Evidence from. animal and human studies suggest that components of JP8 jet fuel can disrupt the neuroendocrine axes that control or impact the reproductive and immunologic systems. Human studies have demonstrated reduced secretion of luteinizing hormone (LH) associated with toluene and JP8 exposure. LH is critical for reproductive performance, but also effects immunologic functions by increasing interleukins involved in natural killer cell activation and B-cell differentiation. Adrenocorticopic hormone, follicle stimulating hormone (FSH), prolactin, corticosterone, testosterone, and estradiol also regulate immune function and are affected by compounds in fuels and exhaust JP8 represents the most common chemical exposure among members of the Armed Forces. The specific objective of this aspect of the study is to determine endocrine levels in the peripheral blood and Whether these endocrine concentrations are associated with JP8 exposure or other work conditions. Information gathered in this study would help the National Institute for Occupational Safety and Health (NIOSH) establish recommended exposure limits for military and civilian aviation.
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