Pharmacists, nurses, and other health care personnel who handle antineoplastic (chemotherapy) drugs require appropriately tested gloves that protect them from dermal exposure, but there is confusion about which gloves provide adequate protection. The American society for Testing and Materials (ASTM) currently has two standards for testing the permeation of glove materials by chemicals: ASTM F739-99a (F739), which is the Standard Test Method for Resistance of Protective Clothing Materials to Permeation by Liquids or Gases Under Conditions of continuous Contact, and ASTM D6978-05 (D6978), which is the Standard Practice for Assessment of Resistance of Medical Gloves to Permeation by Chemotherapy Drugs. Because of the highly toxic nature of chemotherapy agents, the National Institute for Occupational Safety and Health (NIOSH), the American Society of Heath-system Pharmacists (ASHP), the Oncology Nursing Society (ONS), and the United States Pharmacopeial Convention (USP) state that health care workers who handle antineoplastic and other hazardous drugs (HDs) should wear gloves that have been tested for permeation by the more robust D6978 standard rather than the standard used for other chemicals-F739.
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