Pfizer-BioNTech COVID-19 Vaccine (Purple Cap) Age 12 and Over

Summary of Recent Changes and Updates

Webpage content and individual PDFs are updated when there’s new guidance concerning the Pfizer-BioNTech COVID-19 Vaccine. Expand each section below to see a summary of new and updated items.

General Pfizer-BioNTech Vaccine Information

Vaccine: Pfizer-BioNTech COVID-19 Vaccine (purple cap)

Diluent: 1.8 mL of 0.9% sodium chloride (normal saline, preservative-free)

Discard vial when there is not enough vaccine to obtain a complete dose. Do NOT combine residual vaccine from multiple vials to obtain a dose.

Administration Overview

Before administering vaccine, screen recipients for contraindications and precautions, even if the recipient is schedule to receive the second dose. The recipient’s health condition or recommendations regarding contraindications and precautions for vaccination may change from one visit to the next.

To assess recipients correctly and consistently, vaccination providers should use a standardized, comprehensive screening tool.

Contraindications and Precautions
How to Thaw, Prepare, and Administer the Pfizer-BioNTech Vaccine
laptop solid icon
Document the Vaccination

COVID-19 vaccination providers must document vaccine administration in their medical record systems within 24 hours of administration and use their best efforts to report administration data to the relevant system for the jurisdiction (i.e., immunization information system) as soon as practicable and no later than 72 hours after administration.

Storage and Handling Overview
weather icon

Store vaccine in an ultra-cold freezer, freezer, thermal shipping container, or refrigerator.
See guidance below for each storage unit.

  • Vaccine will arrive at a temperature between -90°C and -60°C (-130°F to -76°F) in a thermal shipping container with dry ice. The vial for people 12 years of age and older has a purple cap and purple border on the label.
  • Diluent and an ancillary supply kits will arrive separately from the vaccine.
  • Unpack the thermal shipping container following the manufacturer’s directionsexternal icon.
How to Store the Pfizer-BioNTech COVID-19 Vaccine
comment alt lines light icon
Report Adverse Events

Adverse events that occur in a recipient after COVID-19 vaccination are required to be reported to the Vaccine Adverse Event Reporting System (VAERS). FDA requires vaccination providers to report vaccine administration errors, serious adverse events, cases of multisystem inflammatory syndrome, and cases of COVID-19 that result in hospitalization or death after administration of COVID-19 vaccine under an EUA. Reporting is encouraged for other clinically significant adverse events, even if it is not clear that a vaccine caused the adverse event. Complete and submit reports to VAERS onlineexternal icon.

For further assistance with reporting to VAERS, call 1-800-822-7967.

hand holding medical light icon
What to Expect after a COVID-19 Vaccination

Print informationpdf icon for your patients on common side effects, helpful tips, and when to call a doctor after a COVID-19 vaccination.

email_03Get Email Updates

To receive email updates about this page, enter your email address:

Page last reviewed: April 25, 2022