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    Vaccination Information

    image of pox vaccination kit

    Learn more…

    Smallpox Vaccination with ACAM2000 Videos

    Clinician demonstrates the proper way to administer the smallpox vaccine using a bifurcated needle. Source: CDC's James Gathany.

    Instructional videos: Learn how to administer ACAM2000 smallpox vaccine

    Evaluating Patients for Smallpox

    Evaluating Patients for Smallpox: Acute, Generalized Vesicular or Pustular Rash Illness Protocol poster. Follow link to poster explanation

    Learn more…

    Images of Vaccine Reactions
    • Comparison of Reactions for First-Time Vaccinees and Revaccinees
    • Examples of Major or "Take" Reactions to Smallpox Vaccination
    • Vaccine Adverse Reaction Images

    Resources
    • CDC Interim Guidance for Revaccination of Eligible Persons Who Participated in the US Civilian Smallpox Preparedness and Response Program pdf icon[PDF – 5 pages]
    • Occupational Exposure to Orthopoxviruses Among Laboratory Personnel
    • Specimen Collection
    • Packaging and Transporting Infectious Substances

    Page last reviewed: October 8, 2019
    Content source: Centers for Disease Control and Prevention, National Center for Emerging and Zoonotic Infectious Diseases (NCEZID), Division of High-Consequence Pathogens and Pathology (DHCPP)
    home Smallpox
    • About Smallpox
    • History of Smallpox expand
      • Spread and Eradication of Smallpox
    • Transmission
    • Signs and Symptoms
    • Prevention and Treatment
    • Smallpox Vaccine Basics expand
      • Vaccine Safety
      • Side Effects of Vaccination
      • Who Should Get a Smallpox Vaccination?
    • Bioterrorism expand
      • The Threat
      • Preparedness
      • Detection and Response
    • Bioterrorism Response Planning expand
      • Community-Based Planning for a Smallpox Emergency expand
        • Build Community Partnerships
        • Identify Resources and Needs
        • Help People with Functional, Language, or Cognitive Needs
      • Public Health Response Activities expand
        • Identify, Diagnose, and Isolate Cases
        • Enhanced Surveillance and Case Reporting
        • Epidemiological Investigation
        • Vaccination Strategies
        • Ring Vaccination
        • Community-Wide (Mass) Vaccination expand
          • Download Maxi-Vac Version 1.0 and Maxi-Vac Alternative
          • Description of Maxi-Vac Programs
          • Differences Between Maxi-Vac Version 1 and Alternative Version
        • Communication expand
          • Sample Alert Messages for Healthcare Providers
          • Sample Alert Messages for the Community
        • Information Management
      • Healthcare Facility Response Activities expand
        • Protect and Care for Smallpox Patients
        • Vaccinate Your Staff
        • Care for Your Staff
        • Prevent Spread of Disease
    • Research
    • For Clinicians expand
      • Transmission
      • Clinical Disease
      • Diagnosis & Evaluation expand
        • Evaluating Patients for Smallpox
      • Treatment
      • Vaccination expand
        • Vaccines
        • Contraindications to Vaccination
        • Vaccine Administration
        • Expected Vaccine Reactions
        • Vaccine “Take” Evaluation
        • Vaccine Adverse Events
        • Medical Management of Adverse Reactions
        • Comparison of Reactions for First-Time Vaccinees and Revaccinees
        • Examples of Major or “Take” Reactions to Smallpox Vaccination
        • Vaccine Adverse Reaction Images
      • Administering ACAM2000 Smallpox Vaccine Videos
    • Laboratory Personnel expand
      • Specimen Collection expand
        • Specimen Collection and Transport Guidelines for Suspect Smallpox Cases
        • Specimen Collection and Transport Guidelines for Suspect Smallpox Vaccine Adverse Events
        • Specimen Collection Procedures
        • Negative Staining Electron Microscope Protocol for Rash Illness
      • Packaging and Transporting Infectious Substances
      • Rash Illness Protocol expand
        • Chart 1: Acute, Generalized Vesicular or Pustular Rash Illness Protocol
        • Chart 2: Laboratory Testing for Acute, Generalized Vesicular or Pustular Rash Illness
        • Chart 3: Laboratory Testing for Suspect Smallpox Vaccine Adverse Event (Vaccinia)
        • Chart 4: Laboratory Testing for Environmental Sample
    Related Links
    • WHO Smallpox WebsiteExternal file_external
    • NIH Smallpox ResearchExternal file_external
    • CDC Poxvirus and Rabies Branch
    • Poxvirus Diseases
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