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Antiviral drugs.

Othumpangat S; Noti JD; Ray SD

Side effects of drugs annual: a worldwide yearly survey of new data in adverse drug reactions, first edition. Ray SD, Gray JP, Kiersma ME, Dukes MNG, eds. Waltham, MA: Elsevier, 2015 Nov; 37:329-348

https://doi.org/10.1016/bs.seda.2015.05.002

20047032

Topical cidofovir treatment in herpes simples virus infections resulted in irreversible acute kidney injury. A 58-year-old man underwent a matched unrelated donor (MUD) stem cell transplant for secondary myelodysplastic syndrome. His conditioning regimen consisted of busulfan, fludarabine, and antithymocyte globulin. The patient received oral valganciclovir during the peritransplantation phase at a dose of 900 mg twice daily for CMV prophylaxis, and prophylactic valacyclovir was initiated on day 1. The patient was readmitted within 2 weeks of his initial hospital discharge with neutropenic fever, worsening mucositis, and acute cutaneous graft-versushost disease (GVHD). The patient was treated with intravenous (IV) acyclovir at 5 mg/kg followed by antiviral therapy containing 5% cidofovir administered as oral gel.

Drugs; Viral-diseases; Viral-infections; Preventive-medicine; Infectious-diseases; Infection-control; Treatment; Kidney damage; Stem cells; Surgery; Author Keywords: Adefovir; Adverse reactions; Amprenavir; Antiretroviral drugs; Atazanavir; Boceprevir; Chemokine receptor CCR5 antagonists; Cidofovir; Cytomegalovirus; Darunavir; Didanosine; Dolutegravir; Efavirenz; Emtricitabine; Enfuvirtide; Etravirine; Famciclovir; Fosamprenavir; Foscarnet; Ganciclovir; Hepatitis viruses; Herpesviruses; HIV; Imiquimod; Indinavir; Influenza viruses; Inhibitors of HIV fusion; Integrase inhibitors; Ion channel inhibitors; Lamivudine; Lopinavir; Maraviroc; Nelfinavir; Neuraminidase inhibitors; Nevirapine; Non-nucleoside reverse transcriptase inhibitors; Nucleoside analogue reverse transcriptase inhibitors; Nucleotide analogue reverse transcriptase inhibitor; Oseltamivir; Protease inhibitors; Raltegravir; Ribavirin; Rilpivirine; Ritonavir; Simeprevir; Sofosbuvir; Stavudine; Telaprevir; Tenofovir; Tipranavir; Valaciclovir; Valganciclovir

Sreekumar Othumpangat, Allergy and Clinical Immunology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Road, Morgantown, WV 26505

SEDAD8

20151113

Chapter

seo8@cdc.gov

Ray SD; Gray JP; Kiersma ME; Dukes MNG

2016

9780444635259

0378-6080

HELD

Healthcare and Social Assistance

Side effects of drugs annual: a worldwide yearly survey of new data in adverse drug reactions, first edition

MA; WV