COVID-19 Vaccination Program Operational Guidance
CDC Fall Vaccination Operational Planning Guides
On June 30, 2022, the U.S. Food and Drug Administration (FDA) advised manufacturers seeking to update their COVID-19 vaccines to add an Omicron BA.4/5 spike protein component to the current vaccine composition to create a bivalent booster vaccine. This operational planning guide includes details about the bivalent COVID-19 booster.
CDC Fall COVID-19 Vaccination Operational Planning Guide: Children Aged 5-11 Years (9/20/22)
Single-Dose Vials – Pfizer (12+) Updated COVID-19 Vaccine
The following document provides information on single-dose vials of the updated (bivalent) Pfizer-BioNTech COVID-19 vaccine for people 12 years of age and older. Single-dose vials are available for ordering, providing greater flexibility for vaccine administration partners to expand access and availability of the updated vaccine.
CDC Novavax COVID-19 Vaccination Operational Planning Guide
On July 13, 2022, the U.S. Food and Drug Administration (FDA) issued an Emergency Use Authorization (EUA) for Novavax COVID-19 vaccine for use among people ages 18 years and older for primary series vaccination. On July 19, 2022, CDC’s Advisory Committee on Immunization Practices (ACIP) recommended use of the Novavax COVID-19 vaccine in this population. The Novavax COVID-19 vaccine is administered as a two-dose primary series, with the doses given 3 weeks apart. A limited number of doses of Novavax COVID-19 vaccine will be distributed and not all providers are expected to carry Novavax COVID-19 vaccine. This operational planning guide includes details about the Novavax product.
The COVID-19 Vaccination Program Interim Operational Guidance for Jurisdictions Playbook
The interim playbook serves as an interim playbook for state, territorial (including the U.S.-affiliated Pacific Islands [USAPI], tribal, and local public health programs and their partners on how to plan and operationalize a vaccination response to COVID-19 within their jurisdictions. Many, but not all, of the COVID-19 Vaccination Program activities described may overlap with routine activities; routine immunization and pandemic influenza program activities can serve as a foundation for COVID-19 vaccination planning.
Download the most up-to-date playbook.
Download the most up-to-date annex.
- New guidance and considerations to jurisdictions regarding when and how to transition from vaccinating initial populations of focus to reaching and increasing uptake in additional priority populations
- A framework for balancing equitable access, service delivery, and vaccine demand
- Tools for engaging priority populations and increasing vaccine confidence
- Strategies for leveraging private-public partnerships
Key Operational Considerations for Jurisdictions Planning to Operate COVID-19 Vaccination Clinics
This guidance provides information that informs the planning and operations of all types and sizes of vaccination clinics, including key considerations to maximize throughput at vaccination sites in large venues, drive-through vaccination clinics, and smaller-scale mobile vaccination venues.
- "COVID 3" Vaccination Supplemental FundingFunding for the implementation and expansion of the COVID-19 vaccination program
- Performance Measures for COVID-19 Cycle 3 Supplemental Funding
Performance measures for the COVID-19 January 2021 supplemental funding
- Performance Measures for COVID-19 Cycle 3 Supplemental Funding
- "COVID 4 Vaccination Supplemental Funding” Equity and Prioritizing Populations Disproportionately Affected by COVID-19Guidance for the use of supplement 4 funding for IP19-1901 Immunization and VFC cooperative agreement recipients
- "COVID 4 Addendum" Supplemental Funding for Vaccine Confidence
- ELC and 317/VFC Cooperative Agreement COVID Funding Allowable ExpensesELC Enhancing Detection expansion and Immunization cooperative agreement COVID-19 funding supplementals
- IP19-1901 COVID Vaccination Incentive Policy
- IP19-1901 COVID Vaccination Incentive Policy FAQs
- Immunization and Vaccines for Children Program Funding Resources