Hib Vaccine Recommendations

Below are summaries of recommendations from CDC’s Advisory Committee on Immunization Practices (ACIP). For the full text of the recommendations, see Haemophilus influenzae type b (Hib) ACIP Vaccine Recommendations.

Routine Vaccination of Infants and Children

CDC recommends routine administration of a conjugate Hib vaccine series beginning at age 2 months (Table 1):

  • Infants 2 through 6 months of age should receive either:
    • A 3-dose series of Hib PRP-T as ActHib®, Hiberix®, or Pentacel®
    • A 2-dose series of Hib PRP-OMP as PedvaxHib®
  • You can administer the first dose as early as age 6 weeks.
  • CDC recommends a booster dose of any licensed conjugate Hib vaccine at age 12 through 15 months.
    • Administer the booster dose at least 8 weeks after the most recent Hib vaccination.
    • The booster dose will be dose 3 or 4 depending on vaccine type used in the primary series.

Catch-up Guidance for Children 4 Months through 18 Years

The following “job-aids” provide catch-up guidance for Hib vaccination for children 4 months through 18 years of age. They include detailed scenarios by age group and previous number of doses received. These materials should assist healthcare professionals in interpreting Figure 2 of the Childhood/Adolescent Immunization Catch-up Schedule.

Contraindications and Precautions

You should not administer Hib vaccines to:

  • A person who has ever had a severe allergic reaction (e.g., anaphylaxis) after a previous dose
  • A person who has a severe allergy to any vaccine component
  • A person younger than 6 weeks

You may administer Hib vaccines, if you and the parent or patient deem the benefits of vaccination to outweigh the risks, to:

  • A person who has a moderate or severe acute illness with or without fever

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Page last reviewed: February 13, 2018