Computer simulation of ellipsoidal particle transport and deposition in human tracheobronchial tree with 3-D symmetric and asymmetric bifurcation model.
Tian-L; Ahmadi-G; Hopke-PK; Chen-Y-S
Proceedings of the Seventh International Aerosol Conference, September 10-15, 2006, St. Paul, Minnesota, USA.. Biswas P, Chen DR, Hering S, eds. Mount Laurel, NJ: American Association for Aerosol Research, 2006 Sep; :908-909
The study of particle transport in human airways has attracted much attention due to its significance in better understanding of personal exposure and for developing effective devices for inhalation drug delivery. While most of previous study was focused on spherical particles, many environmental particulate pollutants are non-spherical and are elongated particles and fibers. For example asbestos is know to be serious health hazard. In this study, computer simulations are conducted to investigate the transport and deposition of elongated ellipsoidal particles of various size, aspect ratio, and particle-to-fluid densities in human tracheobronchial bifurcation model under mild to moderate breathing conditions. Current study is focused on Generation 0 and 1 of the tracheobronchial tree as suggested by Weibel (1963) classification. The three dimensional airflow fields were first simulated. The ellipsoidal particle transport equation incorporated translational and rotational motion under the coupled effects of hydrodynamic drag force, shear induced lift force, gravitational force, and hydrodynamic torque. The simulation results provide an understanding of the motion of ellipsoidal particles in human tracheobronchial tree. The simulation result are compared with experimental data and discussed.
Humans; Exposure-levels; Inhalation-studies; Particulates; Fibrous-bodies; Asbestos-fibers; Models; Respiration; Pulmonary-function; Pulmonary-system;
Author Keywords: Ellipsoidal Particle; Fiber Deposition; Particle Deposition; Human Tracheobronchial Tree; Laminar; Turbulence
Biswas-P; Chen-DR; Hering-S
Proceedings of the Seventh International Aerosol Conference, September 10-15, 2006, St. Paul, Minnesota, USA.