CAS No. 95-53-4

ortho-Toluidine (CH3C6H4NH2) is a colorless to pale-yellow liquid. It is a toxic substance harmful to the eyes, skin, and when swallowed or inhaled. ortho-Toluidine can cause cancer. Workers may be harmed from exposure to ortho-toluidine.  The level of exposure depends upon the dose, duration, and work being done.

ortho-Toluidine is used in many industries. It is used in some hair dyes, weed and pest killers, rubber, and in some laboratory processes. Some examples of workers at risk of being exposed to ortho-toluidine include the following:

  • Workers who are exposed to certain hair dyes
  • Factory workers involved in rubber manufacture
  • Employees who are exposed to cigarette smoke
  • Laboratory workers who stain tissues or analyze glucose

NIOSH recommends that employers use Hierarchy of Controls to prevent injuries. If you work in an industry that uses ortho-toluidine, please read chemical labels and the accompanying Safety Data Sheets for hazard information. Visit NIOSH’s page on Managing Chemical Safety in the Workplace to learn more about controlling chemical workplace exposures.

The following resources provide information about occupational exposure to ortho-toluidine. Useful search terms for ortho-toluidine include “2-aminotoluene,” “o-aminotoluene,” “1-methyl-2-aminobenzene,” “2-methylaniline,” “o-methylaniline,” “o-toluidine,” and “o-tolylamine.”

About Ortho-toluidine
Information for Industrial Workers
Information for Employers of Industrial Workers
Related Resources


Related NIOSH Resources

Selected Publications

Related Resources

International Resources