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workers, building, architect

NORA Manufacturing Sector Strategic Goals

9277312 - 1- bromopropane: Current Intelligence Bulletin

Start Date: 10/1/2000
End Date: 9/30/2011

Principal Investigator (PI)
Name: Gary Dotson
Phone: 513-533-8540
Organization: NIOSH
Sub-Unit: EID
Funded By: NIOSH

Primary Goal Addressed

Secondary Goal Addressed


Attributed to Manufacturing


Project Description

Short Summary

1-bromopropane is a solvent used in a variety of industrial applications in adhesives in foam furniture manufacture and in degreasing processes. 1-Bromopropane is often contaminated with 2-bromopropane, which has greater toxicity. Toxic effects from exposure may occur as a result of inhalation or absorption through the skin. Based on published scientific research and human case reports, these solvents appear to be reproductive hazards and related to adverse effects of the blood and to neurological disorders.


N-propyl bromide is being used increasingly as a solvent in the United States (U.S.), especially as a substitute for methylene chloride. It is currently being reviewed by the U.S. Environmental Protection Agency Significant New Alternatives Policy (SNAP) Program. I-propyl bromide is not used in the US but is a common contaminant of n-propyl bromide. Both compounds have been associated with reproductive and neurological toxicity and are under study by the National Toxicology Program. This document will overview toxicity data and provide important information on worker protection.


The objective of this project is to protect workers from hazardous exposure to bromopropane by developing a Current Intelligent Bulletin that will summarize the health risks from exposure to 1- and 2-bromopropane. A recommended exposure limit for 1-bromopropane will be developed and adequacy of data for developing a recommended limit for 2-bromopropane will be reviewed. The document will also describe the extent and characteristics of occupational exposure, and provide strategies for preventing exposure at work, such as engineering controls and personal protective equipment.

Mission Relevance

1-Bromopropane (1-BP) is a solvent which is being used increasingly as a substitute for commonly used, chlorinated solvents such as methylene chloride. 1-BP is often contaminated with 2-bromopropane (2-BP), a known reproductive toxin. Strong animal data suggests that 1-BP may also be a reproductive toxin. Workers are currently exposed to 1-BP in the foam furniture manufacturing industry, where the 1-BP is used as an adhesive solvent, and in the electronic industry, where 1-BP is used as a degreasing agent. Other government agencies have nominated both compounds for further study by the National Toxicology Program. Two chemical companies have current occupational exposure limits (OELs) for 1-BP of 10 and 25 ppm. There is no OEL either for 1-BP or 2-BP by authoritative standards setting organizations in the U.S. The Korean Institute of Health and Safety has issued its first occupational exposure limit for 2-BP of 1 ppm. The CIB produced by this project will make recommendations concerning the control of occupational exposures through the use of engineering controls, appropriate personal protective devices, and work practices. This project contributes to the following goals:

Sector Program

Manufacturing: This goal addresses Strategic Goal 8: Reduce the incidence of injuries, illnesses, and fatalities within small businesses (less than 100 employees) and specific subsectors within the manufacturing sector.

Cross Sector Health Outcome Programs

Cancer, Reproductive, and Cardiovascular Diseases


Strategic Goal 2: Reduce mortality from work-related cancer through early interventions.

Activity/Output Goal 2.1.2. (09PPCRCAOG2.1.2); Conduct studies of highpriority exposures to identify and quantify risk of adverse reproductive health associated with workplace exposures.


Strategic Goal 4: Reduce the incidence and mortality of work-related cardiovascular disease.

Other Cross-Sector Programs

Authoritative Recommendation Development


Strategic Goal 1: Reduce and prevent occupational injuries, illnesses, and fatalities by supporting NORA sector and cross-sector programs in the development of authoritative recommendations.

Intermediate Goal 1:.Identify goals or objectives in each of the NORA sectors that can be fully or partially addressed through the development of an Authoritative Recommendations document.