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Comparison of methods for analyzing left-censored occupational exposure data.

Huynh T; Ramachandran G; Banerjee S; Monteiro J; Stenzel M; Sandler DP; Engel LS; Kwok RK; Blair A; Stewart PA

Ann Occup Hyg 2014 Nov; 58(9):1126-1142

https://doi.org/10.1093/annhyg/meu067

20055689

The National Institute for Environmental Health Sciences (NIEHS) is conducting an epidemiologic study (GuLF STUDY) to investigate the health of the workers and volunteers who participated from April to December of 2010 in the response and cleanup of the oil release after the Deepwater Horizon explosion in the Gulf of Mexico. The exposure assessment component of the study involves analyzing thousands of personal monitoring measurements that were collected during this effort. A substantial portion of these data has values reported by the analytic laboratories to be below the limits of detection (LOD). A simulation study was conducted to evaluate three established methods for analyzing data with censored observations to estimate the arithmetic mean (AM), geometric mean (GM), geometric standard deviation (GSD), and the 95th percentile (X0.95) of the exposure distribution: the maximum likelihood (ML) estimation, the ß-substitution, and the Kaplan-Meier (K-M) methods. Each method was challenged with computer-generated exposure datasets drawn from lognormal and mixed lognormal distributions with sample sizes (N) varying from 5 to 100, GSDs ranging from 2 to 5, and censoring levels ranging from 10 to 90%, with single and multiple LODs. Using relative bias and relative root mean squared error (rMSE) as the evaluation metrics, the ß-substitution method generally performed as well or better than the ML and K-M methods in most simulated lognormal and mixed lognormal distribution conditions. The ML method was suitable for large sample sizes (N>/= 30) up to 80% censoring for lognormal distributions with small variability (GSD = 2-3). The K-M method generally provided accurate estimates of the AM when the censoring was <50% for lognormal and mixed distributions. The accuracy and precision of all methods decreased under high variability (GSD = 4 and 5) and small to moderate sample sizes (N < 20) but the ß-substitution was still the best of the three methods. When using the ML method, practitioners are cautioned to be aware of different ways of estimating the AM as they could lead to biased interpretation. A limitation of the ß-substitution method is the absence of a confidence interval for the estimate. More research is needed to develop methods that could improve the estimation accuracy for small sample sizes and high percent censored data and also provide uncertainty intervals.

Statistical analysis; Exposure assessment; Models; Mathematical models; Oil spills; Environmental pollution; Author Keywords: exposure assessment; left-censored data; the GuLF STUDY

Gurumurthy Ramachandran, University of Minnesota, Division of Environmental Health Sciences, School of Public Health, Minneapolis, MN 55455, USA

AOHYA3

20141101

Journal Article

ramac002@umn.edu

Grant

2015

Grant-Number-R01-OH-010093

9

0003-4878

Annals of Occupational Hygiene

CA; MN; NC; VA; MD

University of California, Los Angeles