Resources for Public Health & Medical Professionals
Water or bloody diarrhea, abdominal pain, tenesmus, fever, and malaise. Stools tend to be of small volume, and severe dehydration is uncommon.
Four species of Shigella: sonnei, flexneri, dysenteriae, and boydii.
In the United States, there are about 500,000 cases of shigellosis every year, making it the third most common bacterial enteric disease 1. Shigellosis does not have a marked seasonality, likely reflecting the importance of person-to-person transmission. For more information, see the FoodNet 2012 Surveillance Report. Cdc-pdf[PDF – 36 pages]
Possible complications from Shigella infections include:
- Post-infectious arthritis. A syndrome of joint pains, eye irritation, and painful urination after an infection is called post-infectious arthritis. This can happen in about 2% 3-6 of persons who are infected with Shigella flexneri. Few cases have been reported in association with S. sonnei 7, 8 or S. dysenteriae infection 9. It can last for months or years, and can lead to chronic arthritis. Post-infectious arthritis is caused by a reaction to Shigella infection that happens only in people who are genetically predisposed to it 3, 10-12.
- Blood stream infections. Although rare, blood stream infections are caused either by Shigella organisms or by other germs in the gut that get into the bloodstream when the lining of the intestines is damaged during shigellosis. Blood stream infections are most common among patients with weakened immune systems, such as those with HIV, cancer, or severe malnutrition 10, 13, 14.
- Seizures. Generalized seizures have been reported occasionally among young children with shigellosis, and usually resolve without treatment. Children who experience seizures while infected with Shigella typically have a high fever or abnormal blood electrolytes (salts), but it is not well understood why the seizures occur 10, 15-19.
- Hemolytic-uremic syndrome or HUS. HUS occurs when bacteria enter the digestive system and produce a toxin that destroys red blood cells. Patients with HUS often have bloody diarrhea. HUS is only associated with Shiga-toxin producing Shigella, which is most commonly Shigella dysenteriae 10, 20-22.
Shigella is very contagious; a small inoculum (10 to 200 organisms) is sufficient to cause infection 23. Shigella germs are present in the stools of infected persons while they have diarrhea and for up to a few weeks after the diarrhea has gone away 24. Transmission of Shigella occurs when people put something in their mouths or swallow something that has come into contact with stool of a person infected with Shigella. This can happen when:
- Contaminated hands touch your food or mouth. Hands can become contaminated through a variety of activities, such as touching surfaces (e.g., toys, bathroom fixtures, changing tables, diaper pails) that have been contaminated by stool from an infected person. Hands can also become contaminated with Shigella while changing the diaper of an infected child or caring for an infected person.
- Eating food contaminated with Shigella. Food may become contaminated if food handlers have shigellosis. Produce can become contaminated if growing fields contain human sewage 25. Flies can breed in infected feces and then contaminate food when they land on it.
- Swallowing recreational (for example, lake or river water while swimming) or drinking water that was contaminated by infected fecal matter.
- Exposure to feces through sexual contact.
- Young children are the most likely to get shigellosis, but people from all age groups are affected 26. Many outbreaks are related to childcare settings and schools, and illness commonly spreads from young children to their family members and others in their communities because it is so contagious.
- Gay, bisexual, and other men who have sex with men (MSM)† are more likely to acquire shigellosis than the general adult population 27. Shigella passes from stools or soiled fingers of one person to the mouth of another person, which can happen during sexual activity. Many shigellosis outbreaks among MSM have been reported in the United States, Canada, Japan, and Europe since 1999 28-35. Resistance to clinically important antimicrobials may also be more prevalent among shigellae isolated from MSM 27-29, 31-34, 36, 37. For more information, see Shigella Infections among Gay & Bisexual Men.(https://www.cdc.gov/shigella/msm.html)
- HIV-infected persons can have more severe and prolonged shigellosis, including having the infection spread into the blood, which can be life-threatening 30, 38.
- Large outbreaks of Shigella have occurred in traditionally observant Jewish communities 39-41. Documented outbreaks in traditionally observant Jewish communities often begin in childcare settings and spread within and between households during social gatherings.
- Travelers to developing countries may be more likely to get shigellosis, and to become infected with strains of Shigella that are resistant to important antibiotics 34, 35, 42-45. Travelers may be exposed through contaminated food, water (both drinking and recreational water), or surfaces. Travelers can protect themselves by strictly following food and water precautions, and washing hands with soap frequently. For more information, see Travelers’ Health – Food and Water Safety.
† The term men who have sex with men is used in CDC surveillance systems because it indicates the behaviors that transmit Shigella infection, rather than how individuals self-identify in terms of their sexuality.
Resistance to traditional first-line drugs such as ampicillin and trimethoprim-sulfamethoxazole is common. Healthcare providers now rely on alternative drugs like ciprofloxacin and azithromycin to treat infections. However, strains of Shigella resistant to these antibiotics are becoming more common in the United States 46. Infections caused by antibiotic-resistant Shigella strains can last longer than infections caused by antibiotic-susceptible bacteria 47. Because initial treatment can fail and effective treatments may require intravenous or intramuscular administration, costs are expected to be higher for resistant infections 47.
For more information, see Antibiotic / Antimicrobial Resistance.
Clinical laboratories report isolations of Shigella to state health departments, which then report tem to CDC. Shigellosis is a notifiable infectious disease.
Reports trends in foodborne infections and tracks the impact of food safety policies nationally.
Foodborne Diseases Active Surveillance Network (FoodNet), conducts surveillance for Campylobacter, Cryptosporidium, Cyclospora, Listeria, Salmonella, Shiga toxin-producing Escherichia coli (STEC) O157 and non-O157, Shigella, Vibrio, and Yersinia infections diagnosed by laboratory testing of samples from patients.
The network, established in July 1995, is a collaborative program among CDC, 10 state health departments, the U.S. Department of Agriculture’s Food Safety and Inspection Service (USDA-FSIS)External, and the Food and Drug Administration (FDA)External. FoodNet personnel in state health departments get timely reports of infections diagnosed in residents of ConnecticutExternal, GeorgiaExternal, MarylandExternal, MinnesotaExternal, New MexicoExternal, OregonExternal, TennesseeExternal and selected counties in CaliforniaExternal, ColoradoExternal, and New YorkExternal and are in regular contact with the clinical laboratories serving these areas. The surveillance area includes 15% of the United States population (about 49 million persons). FoodNet is the principal foodborne disease component of CDC’s Emerging Infections Program.
Collects laboratory data, such as serotype, on Shigella
National Shigella surveillance data are collected through passive surveillance of laboratory-confirmed human Shigella infections. Clinical diagnostic laboratories submit Shigella isolates to state and territorial public health laboratories, where they are confirmed, speciated, and subtyped. Unusual or untypable serotypes are forwarded to the Centers for Disease Control and Prevention’s (CDC) National Shigella Reference Laboratory at the Enteric Diseases Laboratory Branch (EDLB) for further characterization or confirmation; results are reported back to state and territorial public health laboratories.
State and territorial public health laboratories report Shigella infections electronically to CDC through a variety of mechanisms. Data are collected into the Laboratory-based Enteric Disease Surveillance (LEDS) system. The Division of Foodborne, Waterborne, and Environmental Diseases (DFWED) in the National Center for Emerging and Zoonotic Infectious Diseases maintains the national Shigella surveillance data in LEDS. The annual summaries of these data are the only regularly published national source of serotype information for Shigella.
For more information, see Foodborne Illness Surveillance, Response, and Data Systems.
Tracking trends in resistance
The National Antimicrobial Resistance Monitoring System for Enteric Bacteria (NARMS) is an interagency public health surveillance system that tracks antimicrobial resistance in foodborne and other enteric (intestinal) bacteria from humans, retail meats, and food animals in the United States. The NARMS program at CDC helps protect public health by providing information about resistance in bacteria isolated from ill people, the ways in which resistance is spread, and how resistant infections differ from susceptible infections.
- CDC. NARMS Human Isolates Reports
- FDA. NARMS Retail Meat Isolates Reports and NARMS Interagency Executive Reports (FDA website)External
- USDA. NARMS Animal Isolates ReportsExternal
For more information, see National Antimicrobial Resistance Monitoring System (NARMS).
The National Notifiable Disease Surveillance System, or NNDSS, tracks contagious diseases that laboratory professionals and doctors are required to report to the state or territorial public health agency. These agencies voluntarily submit the information to NNDSS, which CDC oversees. Notifiable disease surveillance is “passive” (i.e., the investigator at CDC waits for disease reports from those requested to report) and is susceptible to underreporting. Foodborne diseases that are nationally notifiable include botulism, hemolytic uremic syndrome (HUS), listeriosis (Listeria), shigellosis (Shigella), salmonellosis (Salmonella), Shiga Toxin-producing Escherichia coli (STEC) infections, cryptosporidiosis and vibriosis (cholera and its relatives).
For more information, see National Notifiable Diseases Surveillance System (NNDSS).
The National Outbreak Reporting System, or NORS, is a web-based platform designed to support reporting to CDC by local, state, and territorial health departments in the United States of all waterborne disease outbreaks and enteric disease outbreaks transmitted by food, contact with environmental sources, infected persons or animals, or unknown modes of transmission.
For more information, see The National Outbreak Reporting System (NORS).
To find outbreaks, see the Foodborne Outbreak Online Database (FOOD).
Connects cases of illness nationwide to quickly identify outbreaks, including many that would otherwise go undetected
The National Molecular Subtyping Network for Foodborne Disease Surveillance, or PulseNet, connects cases to potential outbreaks, especially across states. PulseNet has revolutionized the detection and investigation of foodborne disease outbreaks, especially those occurring in multiple sites across the country which, before PulseNet, often went undetected or were detected only after they grew very large. The PulseNet USA network of 83 local, state, territorial, agricultural, and federal laboratories in all 50 states is coordinated by CDC along with the Association of Public Health Laboratories (APHL). PulseNet International has 7 regions in 88 countries. Each laboratory tests enteric bacteria that cause illness, like E. coli and Shigella, through a standardized subtyping process using multiple analytical tools, including pulsed-field gel electrophoresis (PFGE)*, multiple locus variable number tandem repeat analysis (MLVA), and whole genome sequencing (WGS). All of these techniques are used to determine the DNA fingerprint of the bacteria.
*Public health scientists upload these different fingerprints (such as PFGE patterns, MLVA profiles, and DNA sequences) to their respective electronic databases to compare them to fingerprints isolated from other people, animals, and foods to identify matches that may indicate an outbreak is happening.
- Follow diapering procedures that will minimize exposure to germs that cause diarrhea. Please see Diaper-Changing Steps for Childcare Settings for more information.
- National Resource Center. Environmental Health in Early Care and Education Manual Cdc-pdf[PDF – 55 pages]External
- American Academy of Pediatrics (AAP):
- Early Childhood Education Linkage System
- CDC Fact Sheet: Shigella Infections among Gay & Bisexual Men
- Minnesota Department of Health. Shigellosis Fact Sheet for MSM Cdc-pdf[PDF – 2 pages]External
- Public Health England. Good Session? Bad Case of Diarrhoea? Maybe It’s Shigella Cdc-pdf[PDF – 2 pages]External
Below you will find useful links related to hygiene and handwashing in the food service industry.
- Scallan E, Hoekstra RM, Angulo FJ, Tauxe RV, Widdowson MA, Roy SL, Jones JL, Griffin PM. Foodborne illness acquired in the United States–major pathogens. Emerg Infect Dis. 2011;17(1):7-15.
- Crim SM, Iwamoto M, Huang JY, Griffin PM, Gilliss D, Cronquist AB, Cartter M, Tobin-D’Angelo M, Blythe D, Smith K, Lathrop S, Zansky S, Cieslak PR, Dunn J, Holt KG, Lance S, Tauxe R, Henao OL. Incidence and trends of infection with pathogens transmitted commonly through food–Foodborne Diseases Active Surveillance Network, 10 U.S. sites, 2006-2013. MMWR Morb Mortal Wkly Rep. 2014;63(15):328-32.
- Simon DG, Kaslow RA, Rosenbaum J, Kaye RL, Calin A. Reiter’s syndrome following epidemic shigellosisExternal J Rheumatol. 1981;8(6):969-73.
- Noer HR. An “experimental” epidemic of Reiter’s Syndrome.External JAMA. 1966;198(7):693-8.
- Finch M, Rodey G, Lawrence D, Blake P. Epidemic Reiter’s syndrome following an outbreak of shigellosis. Eur J Epidemiol. 1986;2(1):26-30.
- Van Bohemen CG, Lionarons RJ, van Bodegom P, Dinant HJ, Landheer JE, Nabbe AJ, Grumet FC,and Zanen HC. Susceptibility and HLA-B27 in post-dysenteric arthropathies.External Immunology. 1985;56(2):377-9.
- Lauhio A, Lahdevirta J, Janes R, Kontiainen S, Repo H. Reactive arthritis associated with Shigella sonnei infection. Arthritis Rheum. 1988;31(9):1190-3.
- Chen M, Delpech V, O’Sullivan B, Donovan B. Reactive arthritis associated with Shigella sonnei infection.External Int J STD AIDS. 2002;13(2):135-6.
- Mazumder RN, Salam MA, Ali M, Bhattacharya MK. Reactive arthritis associated with Shigella dysenteriae type 1 infection.External J Diarrhoeal Dis Res. 1997;15(1):21-4.
- American Academy of Pediatrics. Red Book: Report of the Committee on Infectious Diseases. 2012. 645-647.
- Morse HG, Rate RG, Bonnell MD, Kuberski TT. Reiter’s syndrome in a five-year-old girl. Arthritis Rheum. 1980;23(8):960-1.
- Hannu T, Mattila L, Siitonen A, Leirisalo-Repo M. Reactive arthritis attributable to Shigella infection: a clinical and epidemiological nationwide study.External Ann Rheum Dis. 2005;64(4):594-8.
- Morduchowicz G, Huminer D, Siegman-Igra Y, Drucker M, Block CS, Pitlik SD. Shigella bacteremia in adults. A report of five cases and review of the literature.External Arch Intern Med. 1987;147(11):2034-7.
- Appannanavar SB, Goyal K, Garg R, Ray P, Rathi M, Taneja N. Shigellemia in a post renal transplant patient: a case report and literature review.External J Infect Dev Ctries. 2014;8(2):237-9.
- Goldberg EM, Balamuth F, Desrochers CR, Mittal MK. Seizure and altered mental status in a 12-year-old child with Shigella sonnei gastroenteritis.External Pediatr Emerg Care. 2011;27(2):135-7.
- Lahat E, Katz Y, Bistritzer T, Eshel G, Aladjem M. Recurrent seizures in children with Shigella-associated convulsions.External Ann Neurol. 1990;28(3):393-5.
- Khan WA, Dhar U, Salam MA, Griffiths JK, Rand W, Bennish ML. Central nervous system manifestations of childhood shigellosis: prevalence, risk factors, and outcome.External Pediatrics. 1999;103(2):E18.
- Galanakis E, Tzoufi M, Charisi M, Levidiotou S, Papadopoulou ZL. Rate of seizures in children with shigellosis.External Acta Paediatr. 2002;91(1):101-2.
- Shamsizadeh A, Nikfar R, Bavarsadian E. Neurological manifestations of shigellosis in children in southwestern IranExternal. Pediatr Int. 2012;54(1):127-30.
- Butler T. Haemolytic uraemic syndrome during shigellosis.External Trans R Soc Trop Med Hyg. 2012;106(7):395-9.
- Rahaman MM, Greenough WB, 3rd. Shigellosis and haemolytic uraemic syndrome. Lancet. 1978;1(8072):1051.
- Bloom PD, MacPhail AP, Klugman K, Louw M, Raubenheimer C,and Fischer C. Haemolytic-uraemic syndrome in adults with resistant Shigella dysenteriae type I.External Lancet. 1994;344(8916):206.
- DuPont HL, Levine MM, Hornick RB, Formal SB. Inoculum size in shigellosis and implications for expected mode of transmission.External J Infect Dis. 1989;159(6):1126-8.
- DuPont HL, Hornick RB, Dawkins AT, Snyder MJ, Formal SB. The response of man to virulent Shigella flexneri 2a.External J Infect Dis. 1969;119(3):296-9.
- Beuchat LR, Ryu JH. Produce handling and processing practices. Emerg Infect Dis. 1997;3(4):459-65.
- Adams DA, Jajosky RA, Ajani U, Kriseman J, Sharp P, Onwen DH, Schley AW, Anderson WJ, Grigoryan A, Aranas AE, Wodajo MS, Abellera JP. Summary of notifiable diseases–United States, 2012. MMWR Morb Mortal Wkly Rep. 2014;61(53):1-121.
- Aragon TJ, Vugia DJ, Shallow S, Samuel MC, Reingold A, Angulo FJ, Bradford WZ. Case-control study of shigellosis in San Francisco: the role of sexual transmission and HIV infection.External Clin Infect Dis. 2007;44(3):327-34.
- Gaudreau C, Barkati S, Leduc JM, Pilon PA, Favreau J, Bekal S. Shigellaspp. with reduced azithromycin susceptibility, Quebec, Canada, 2012-2013. Emerg Infect Dis. 2014;20(5):854-6.
- Gaudreau C, Ratnayake R, Pilon PA, Gagnon S, Roger M, Levesque S. Ciprofloxacin-resistant Shigellasonnei among men who have sex with men, Canada, 2010. Emerg Infect Dis. 2011;17(9):1747-50.
- Panel on Opportunistic Infections in HIV-Infected Adults and Adolescents. Guidelines for the prevention and treatment of opportunistic infections in HIV-infected adults and adolescents: recommendations from the Centers for Disease Control and Prevention, the National Institutes of Health, and the HIV Medicine Association of the Infectious Diseases Society of America. Cdc-pdf[PDF – 408 pages]External. US Department of Health and Human Services, 2015.
- Okame M, Adachi E, Sato H, Shimizu S, Kikuchi T, Miyazaki N, Koga M, Nakamura H, Suzuki M, Oyaizu N, Fujii T, Iwamoto A, Koibuchi T. Shigella sonnei outbreak among men who have sex with men in Tokyo.External Jpn J Infect Dis. 2012;65(3):277-8.
- Heiman KE, Karlsson M, Grass J, Howie B, Kirkcaldy RD, Mahon B, Brooks JT, Bowen A. Notes from the field: Shigella with decreased susceptibility to azithromycin among men who have sex with men – United States, 2002-2013. MMWR Morb Mortal Wkly Rep. 2014;63(6):132-3.
- Watson JT, Jones RC, Fernandez J, Cortes C, Gerber SI, Kuo KJ, Price JS, Brooks JT, Jennings D, Fair M, Mintz E, Bowen A. Shigella flexneri serotype 3 infections among men who have sex with men–Chicago, Illinois, 2003-2004. Cdc-pdf[PDF – 24 pages] MMWR Morb Mortal Wkly Rep. 2005;54(33):820-2.
- Baker KS, Dallman TJ, Ashton PM, Day M, Hughes G, Crook PD, Gilbart VL, Zittermann S, Allen VG, Howden BP, Tomita T, Valcanis M, Harris SR, Connor TR, Sintchenko V, Howard P, Brown JD, Petty NK, Gouali M, Thanh DP, Keddy KH, Smith AM, Talukder KA, Faruque SM, Parkhill J, Baker S, Weill FX, Jenkins C,Thomson NR. Intercontinental dissemination of azithromycin-resistant shigellosis through sexual transmission: a cross-sectional study.External Lancet Infect Dis. 2015.
- Bowen A, Hurd J, Hoover C, Khachadourian Y, Traphagen E, Harvey E, Libby T, Ehlers S, Ongpin M, Norton JC, Bicknese A, Kimura A. Importation and domestic transmission of Shigella sonnei resistant to ciprofloxacin – United States, May 2014-February 2015. MMWR Morb Mortal Wkly Rep. 2015;64(12):318-20.
- Hoffmann C, Sahly H, Jessen A, Ingiliz P, Stellbrink HJ, Neifer S, Schewe K, Dupke S, Baumgarten A, Kuschel A, Krznaric I. High rates of quinolone-resistant strains of Shigella sonnei in HIV-infected MSM.External Infection. 2013;41(5):999-1003.
- Morgan O, Crook P, Cheasty T, Jiggle B, Giraudon I, Hughes H, Jones SM. Shigella sonnei outbreak among homosexual men, London. Emerg Infect Dis. 2006;12(9):1458-60.
- Nelson MR, Shanson DC, Hawkins D, Gazzard BG. Shigella in HIV infection. AIDS. 1991;5(8):1031-2.
- De Schrijver K, Bertrand S, Gutierrez Garitano I, Van den Branden D, Van Schaeren J. Outbreak of Shigella sonnei infections in the Orthodox Jewish community of Antwerp, Belgium, April to August 2008.External Euro Surveill. 2011;16(14).
- Garrett V, Bornschlegel K, Lange D, Reddy V, Kornstein L, Kornblum J, Agasan A, Hoekstra M, Layton M, Sobel J. A recurring outbreak of Shigella sonnei among traditionally observant Jewish children in New York City: the risks of daycare and household transmission.External Epidemiol Infect. 2006;134(6):1231-6.
- Sobel J, Cameron DN, Ismail J, Strockbine N, Williams M, Diaz PS, Westley B, Rittmann M, DiCristina J, Ragazzoni H, Tauxe RV, Mintz ED. A prolonged outbreak of Shigella sonnei infections in traditionally observant Jewish communities in North America caused by a molecularly distinct bacterial subtypeExternal. J Infect Dis. 1998;177(5):1405-9.
- Kantele A. As far as travelers’ risk of acquiring resistant intestinal microbes is considered, no antibiotics (absorbable or nonabsorbable) are safe.External Clin Infect Dis. 2015.
- O’Donnell AT, Vieira AR, Huang JY, Whichard J, Cole D, Karp BE. Quinolone-resistant Salmonella enterica serotype Enteritidis infections associated with international travelExternal. Clin Infect Dis. 2014;59(9):e139-41.
- Pons MJ, Gomes C, Martinez-Puchol S, Ruiz L, Mensa L, Vila J, Gascon J, Ruiz J. Antimicrobial resistance in Shigella spp. causing traveller’s diarrhoea (1995-2010): a retrospective analysis.External Travel Med Infect Dis. 2013;11(5):315-9.
- De Lappe N, O’Connor J, Garvey P, McKeown P, Cormican M. Ciprofloxacin-Resistant Shigella sonnei Associated with Travel to India. Emerg Infect Dis. 2015;21(5):894-6.
- CDC. National Antimicrobial Resistance Monitoring System: Enteric bacteria 2012. Cdc-pdf[PDF – 88 pages] 2013.
- CDC. Antibiotic resistance threats in the United States, 2013. Cdc-pdf[PDF – 114 pages] 2013.