Finite Dose Skin Permeation Calculator

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Finite Dose Skin Permeation Calculator

Description

Many models have been developed to calculate the steady-state permeability from an aqueous solution of infinite volume. These do not, however, correspond to a typical occupational exposure scenario. But this calculator estimates fluxes, skin concentrations, and amounts absorbed from any size dose applied to partially or fully hydrated skin. The calculations are based on the model described in the references below.

Various inputs are required: molecular weight (MW), the base-10 logarithm of the octanol-water partition coefficient (logKow), melting point and boiling point of the compound of interest. These and other optional properties may be obtained free from EPI Suite™ or other estimation software packages or databases. Further instructions can be found on the information tab.

A downloadable version of the Finite Dose Skin Permeation Calculator is now available. Please click here to download an executable file to your computer.

Clicking on the .jar file will open the calculator on your computer.

Inquiries

For general help, contact Ray Wells (ozw0@cdc.gov).

Acknowledgments

The Finite Dose Skin Permeation Calculator was developed by Adam Fedorowicz, Matthew Miller, Gerald Kasting and Fred Frasch and with partial financial support from NIOSH/CDC grant R01 OH007529.

Disclaimer

Neither NIOSH nor the University of Cincinnati warrants or assumes any legal liability or responsibility for the accuracy, completeness, or usefulness of the information generated by the Finite Dose Skin Permeation Calculator. You should not rely on any such information for any assessment of the risks of any specific experiment, procedure or process that you wish to carry out; you should always carry out your own risk assessment for such purposes. The information generated by the Finite Dose Skin Permeation Calculator may not be correct or appropriate for local regulations, legal codes, practices or policies. The information may be out of date. Neither NIOSH nor the University of Cincinnati takes responsibility for any injury, loss, or damage caused in any manner whatsoever by the use of the information generated by the Finite Dose Skin Permeation Calculator.

References

  1. Kasting, G. B. and M. A. Miller (2006). “Kinetics of finite dose absorption through skin 2. Volatile compounds.” Journal of Pharmaceutical Sciences 95(2): 268-280.
  2. Miller, M. A. and G. B. Kasting (2010). “Toward a Better Understanding of Pesticide Dermal Absorption: Diffusion Model Analysis of Parathion Absorption in Vitro and in Vivo.” Journal of Toxicology and Environmental Health 73(4): 284 – 300.
  3. Kasting, G. B., M. A. Miller, et al. (2008). “A Spreadsheet-Based Method for Estimating the Skin Disposition of Volatile Compounds: Application to N,N-Diethyl-m-Toluamide (DEET).” Journal of Occupational and Environmental Hygiene 5(10): 633-644.
  4. Wang, T.-F., G. B. Kasting, et al. (2007). “A multi phase microscopic model for stratum corneum permeability. II. Estimation of physicochemical parameters and application to a large permeability database.” Journal of Pharmaceutical Sciences 96(11): 3024-3051.

Keywords

skin permeation, skin penetration, dermal absorption, percutaneous absorption, transdermal drug transport, stratum corneum, viable epidermis, dermis, in silico, mathematical model, skin concentrations, dermal risk assessment

Page last reviewed: July 2, 2013