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Immediately Dangerous to Life or Health Profiles

NIOSH Scientific Information Quality – Peer Review Agenda

Final Document(s)

Related Materials

Required Elements for Initial Public Posting

Subject: NIOSH Immediately Dangerous to Life or Health value for Acetonitrile, Chloroacetonitrile, Methacrylonitrile, and Nitrogen Dioxide.

Purpose: The purpose of these technical reports is to document the scientific basis of the NIOSH immediately dangerous to life or health (IDLH) value for acetonitrile, chloroacetonitrile, methacrylonitrile, and nitrogen dioxide. The toxicologic data and risk assessment approach used to derive the IDLH values are summarized to ensure transparency and scientific credibility. The IDLH values are intended to protect workers from short-term high-risk exposure conditions. They are based on a 30-minute exposure duration and have traditionally served as a key component of the decision logic for the selection of respiratory protection devices.

Timing of Review: Public review May 5, 2017 – July 5, 2017.

Primary Disciplines or Expertise Needed for Review: Toxicology, risk assessment, industrial hygiene, occupational medicine

Type of Review: Individual

Number of Reviewers: 4

Reviewers Selected by: NIOSH

Public Nominations Requested for Reviewers: No

Opportunities for the Public to Comment: Yes

Peer Reviewers Provided with Public Comments Before Their Review: No

Peer Reviewers

Michael S. Bisesi, Ph.D., R.E.H.S., C.I.H.
Senior Associate Dean for Academic Affairs
Director, Center for Public Health Practice, College of Public Health
Ohio State University

Randall Keller, Ph.D., C.I.H., C.S.P., D.A.B.T.
Professor; Occupational Safety and Health Department
Jesse D. Jones College of Science, Engineering, and Technology
Murray State University

Barry J. Marcel, Ph.D.
Environmental Health Consultant
United States Air Force, Wright-Patterson Air Force Base

Richard B. Schlesinger, Ph.D., Fellow A.T.S.
Senior Associate Dean for Academic Affairs and Research and Professor of Biology
Dyson College of Arts and Sciences
Pace University, New York, NY

Charge to Peer Reviewers

The National Institute for Occupational Safety and Health (NIOSH) of the Centers for Disease Control and Prevention (CDC) is conducting a peer and public review of the draft Immediately Dangerous to Life or Health (IDLH) values and support technical documents, entitled IDLH Values Profiles. The draft documents are based on the process outlined in the NIOSH Current Intelligence Bulletin 66 – Derivation of Immediately Dangerous to Life or Health (IDLH) Values.

Each IDLH Value Profile document provides a detailed summary of the health hazards of acute exposures to high airborne concentrations and the rationale for the proposed IDLH value with the chemical(s) of interest.

To facilitate the review of these documents, NIOSH requests that the following questions be taken into consideration:

  1. Does this document clearly outline the health hazards associated with acute (or short-term) exposures to the chemical? If not, what specific information is missing from the document?
  2. Is the rationale and logic behind the derivation of an IDLH value for a specific chemical clearly explained? If not, what specific information is needed to clarify the basis of the IDLH value?
  3. Are the conclusions supported by the data?
  4. Are the tables clear and appropriate?
  5. Is the document organized appropriately? If not, what improvements are needed?
  6. Are you aware of any scientific data reported in governmental publications, databases, peer-reviewed journals, or other sources that should be included within this document?
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