                         3             6           -         11           -          -           -         -            3
  P.R.                        79           412          90          2           -         11           -         1            -
  V.I.                         1             6           -          -           -          -           -         -            -
  C.N.M.I.                     -             2           -          1           -          1           -         -            2
  American Samoa              20             1           -          -           -          -           -         -            -
-------------------------------------------------------------------------------------------------------------------------------
* The number of reported cases of non-A, non-B hepatitis is misleading because in some states, reported cases included persons
  positive for antibody to hepatitis C virus (anti-HCV) identified in routine screening programs but who did not have hepatitis.
+ Cases updated through February 28, 1994.
& Voluntarily reportable for this state.

====================================================================================================================================

NOTIFIABLE DISEASES -- reported cases, by geographic division and area, United States,
1993 (Page 4)
-----------------------------------------------------------------------------------------------------------
                              Measles           Meningo-            Murine                         Polio-
                       ---------------------     coccal             typhus                        myelitis,
Area                   Indigenous   Imported   infections   Mumps   fever    Pertussis   Plague   paralytic
-----------------------------------------------------------------------------------------------------------
United States             237          75 *      2,637      1,692     25       6,586       10         3 +
New England                54           9          133         15      -         834        -         -
  Maine                     1           -           15          -      -          20        -         -
  N.H.                      2           -            6          3      -         168        -         -
  Vt.                      30           1            7          1      -         122        -         -
  Mass.                    11           7           72          1      -         408        -         -
  R.I.                      1           1            -          2      -          14        -         -
  Conn.                     9           -           33          8      -         102        -         -
Mid. Atlantic              22          19          310        135      2         991        -         1
  N.Y. (excl. NYC)          4           7          126         46      1         373        -         -
  N.Y.C.                   12           7           37          2      1         116        -         1
  N.J.                      6           5           50         17      -          85        -         -
  Pa.                       -           -           97         70      -         417        -         -
E.N. Central               20          11          375        259      -       1,627        -         -
  Ohio                      6           3          108         74      -         523        -         -
  Ind.                      1           -           51          8      -         178        -         -
  Ill.                      5           4          104         74      -         434        -         -
  Mich.                     5           1           65         80      -         116        -         -
  Wis.                      3           3           47         23      -         376        -         -
W.N. Central                1           2          142         67      -         626        -         -
  Minn.                     -           -           23          2      -         393        -         -
  Iowa                      -           -           28         11      -          38        -         -
  Mo.                       1           -           34         46      -         144        -         -
  N. Dak.                   -           -            3          6      -           5        -         -
  S.  Dak.                  -           -            7          -      -           8        -         -
  Nebr.                     -           -           11          1      -          14        -         -
  Kans.                     -           2           36          1      -          24        -         -
S. Atlantic                25           8          470        463      1         673        -         1
  Del.                      -           -           15          1      -          11        -         -
  Md.                       -           4           60         82      -         133        -         1
  D.C.                      -           -            6          1      -          14        -         -
  Va.                       -           4           52         40      1          75        -         -
  W. Va.                    -           -           19         23      -           8        -         -
  N.C.                      1           -           67        231      -         199        -         -
  S.C.                      -           -           31         17      -          73        -         -
  Ga.                       -           -           94         20      -          56        -         -
  Fla.                     24           -          126         48      -         104        -         -
E.S. Central                1           -          154         58      1         297        -         -
  Ky.                       -           -           25          -      -          38        -         -
  Tenn.                     -           -           45         19      1         183        -         -
  Ala.                      1           -           53         22      -          65        -         -
  Miss.                     -           -           31         17      -          11        -         -
W.S. Central                8           3          264        274     13         239        1         -
  Ark.                      -           -           27         10      1          18        -         -
  La.                       1           -           46         20      -          14        -         -
  Okla.                     -           -           34         13      -          86        -         -
  Tex.                      7           3          157        231     12         121        1         -
Mountain                    4           3          211         81      -         464       10         -
  Mont.                     -           -           13          -      -          11        -         -
  Idaho                     -           -           21          6      -         101        -         -
  Wyo.                      -           -            5          5      -           2        -         -
  Colo.                     3           -           41         18      -         187        2         -
  N. Mex.                   -           -            8         NN      -          43        6         -
  Ariz.                     -           3           86         19      -          70        -         -
  Utah                      -           -           24          6      -          45        1         -
  Nev.                      1           -           13         27      -           5        -         -
Pacific                   102          20          578        340      8         835        -         1
  Wash.                     -           -           97         14      -          91        -         1
  Oreg.                     -           4          110         NN      -         106        -         -
  Calif.                   89           7          346        285      8         619        -         -
  Alaska                    2           -           15         11      -           5        -         -
  Hawaii                   11           9           10         30      -          14        -         -
-----------------------------------------------------------------------------------------------------------
  Guam                     22           3            1         13      -           -        -         -
  P.R.                    356           -           14          3      -          11        -         -
  V.I.                      -           -            -          5      -           -        -         -
  C.N.M.I.                 92           1            -         15      -           1        -         -
  American Samoa            -           -            -          5      -           2        -         -
-----------------------------------------------------------------------------------------------------------
* For measles only, imported includes both out-of-state and international importations.
+ Ten suspected cases of paralytic poliomyelitis were reported in 1993. Three cases have been confirmed as of August 12, 1994,
  two of which were vaccine-associated; one was classified as imported. The number of reported cases is subject to change due
  to retrospective case evaluations or late reports.

====================================================================================================================================

NOTIFIABLE DISEASES -- reported cases, by geographic division and area, United States,
1993 (Page 5)
----------------------------------------------------------------------------------------------------------------
                                                                             Rubella
                                     Rabies        Rheumatic            ------------------
                       Psitta-   ---------------    fever,                         Cong.     Salmonel-   Shigel-
Area                   cosis     Animal    Human     acute     RMSF *   Rubella   syndrome     losis      losis
----------------------------------------------------------------------------------------------------------------
United States            60      9,377       3        112      456        192        5        41,641     32,198
New England               2      1,695       -          2        4         10        -         3,882        605
  Maine                   -          -       -          1        -          1        -           158          8
  N.H.                    -        148       -         NN        -          -        -           220         17
  Vt.                     1         45       -          -        -          -        -           421          8
  Mass.                   1        720       -          -        4          9        -         2,041        285
  R.I.                    -          2       -          -        -          -        -           231         42
  Conn.                   -        780       -          1        -          -        -           811        245
Mid. Atlantic            16      3,585       1          -       28         59        2         7,005      2,218
  N.Y. (excl. NYC)        5      2,692       1         NN        7         17        1         2,390        790
  N.Y.C.                  -         53       -         NN        1         22        -         1,601        554
  N.J.                    2        458       -          -       10         15        -         1,215        347
  Pa.                     9        382       -         NN       10          5        1         1,799        527
E.N. Central              8        110       -         33       18          8        -         5,810      5,111
  Ohio                    4          6       -          5        8          1        -         1,214      1,411
  Ind.                    -         12       -          -        4          3        -           543        811
  Ill.                    1         23       -          2        4          1        -         2,232      1,722
  Mich.                   1         18       -         21        2          2        -           815        829
  Wis.                    2         51       -          5        -          1        -         1,006        338
W.N. Central              3        351       -         26       34          1        -         1,924      1,509
  Minn.                   -         45       -          7        1          -        -           551        240
  Iowa                    2         79       -          2        7          -        -           241         69
  Mo.                     1         35       -          -       20          1        -           529        674
  N. Dak.                 -         57       -         NN        -          -        -            60          7
  S. Dak.                 -         49       -         14        3          -        -            99        111
  Nebr.                   -          7       -         NN        2          -        -           145        200
  Kans.                   -         79       -          3        1          -        -           299        208
S. Atlantic               8      2,165       -          -      215          7        -         8,502      7,049
  Del.                    -        135       -         NN        -          -        -           185        178
  Md.                     2        605       -         NN       14          3        -           936        384
  D.C.                    -         18       -         NN        -          -        -           102         87
  Va.                     1        387       -         NN       14          -        -         1,055        776
  W. Va.                  -         90       -          -        6          -        -           109         38
  N.C.                    4        107       -         NN      129          -        -         1,121      2,305
  S.C.                    1        165       -         NN       11          -        -           738        414
  Ga.                     -        471       -         NN       37          -        -         1,316        474
  Fla.                    -        187       -         NN        4          4        -         2,940      2,393
E.S. Central              1        260       -          -       63          1        -         1,879      1,849
  Ky.                     -         20       -         NN       16          1        -           302        171
  Tenn.                   1        124       -         NN       32          -        -           558        938
  Ala.                    -        116       -         NN        4          -        -           554        375
  Miss.                   -          -       -         -        11          -        -           465        365
W.S. Central              2        635       1         -        77         24        -         3,297      5,748
  Ark.                    -         42       -         -        17          -        -           402        201
  La.                     -         17       -        NN         2          1        -           650        482
  Okla.                   1         65       -        NN        51          1        -           321        484
  Tex.                    1        511       1        NN         7         22        -         1,924      4,581
Mountain                  3        178       -        28        16         12        -         2,018      1,921
  Mont.                   -         24       -        NN         2          -        -           106         56
  Idaho                   1          8       -        NN         -          2        -           173         46
  Wyo.                    -         25       -         1        10          -        -            59         22
  Colo.                   -         29       -         5         4          3        -           550        611
  N. Mex.                 1          9       -         3         -          -        -           326        411
  Ariz.                   -         60       -        NN         -          2        -           519        693
  Utah                    1          8       -        19         -          4        -           154         42
  Nev.                    -         15       -        NN         -          1        -           131         40
Pacific                  17        398       1        23         1         70        3         7,324      6,188
  Wash.                   4          -       -         -         -          -        -           832        797
  Oreg.                   4          7       -        NN         1          -        -           349        169
  Calif.                  9        363       1        20         -         41        3         5,739      5,093
  Alaska                  -         28       -         3         -          1        -            59         30
  Hawaii                  -          -       -        NN         -         28        -           345         99
----------------------------------------------------------------------------------------------------------------
  Guam                    -          -       -         2         -          -        -           119         35
  P.R.                    -         43       -         -         -          -        -           734         46
  V.I.                    -          -       -         -         -          -        -             5          1
  C.N.M.I.                -          -       -        10         -          -        -            54         73
  American Samoa          -          -       -         1         -          -        -            55         17
----------------------------------------------------------------------------------------------------------------
* Rocky Mountain spotted fever.

====================================================================================================================================

NOTIFIABLE DISEASES -- reported cases, by geographic division and area, United States,
1993 (Page 6)
--------------------------------------------------------------------------------------------------------------------------------
                                  Syphilis
                       -------------------------------              Toxic-                                             Varicella
                       Primary &      Cong.      All                shock     Trich-   Tuber-                Typhoid   (chicken-
Area                   secondary    (<1 yr.)    stages   Tetanus   syndrome   inosis   culosis   Tularemia    fever      pox)
--------------------------------------------------------------------------------------------------------------------------------
United States           26,498 *     3,211 *   101,259 *   48        212        16     25,313       132        440      134,722
New England                330          17       1,713      2         13         -        649         -         31       12,655
  Maine                      7           -          19      -          3         -         27         -          -        1,733
  N.H.                      26           -          50      -          3         -         26         -          2        1,635
  Vt.                        1           -           1      -          1         -          7         -          -           NN
  Mass.                    122           6         935      2          5         -        370         -         23        6,619
  R.I.                      16           1         146      -          1         -         64         -          -        2,668
  Conn.                    158          10         562      -          -         -        155         -          6           NN
Mid. Atlantic            2,415       1,070      19,306      2         33         4      5,611         2        139        4,773
  N.Y. (excl. NYC)         258          94       1,980      -         17         4        718         2         20           NA
  N.Y.C.                 1,132         654      10,513      -          1         -      3,235         -         95        4,773
  N.J.                     328         161       2,556      -          -         -        912         -         18           NN
  Pa.                      697         161       4,257      2         15         -        746         -          6           NN
E.N. Central             4,070         527      11,789      7         48         2      2,385         5         40       64,380
  Ohio                   1,180          70       2,889      2         12         -        315         -          7        5,472
  Ind.                     362           1       1,019      1          1         -        248         1          2           NN
  Ill.                   1,489         368       4,881      1         11         2      1,242         3         23       26,447
  Mich.                    543          84       1,952      3         24         -        480         1          7       32,461
  Wis.                     496           4       1,048      -          -         -        100         -          1           NA
W.N. Central             1,631         111       3,271     10         15         -        582        39          2       16,814
  Minn.                     66           9         261      6          3         -        141         -          -           NN
  Iowa                      64           1         175      1          7         -         59         -          -        5,057
  Mo.                    1,354          97       2,500      1          2         -        257        17          2        9,609
  N. Dak.                    1           -           4      -          -         -          7         -          -           37
  S. Dak.                    2           -           3      -          -         -         16        17          -          420
  Nebr.                     14           1          35      -          -         -         22         2          -            4
  Kans.                    130           3         293      2          3         -         80         3          -        1,687
S. Atlantic              6,513         586      24,237      8         24         6      4,626         4         63        8,332
  Del.                      94           3         274      -          -         -         66         -          1            3
  Md.                      359          30       1,865      2          1         3        406         -          8           NN
  D.C.                     291          74       1,652      -          -         -        161         -          -            4
  Va.                      660          23       1,970      -          7         1        458         -          7        2,917
  W. Va.                     8           6         195      -          -         -         75         -          -        5,288
  N.C.                   1,937          54       4,448      -          4         -        594         2          3           NN
  S.C.                     921          82       2,339      1          -         -        401         -          -          120
  Ga.                    1,052          79       4,077      -          2         -        810         -          3           NN
  Fla.                   1,191         235       7,417      5         10         2      1,655         2         41           NN
E.S. Central             4,117         158      10,494      3         11         -      1,727         4          7        3,981
  Ky.                      331           9         651      -          3         -        405         1          2        1,429
  Tenn.                  1,156          52       3,241      2          4         -        556         2          2        2,552
  Ala.                     869          27       2,333      1          2         -        487         1          3           NN
  Miss.                  1,761          70       4,269      -          2         -        279         -          -           NN
W.S. Central             5,969         409      19,079      9          2         -      3,181        58         19       14,292
  Ark.                     559           8       1,600      1          -         -        209        36          2           NN
  La.                    2,598         144       6,854      -          -         -        367        --          1           NN
  Okla.                    282          11         721      1          2         -        209        17          1            -
  Tex.                   2,530         246       9,904      7          -         -      2,396         5         15       14,291
Mountain                   256          27       1,251      1         16         1        592        12         11        7,192
  Mont.                      1           -           4      -          -         -         22         5          -           84
  Idaho                      2           -          15      -          2         -         12         -          -           NN
  Wyo.                       4           -           9      -          -         1          7         3          -           NN
  Colo.                     90           8         287      1          2         -        102         1          5           NN
  N. Mex.                   34           -         172      -          1         -         74         -          2           NN
  Ariz.                     95          16         557      -          2         -        231         -          3        6,811
  Utah                      10           -          68      -          7         -         46         2          1          297
  Nev.                      20           3         139      -          2         -         98         1          -           NN
Pacific                  1,197         306      10,119      6         50         3      5,960         8        128        2,303
  Wash.                     67           4         360      1          7         -        286         2          8           NN
  Oreg.                     39           4         179      -          -         -        154         3          4           NN
  Calif.                 1,073         298       9,488      5         42         1      5,212         3        113           NN
  Alaska                    11           -          51      -          -         -         57         -          -           NN
  Hawaii                     7           -          41      -          1         2        251         -          3        2,303
--------------------------------------------------------------------------------------------------------------------------------
  Guam                       -           -           5      -          -         -         NA         -          4          553
  P.R.                     470          18       2,482      2          -         -        253         -          -