Healthcare Providers Caring for Infants & Children
Note: CDC has published updated Interim Guidance for the Diagnosis, Evaluation, and Management of Infants with Possible Congenital Zika Virus Infection. This page is in the process of being updated with these new recommendations.
- All infants born to mothers who have laboratory evidence of Zika virus infection during pregnancy should receive comprehensive physical exam, neurologic assessment, head ultrasound, standard newborn hearing assessment, and Zika virus testing.
- Testing is recommended for infants born to mothers who have laboratory evidence of Zika virus infection during pregnancy and for infants who have abnormal clinical findings suggestive of congenital Zika syndrome and a maternal epidemiologic link suggesting possible exposure during pregnancy, regardless of maternal test results.
- A Zika virus RNA NAT test should be performed on both infant serum and urine, and Zika virus immunoglobulin M (IgM) antibody should be performed on infant serum. Testing should be performed on specimens collected from infants within 2 days after birth; however, testing specimens collected within the first few weeks to months after birth may still be useful in the evaluation for possible congenital Zika virus infection, especially among infants born in areas without risk of Zika.
- Guidance for testing and clinical management of infants and children with postnatal Zika virus infection is in line with testing and clinical management recommendations for adults.
- Zika testing is recommended during the first 2 weeks after symptom onset to diagnose postnatal Zika virus infection. Serologic testing is recommended 2-12 weeks after symptom onset.
- NEW – Update: Interim Guidance for the Diagnosis, Evaluation, and Management of Infants with Possible Congenital Zika Virus Infection — United States, October 2017 (MMWR, Oct. 19, 2017)
- UPDATE: Interim Guidance for the Evaluation and Management of Infants with Possible Congenital Zika Virus Infection – United States, August 2016 (MMWR, August 19, 2016)
- UPDATE: Interim Guidelines for Healthcare Providers Caring for Infants and Children with Possible Zika Virus Infection – United States, February 2016 (MMWR, Feb. 19, 2016)
- Interim Guidelines for the Evaluation and Testing of Infants with Possible Congenital Zika Virus Infection – United States, 2016 (MMWR, Jan. 29, 2016)
- Page last reviewed: October 19, 2017
- Page last updated: October 19, 2017
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