Two-panel figure showing resistance or elevated minimum inhibitory concentration patterns of Neisseria gonorrhoeae isolates to antimicrobials during 2018. The different susceptibility patterns seen in GISP in 2018 are shown. Panel A, a pie graph, demonstrates the percentage of Neisseria gonorrhoeae isolates with resistance or elevated minimum inhibitory concentrations to azithromycin, cefixime, ceftriaxone, fluoroquinolone, tetracycline, and penicillin. Panel B, an UpSet graph, further highlights the specific combinations of resistance or elevated minimum inhibitory concentrations across antimicrobials (vertical bars). The overall percentage of reduced susceptibility for each antimicrobial (horizontal bars) are the same percentages seen for 2018 in Figure 31. Of all the Neisseria gonorrhoeae isolates collected in GISP in 2018, 4.5% demonstrated resistance or elevated minimum inhibitory concentrations to at least three antibiotics tested with the majority of the combinations including tetracycline, penicillin and ciprofloxacin; no isolates with elevated azithromycin minimum inhibitory concentrations had elevated ceftriaxone minimum inhibitory concentrations. In 2018, 48.7% of all tested isolates were susceptible to all antibiotics tested.