Congenital Zika Syndrome & Other Birth Defects
Congenital Zika Syndrome
A pattern of other birth defects, called congenital Zika syndrome, has been found, which is unique to fetuses and infants infected with Zika virus before birth. Congenital Zika syndrome is described by the following five features:
- Severe microcephaly in which the skull has partially collapsed
- Decreased brain tissue with a specific pattern of brain damage, including subcortical calcifications
- Damage to the back of the eye, including macular scarring and focal pigmentary retinal mottling
- Congenital contractures, such as clubfoot or arthrogryposis
- Hypertonia restricting body movement soon after birth
Congenital Zika virus infection has also been associated with other abnormalities, including but not limited to brain atrophy and asymmetry, abnormally formed or absent brain structures, hydrocephalus, and neuronal migration disorders. Reported neurologic findings include, hyperreflexia, irritability, tremors, seizures, brainstem dysfunction, and dysphagia. Reported eye abnormalities include microphthalmia, lens subluxation, cataracts, intraocular calcifications, optic nerve atrophy, optic nerve hypoplasia and pallor, macular pallor, macular chorioretinitis, and chorioretinal atrophy. Other anomalies include excessive and redundant scalp skin.
Microcephaly is a congenital malformation resulting in smaller than normal head size for age and sex. It has also been associated with other birth defects and neurologic conditions in children and adults. For infants diagnosed with microcephaly, head size correlates with underlying brain size. However, these measurements do not consistently predict long term sequelae. Neurologic sequelae may include seizures, vision or hearing problems, and developmental disabilities. Symptoms vary with the extent of brain disruption.
There is now scientific consensus that Zika virus infection during pregnancy is a cause of microcephaly. We do not know if a newborn who gets Zika virus infection around the time of birth will develop microcephaly after birth. Babies can develop microcephaly after birth if their head growth slows or fails to develop. There have been no reports of Zika virus infection around the time of birth leading to microcephaly in infants.
Diagnosis of Microcephaly
Microcephaly is diagnosed when an infant’s head is smaller than expected as compared to infants of the same age (or gestational age) and sex. For the purpose of evaluating an infant for possible congenital Zika virus infection, microcephaly is defined as occipitofrontal circumference less than the third percentile, based on standard growth charts for sex, age, and gestational age at birth. For a diagnosis of microcephaly to be made, the occipitofrontal circumference should be disproportionately small in comparison with the length of the infant and not explained by other etiologies (e.g., other congenital disorders).
|Definite Congenital Microcephaly||
For Live Births: Head circumference (HC) at birth less than the 3rd percentile for gestational age and sex OR if HC at birth is not available, HC less than the 3rd percentile for age and sex within the first 2 weeks of life
For Stillbirths and Elective Terminations: HC at delivery less than the 3rd percentile for gestational age and sex
|Possible Congenital Microcephaly||
For Live Births: If earlier HC is not available, HC less than the 3rd percentile for age and sex beyond 6 weeks of life
For All Pregnancy Outcomes: Microcephaly diagnosed or suspected on prenatal ultrasound in the absence of available postnatal HC measurements
Charts for Head Circumference at Birth
|Gestational Age||INTERGROWTH-21st Fetal Growth Standard for Head Circumference at Birth|
|33–43 Weeks||Newborn Size at Birth Chart and tool for calculating centiles for head circumference for infants 33–42 weeks|
|24–32 Weeks||Very Preterm Size at Birth References and tool for calculating centiles for head circumference for infants 24–32 weeks|
|<24 Weeks||Fetal Growth Standards|
INTERGROWTH-21st Fetal Growth Standards are based on measurements in utero only. International standards for birth measurements in infants less than 24 weeks gestation are not available. For most elective pregnancy terminations and many stillbirths, accurate postnatal head circumference measurements are not possible.
For a study comparing head circumference measurements in utero to those obtained after birth, see: Melamed N, Yogev Y, Danon D, et al. Sonographic estimation of fetal head circumference: how accurate are we? Ultrasound Obstet Gynecol 2011;37:65-71.
In the setting of Zika virus infection, the head circumference might be disproportionately small in comparison with the length of the infant and not explained by other etiologies. View more information about Zika Virus Infection and Microcephaly.
Measuring Head Circumference
Head circumference (occipitofrontal circumference) measurements should be taken using a tape measure that cannot be stretched. The tape is securely wrapped around the widest possible circumference of the head, 1–2 finger widths above the eyebrow on the forehead and at the most prominent part of the back of the head. Ideally, the measurement should be taken 3 times and the largest measurement recorded to the nearest 0.1 cm. It may be helpful to have the parent or nurse hold the infant’s arms.
Although head circumference measurements may be influenced by molding and other factors related to delivery, the measurements should be taken on the first day of life because commonly-used birth head circumference reference charts by age and sex are based on measurements taken before 24 hours of age. The most important factor is that the head circumference is carefully measured and documented. If measurement within the first 24 hours of life is not done, the head circumference should be measured as soon as possible after birth.
- Vital Signs: Update on Zika Virus–Associated Birth Defects and Evaluation of All U.S. Infants with Congenital Zika Virus Exposure — U.S. Zika Pregnancy Registry, 2016 (MMWR, 2017)
- Baseline Prevalence of Birth Defects Associated with Congenital Zika Virus Infection — Massachusetts, North Carolina, and Atlanta, Georgia, 2013–2014 (MMWR, 2017)
- Facts about Microcephaly
- Zika virus and birth defects – Reviewing the evidence for causality (NEJM, 2016)
- Page last reviewed: April 28, 2017
- Page last updated: April 28, 2017
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