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Chagas Disease: What U.S. Clinicians Need to Know

Antitrypanosomal Drug Regimens

Drug Age group Dosage and duration
Benznidazole 2–12 years of age* 5–8 mg/kg per day orally in 2 divided doses for 60 days
Lampit® (nifurtimox)  Birth to younger than 18 years of age, weighing at least 2.5 kg** Body weight greater than or equal to 40 kg:
8–10 mg/kg per day orally in 3 divided doses for 60 days
Body weight less than 40 kg:
10–20 mg/kg per day orally in 3 divided doses for 60 days
* Benznidazole is FDA approved for the treatment of Chagas disease (American trypanosomiasis) caused by Trypanosoma cruzi in pediatric patients 2–12 years of age. Use of benznidazole to treat a patient outside of the FDA-approved age range of 2–12 years is based on clinical diagnosis and decision by the treating physician under practice of medicine.

** Lampit® (nifurtimox) is FDA approved for the treatment of Chagas disease (American trypanosomiasis) caused by Trypanosoma cruzi in pediatric patients from birth to younger than 18 years (weighing at least 2.5 kg). Use of nifurtimox to treat a patient outside of the FDA-approved age range of birth to younger than 18 years is based on clinical diagnosis and decision by the treating physician under practice of medicine.
Version: 1.1 Pub: Oct 2010 Rev: Aug 2012

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