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Lung cancer mortality in a combined cohort of North Carolina and South Carolina asbestos textile workers.
Elliott-L; Loomis-D; Dement-J; Hein-M; Richardson-D; Kuempel-E; Stayner-L
Occup Environ Med 2011Sep; 68(Suppl 1):A22
Objectives: Prior studies of asbestos textile workers in two US cohorts (North Carolina (NC) and South Carolina (SC)) found increased risk of lung cancer mortality with exposure to chrysotile asbestos. The risk, however, appeared to increase more steeply in SC, possibly due to differences in statistical methods and/or cohort defi nitions. The objective of this study was to investigate the exposure-disease relationship in a combined cohort, using equivalent inclusion criteria and analysis. Methods: Workers were included after 30 days of employment in a production job during qualifying years, and vital status ascertained through 2003 (2001 for SC). Standardised mortality ratios (SMR) were estimated using national and state-specifi c rates. Associations of lung cancer mortality with cumulative fi bre exposures (measured by phase contrast microscopy, lagged 10 years) were estimated by Poisson regression with adjustment for age, sex, race, birth cohort, decade of follow-up, and plant. Results: The cohort included 6136 workers, contributing 218 631 person-years of observation and 3356 deaths. Mortality from all causes and all cancers, especially lung cancer (SMR 1.93, 95% CI 1.73 to 2.15) was signifi cantly higher than expected. The relative rate for lung cancer was 1.11 (95% CI 1.06 to 1.16) at 100 fi bre-years/ml compared with 0 fi breyears/ ml. Stratifi cation showed different effects in SC (RR 1.65, 95% CI 1.42 to 1.92) than in NC (RR 1.12, 95% CI 1.06 to 1.19).
Asbestos-products; Humans; Men; Women; Carcinogens; Exposure-levels; Risk-factors; Lung-cancer; Lung; Pulmonary-disorders; Pulmonary-system; Pulmonary-system-disorders; Respiratory-system-disorders; Textile-workers; Mortality-rates; Morbidity-rates; Fibrous-dusts; Fibrous-bodies
Occupational and Environmental Medicine
NV; NE; NC; OH; IL
University of Nevada, Reno
Page last reviewed: May 17, 2019
Content source: National Institute for Occupational Safety and Health Education and Information Division