Fiber deposition in the human upper airways.
Proceedings of the Seventh International Aerosol Conference, September 10-15, 2006, St. Paul, Minnesota, USA.. Biswas P, Chen DR, Hering S, eds. Mount Laurel, NJ: American Association for Aerosol Research, 2006 Sep; :890-891
Fiber is a notorious occupational hazard. Many occupational diseases were found to be associated with the deposition of fibers in the human airway. For instance, the deposition of asbestos in the human lung increases the incidence of lung cancer, mesothelioma, and fibrosis. Numerous studies have reported the deposition of spherical particles in human airway replicas (Cheng et at. 1999,2001). However, very few studies to date have been conducted for fiber deposition in the human airway replica. This lack of information not only makes the nature of fiber deposition in the human airway to remain unknown, but also hampers the verification of the available lung deposition models for fiber. To fill this gap, fiber deposition experiments were carried out in our laboratory to investigate the effect of fiber dimension on the deposition pattern and deposition efficiency in the human upper airways replicas (nasal airway and oral airway). The use of human upper airways is due to the fact that the nasal airway is the major entry to the human respiratory tract and acts as a first line of defense, and the human oral airway is the main entrance for inhaled air when people are performing moderate to heavy work or exercise. Hence, the deposition fraction obtained in the human upper airways could directly indicate the remaining fraction of the inhaled fibers that enter the human lower airway - the deep lung.
Humans; Exposure-levels; Particulates; Fibrous-bodies; Models; Respiration; Pulmonary-function; Pulmonary-system; Diseases; Lung; Lung-disorders; Aerosols; Aerosol-particles; Hazards; Asbestos-fibers; Asbestosis;
Author Keywords: Fiber; Deposition; Human Airway
Biswas-P; Chen-DR; Hering-S
Proceedings of the Seventh International Aerosol Conference, September 10-15, 2006, St. Paul, Minnesota, USA.
Lovelace Biomedical & Environmental Research, Albuquerque, New Mexico