Clinical Care of Lyme Disease

Key points

  • Early diagnosis and proper antibiotic treatment of Lyme disease is important and can help prevent more serious forms of the disease.
  • The following treatment regimens reflect CDC’s interpretation of the most current data for four important manifestations of Lyme disease.
Doctor looking at a tablet

Treatment best practices

These regimens are consistent with guidance published by the by the Infectious Diseases Society of America, American Academy of Neurology, and American College of Rheumatology.

Some patients report prolonged symptoms of pain, fatigue, or difficulty thinking even after treatment for Lyme disease. The state of the science relating to prolonged symptoms associated with Lyme disease is limited, emerging, and unsettled. Additional research is needed to better understand how to treat, manage, and support people with prolonged symptoms associated with Lyme disease.