NIOSHTIC-2 Publications Search

Antiviral drugs.

Authors
Othumpangat S; Noti JD; Ray SD
Source
Side effects of drugs annual: a worldwide yearly survey of new data in adverse drug reactions, first edition. Ray SD, Gray JP, Kiersma ME, Dukes MNG, eds. Waltham, MA: Elsevier, 2015 Nov; 37:329-348
NIOSHTIC No.
20047032
Abstract
Topical cidofovir treatment in herpes simples virus infections resulted in irreversible acute kidney injury. A 58-year-old man underwent a matched unrelated donor (MUD) stem cell transplant for secondary myelodysplastic syndrome. His conditioning regimen consisted of busulfan, fludarabine, and antithymocyte globulin. The patient received oral valganciclovir during the peritransplantation phase at a dose of 900 mg twice daily for CMV prophylaxis, and prophylactic valacyclovir was initiated on day 1. The patient was readmitted within 2 weeks of his initial hospital discharge with neutropenic fever, worsening mucositis, and acute cutaneous graft-versushost disease (GVHD). The patient was treated with intravenous (IV) acyclovir at 5 mg/kg followed by antiviral therapy containing 5% cidofovir administered as oral gel.
Keywords
Drugs; Viral-diseases; Viral-infections; Preventive-medicine; Infectious-diseases; Infection-control; Treatment; Kidney damage; Stem cells; Surgery; Author Keywords: Adefovir; Adverse reactions; Amprenavir; Antiretroviral drugs; Atazanavir; Boceprevir; Chemokine receptor CCR5 antagonists; Cidofovir; Cytomegalovirus; Darunavir; Didanosine; Dolutegravir; Efavirenz; Emtricitabine; Enfuvirtide; Etravirine; Famciclovir; Fosamprenavir; Foscarnet; Ganciclovir; Hepatitis viruses; Herpesviruses; HIV; Imiquimod; Indinavir; Influenza viruses; Inhibitors of HIV fusion; Integrase inhibitors; Ion channel inhibitors; Lamivudine; Lopinavir; Maraviroc; Nelfinavir; Neuraminidase inhibitors; Nevirapine; Non-nucleoside reverse transcriptase inhibitors; Nucleoside analogue reverse transcriptase inhibitors; Nucleotide analogue reverse transcriptase inhibitor; Oseltamivir; Protease inhibitors; Raltegravir; Ribavirin; Rilpivirine; Ritonavir; Simeprevir; Sofosbuvir; Stavudine; Telaprevir; Tenofovir; Tipranavir; Valaciclovir; Valganciclovir
Contact
Sreekumar Othumpangat, Allergy and Clinical Immunology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Road, Morgantown, WV 26505
CODEN
SEDAD8
Publication Date
20151113
Document Type
Chapter
Email Address
seo8@cdc.gov
Editors
Ray SD; Gray JP; Kiersma ME; Dukes MNG
Fiscal Year
2016
ISBN No.
9780444635259
ISSN
0378-6080
NIOSH Division
HELD
Priority Area
Healthcare and Social Assistance
Source Name
Side effects of drugs annual: a worldwide yearly survey of new data in adverse drug reactions, first edition
State
MA; WV
Page last reviewed: November 6, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division