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In general, people at high risk for developing TB disease once infected with M. tuberculosis include:


         People living with HIV/AIDS


         Children younger than 5 years of age


         Persons who are receiving immunosuppressive therapy


         Persons who were recently infected with M. tuberculosis (within the past 2 years)


         Persons with a history of untreated or inadequately treated TB disease


         Persons with silicosis, diabetes, chronic renal failure, leukemia, lymphoma, or cancer of the head, neck, or lung


         Persons who have had a gastrectomy or jejunoileal bypass


         Persons who weigh less than 90% of their ideal body weight


         Cigarette smokers and persons who abuse drugs or alcohol


         Populations defined locally as having an increased incidence of TB disease, possibly including medically underserved or low-income populations

Silicosis: A lung disease caused by inhaling silica dust; occurs most often in mining workers.

Immunosuppressive therapy:Therapy that weakens the immune system, including prolonged use of corticosteroids and tumor necrosis factor-alpha antagonists.

Jejunoileal bypass: A surgical operation performed to reduce absorption in the small intestine.

Gastrectomy: A partial or full surgical removal of the stomach.