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Carbon nanotube and asbestos exposures induce overlapping but distinct profiles of lung pathology in non-swiss albino CF-1 mice.

Authors
Frank-EA; Carreira-VS; Birch-ME; Yadav-JS
Source
Toxicol Pathol 2016 Feb; 44(2):211-225
NIOSHTIC No.
20047759
Abstract
Carbon nanotubes (CNTs) are emerging as important occupational and environmental toxicants owing to their increasing prevalence and potential to be inhaled as airborne particles. CNTs are a concern because of their similarities to asbestos, which include fibrous morphology, high aspect ratio, and biopersistence. Limitations in research models have made it difficult to experimentally ascertain the risk of CNT exposures to humans and whether these may lead to lung diseases classically associated with asbestos, such as mesothelioma and fibrosis. In this study, we sought to comprehensively compare profiles of lung pathology in mice following repeated exposures to multiwall CNTs or crocidolite asbestos (CA). We show that both exposures resulted in granulomatous inflammation and increased interstitial collagen; CA exposures caused predominantly bronchoalveolar hyperplasia, whereas CNT exposures caused alveolar hyperplasia of type II pneumocytes (T2Ps). T2Ps isolated from CNT-exposed lungs were found to have upregulated proinflammatory genes, including interleukin 1ß (IL-1ß), in contrast to those from CA exposed. Immunostaining in tissue showed that while both toxicants increased IL-1ß protein expression in lung cells, T2P-specific IL-1ß increases were greater following CNT exposure. These results suggest related but distinct mechanisms of action by CNTs versus asbestos which may lead to different outcomes in the 2 exposure types.
Keywords
Carbon nanotubes; Toxins; Airborne particles; Particulates; Asbestos; Fibrous bodies; Models; Exposure levels; Risk factors; Lung; Lung disease; Mesothelioma; Fibrosis; Pathology; Animals; Laboratory animals; Genes; Author Keywords: carbon nanotubes; crocidolite asbestos; fiber toxicology; comparative pathology; lung; mouse
Contact
Jagjit S. Yadav, University of Cincinnati College of Medicine, Kettering Laboratory Complex, 160 Panzeca Way, Cincinnati, OH 45267
CODEN
TOPADD
CAS No.
1332-21-4
Publication Date
20160201
Document Type
Journal Article
Email Address
jagjit.yadav@uc.edu
Funding Type
Grant
Fiscal Year
2016
Identifying No.
Grant-Number-T42-OH-008432
Issue of Publication
2
ISSN
0192-6233
NIOSH Division
DART
Priority Area
Manufacturing
Source Name
Toxicologic Pathology
State
OH
Performing Organization
University of Cincinnati
Page last reviewed: April 12, 2019
Content source: National Institute for Occupational Safety and Health Education and Information Division