Associations of work hours, job strain, and occupation with endothelial function: the Multi-Ethnic Study of Atherosclerosis (MESA).
Charles-LE; Fekedulegn-D; Landsbergis-P; Burchfiel-CM; Baron-S; Kaufman-JD; Stukovsky-KH; Fujishiro-K; Foy-CG; Andrew-ME; Diez Roux-AV
J Occup Environ Med 2014 Nov; 56(11):1153-1160
Objective: To investigate associations of work hours, job control, job demands, job strain, and occupational category with brachial artery flow-mediated dilation (FMD) in 1499 Multi-Ethnic Study of Atherosclerosis participants. Methods: Flow-mediated dilation was obtained using high-resolution ultrasound. Mean values of FMD were examined across categories of occupation, work hours, and the other exposures using regression analyses. Results: Occupational category was significantly associated with FMD overall, with blue-collar workers showing the lowest mean values-management/professional = 4.97 +/- 0.22%; sales/office = 5.19 +/- 0.28%; services = 4.73 +/- 0.29%; and blue-collar workers = 4.01 +/- 0.26% (adjusted P < 0.001). There was evidence of effect modification by sex (interaction P = 0.031)-significant associations were observed among women (adjusted P = 0.002) and nearly significant results among men (adjusted P = 0.087). Other exposures were not significantly associated with FMD. Conclusions: Differences in endothelial function may account for some of the variation in cardiovascular disease across occupational groups.
Cardiovascular-disease; Cardiovascular-system-disease; Cardiovascular-system-disorders; Cardiovascular-function; Work-intervals; Humans; Men; Women; Epidemiology; Statistical-analysis; Ultrasound; Exposure-levels; Demographic-characteristics; Surveillance-programs
Luenda E. Charles, PhD, MPH, Biostatistics and Epidemiology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, HELD/BEB, MS L-4050, 1095 Willowdale Rd, Morgantown, WV 26505
Journal of Occupational and Environmental Medicine
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