CAS No. 127-18-4
Tetrachloroethylene (Cl₂C=CCl₂) is a colorless liquid with a mild, chloroform-like odor. Exposure to tetrachloroethylene may cause irritation eyes, skin, nose, throat, and respiratory system. It may also cause liver damage and is a potential occupational carcinogen. Workers may be harmed from exposure to tetrachloroethylene. The level of exposure depends upon the dose, duration, and work being done.
Tetrachloroethylene is used in many industries. It’s used to dry clean fabrics, manufacture other chemicals, and degreasing metal parts. Some examples of workers at risk of being exposed to tetrachloroethylene include the following:
- Workers in dry cleaning industries
- Workers who use it to degrease metals
- Workers in industries who use it to make other chemicals
NIOSH recommends that employers use Hierarchy of Controls to prevent injuries. If you work in an industry that uses tetrachloroethylene, please read chemical labels and the accompanying Safety Data Sheets for hazard information. Visit NIOSH’s page on Managing Chemical Safety in the Workplace to learn more about controlling chemical workplace exposures.
The following resources provide information about occupational exposure to tetrachloroethylene. Useful search terms for tetrachloroethylene include “perchlorethylene,” “perchloroethylene,” “perk,” and “tetrachlorethylene.”
The NIOSH Pocket Guide to Chemical Hazards (NPG) helps workers, employers, and occupational health professionals recognize and control workplace chemical hazards.
The NIOSH Manual of Analytical Methods (NMAM) is a collection of methods for sampling and analysis of contaminants in workplace air, and in the blood and urine of workers who are occupationally exposed.
Related NIOSH Resources
- NIOSHTIC-2 search results on tetrachloroethylene—NIOSHTIC-2 is a searchable database of worker safety and health publications, documents, grant reports, and journal articles supported in whole or in part by NIOSH.
- Immediately Dangerous to Life or Health (IDLH) Value Profile: Hydrocarbons, Halogenated (No. 1003)pdf icon—The IDLH documents the criteria and information sources that have been used by NIOSH to determine immediately dangerous to life or health concentrations.
- Immediately Dangerous to Life or Health (IDLH) Value Profile: Perchloroethylene (port GC) in exhaled breath and air (No. 3704pdf icon)—The IDLH documents the criteria and information sources that have been used by NIOSH to determine immediately dangerous to life or health concentrations.
- Dry Cleaners: Organic Solvents—The NIOSH worker Notification Program notifies workers and other stakeholders about the findings of these research studies.
- Dry Cleaners: Organic Solvents/Perchloroethylene—The NIOSH worker Notification Program notifies workers and other stakeholders about the findings of these research studies.
- NIOSH Occupational Safety and Health Guideline for tetrachloroethylenepdf icon—This guideline helps stakeholders conduct effective occupational safety and health programs.
- NIOSH Criteria Documents: Criteria for a Recommended Standard: Occupational Exposure to Tetrachloroethylene, DHHS (NIOSH) Publication No. 76-185—Presents a standard to prevent the adverse effects of exposure to tetrachloroethylene over a working lifetime.
- Current Intelligence Bulletin No. 20: Tetrachloroethylene, DHHS (NIOSH) Publication No. 78-111—This Bulletin shares the findings of the NCI study, other pertinent data, their implications for occupational health, and precautions for handling tetrachloroethylene.
- NIOSH Safety and Health Topic: Drycleaning —Provides a collection of resources focused upon identifying and controlling the exposure of workers to tetrachloroethylene (perchloroethylene), as well as other hazards
- ATSDR Public Health Statement: Tetrachloroethylene
- ATSDR–ToxFAQs: Tetrachloroethylene
- ATSDR Case Studies in Environmental Medicine: Tetrachloroethylene
- ATSDR Toxicological Profile for Tetrachloroethylene
- EPA Chemistry Dashboardexternal icon
- EPA Acute Exposure Guideline Levels (AEGLs): Tetrachloroethyleneexternal icon
- EPA Air Toxics: Tetrachloroethyleneexternal icon
- EPA Consumer Fact Sheet Ground and Drinking Water: Tetrachloroethyleneexternal icon
- EPA OPPT Chemical Fact Sheet: Perchloroethylenetxt iconexternal icon
- EPA Integrated Risk Information System IRIS: Tetrachloroethyleneexternal icon
- NLM Hazardous Substance Data Bank: Tetrachloroethyleneexternal icon
- NLM Haz-Map: Tetrachloroethyleneexternal icon
- NLM Household Products Database: Tetrachloroethyleneexternal icon
- OSHA Hazard Communicationexternal icon
- OSHA Safety and Health Topics: Tetrachloroethyleneexternal icon
- OSHA Chemical Sampling Information: Tetrachloroethyleneexternal icon
- New Jersey Hazardous Substance Fact Sheets: Tetrachloroethylenepdf iconexternal icon
- Canadian Centre for Occupational Health and Safety: Tetrachloroethyleneexternal icon
- European Chemicals Agency (ECHA): Tetrachloroethylene external icon
- Gestis Substance Databaseexternal icon
- ILO International Chemical Safety Card: Tetrachloroethyleneexternal icon
- IARC Monograph (Vol 106): Tetrachloroethylenepdf iconexternal icon
- IARC Monograph (Vol. 63): Tetrachloroethyleneexternal icon
- IPCS INCHEM: Tetrachloroethyleneexternal icon
- NTP Report on Carcinogens: Tetrachloroethyleneexternal icon
- OECD Global Portal to Information on Chemical Substancesexternal icon
- WHO CICAD 68: Tetrachloroethylenepdf iconexternal icon
- WHO Environmental Health Criteria 31: Tetrachloroethyleneexternal icon
- WHO HSG No. 10: Tetrachloroethyleneexternal icon