CAS No. 95-53-4

ortho-Toluidine (CH3C6H4NH2) is a colorless to pale-yellow liquid. It is a toxic substance harmful to the eyes, skin, and when swallowed or inhaled. ortho-Toluidine can cause cancer. Workers may be harmed from exposure to ortho-toluidine.  The level of exposure depends upon the dose, duration, and work being done.

ortho-Toluidine is used in many industries. It is used in some hair dyes, weed and pest killers, rubber, and in some laboratory processes. Some examples of workers at risk of being exposed to ortho-toluidine include the following:

  • Workers who are exposed to certain hair dyes
  • Factory workers involved in rubber manufacture
  • Employees who are exposed to cigarette smoke
  • Laboratory workers who stain tissues or analyze glucose

NIOSH recommends that employers use Hierarchy of Controls to prevent injuries. If you work in an industry that uses ortho-toluidine, please read chemical labels and the accompanying Safety Data Sheets for hazard information. Visit NIOSH’s page on Managing Chemical Safety in the Workplace to learn more about controlling chemical workplace exposures.

The following resources provide information about occupational exposure to ortho-toluidine. Useful search terms for ortho-toluidine include “2-aminotoluene,” “o-aminotoluene,” “1-methyl-2-aminobenzene,” “2-methylaniline,” “o-methylaniline,” “o-toluidine,” and “o-tolylamine.”

NIOSH Chemical Resources

If you work with this chemical, it is important to limit your exposure as much as possible.

Learn more about o-toluidine and how to keep workers safe.

Logo of NIOSH Pocket Guide

The NIOSH Pocket Guide to Chemical Hazards (NPG) helps workers, employers, and occupational health professionals recognize and control workplace chemical hazards.

Logo of Manual of Analytical Methods.

The NIOSH Manual of Analytical Methods (NMAM) is a collection of methods for sampling and analysis of contaminants in workplace air, and in the blood and urine of workers who are occupationally exposed.

Logo of Health Hazard Evaluations consisting of three letters: HHE

The Health Hazard Evaluation Program (HHE) conducts onsite investigations of possible worker exposure to chemicals. Search the HHE database for more information on ortho-toluidine.

Related NIOSH Resources

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International Resources

Page last reviewed: June 6, 2014 (archived document)