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CDC Zika Interim Response Plan


The purpose of this document is to describe the Centers for Disease Control and Prevention (CDC) response plan for locally acquired cases of Zika virus infection in the continental United States and Hawaii. Zika virus is spread to people primarily through the bite of an infected Aedes aegypti or Aedes albopictus mosquito. The response activities outlined in this plan are based on currently available knowledge about Zika virus and its transmission, and these activities may change as more is learned about Zika virus infection. Most of the plan focuses on response activities that would occur after locally acquired Zika virus transmission has been identified. CDC also is committed to responding to travel- associated and sexually transmitted Zika virus infections reported in the United States (US) before detection of locally transmitted cases of Zika virus infection.

Latest Changes

This CDC Interim Zika Response Plan replaces the previous documents posted on July 31 and September 30, 2016. Notable updates include:

  • Updated definition of Zika cautionary area (yellow area) to strengthen travel recommendations and reinforce recommendations for the use of protective measures to prevent exposure to Zika.
  • Revised guidance to ensure blood safety and availability, reflecting recommendations issued by the U.S. Food and Drug Administration (FDA) on August 26, 2016. [PDF - 17 pages]
  • Revised guidance on the determination of geographic areas for interventions and issuance of travel guidance in the setting of local transmission (Appendix A). CDC has identified two types of geographic areas: Zika active transmission areas (designated as red zones) and Zika cautionary areas (designated as yellow zones).
  • Updated status of Pregnancy and Birth Defects objectives (Appendix F).