Annual prevalence of high-grade histologically-detected cervical intraepithelial neoplasia grades 2 and 3 (CIN2+) during 2007–2014 was estimated using health-care claims from 9 million females aged 15–39 years who received cervical cancer screening in a given calendar year. Prevalence of CIN2+ decreased significantly in females aged 15–19 and 20–24 years. Among those aged 15–19 years, annual percent change (APC) in CIN2+ prevalence was -19.8% during 2007–2009 and -12.1% during 2009–2014. For women aged 20–24 years, APC was -6.7% during 2007– 2012, and -12.5% during 2012–2014. No decreases in CIN2+ prevalence were observed among women aged 25–39 years.