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In general, people at high risk for developing TB disease once infected with M. tuberculosis include:

 

         People living with HIV/AIDS

 

         Children younger than 5 years of age

 

         Persons who are receiving immunosuppressive therapy

 

         Persons who were recently infected with M. tuberculosis (within the past 2 years)

 

         Persons with a history of untreated or inadequately treated TB disease

 

         Persons with silicosis, diabetes, chronic renal failure, leukemia, lymphoma, or cancer of the head, neck, or lung

 

         Persons who have had a gastrectomy or jejunoileal bypass

 

         Persons who weigh less than 90% of their ideal body weight

 

         Cigarette smokers and persons who abuse drugs or alcohol

 

         Populations defined locally as having an increased incidence of TB disease, possibly including medically underserved or low-income populations

Silicosis: A lung disease caused by inhaling silica dust; occurs most often in mining workers.

Immunosuppressive therapy:Therapy that weakens the immune system, including prolonged use of corticosteroids and tumor necrosis factor-alpha antagonists.

Jejunoileal bypass: A surgical operation performed to reduce absorption in the small intestine.

Gastrectomy: A partial or full surgical removal of the stomach.