Cardiovascular Disease and Occupational Factors
Laboratory-Based Work, Occupational Factors, and CVD
Using laboratory-based methods, NIOSH investigators are assessing sub-clinical cardiovascular responses to a variety of occupational exposures including nanoparticles. These sub-clinical responses may potentially include cellular effects, effects within tissues such as small blood vessels, and also overall physiologic response such as changes in heart rate and blood pressure 1, 2. The work of these researchers is essential in furthering our knowledge of occupational factors and cardiovascular disease, with the aim of earlier detection and prevention before damage progresses. For more information concerning the NIOSH Nanotechnology Research Center see their website.
- Kan H, Wu Z, Lin Y, Chen TB, Cumpston JL, Kashon ML, Leonard SS, Munson AE, Castranova V . The role of nodose ganglia in the regulation of cardiovascular function following pulmonary exposure to ultrafine titanium dioxide. Nanotoxicology 8(4):447-454.
- Aragon M, Erdely A, Bishop L, Salmen R, Weaver J, Liu J, Hall P, Eye T, Kodali V, Zeidler-Erdely P, Stafflinger JE, Ottens AK, Campen MJ . MMP-9-Dependent Serum-Borne Bioactivity Caused by Multiwalled Carbon Nanotube Exposure Induces Vascular Dysfunction Via the CD36 Scavenger Receptor. Toxicol Sci 150(2):488-498.