Human nasal passage fibrous particle deposition: the influence of particle length, flow rate and passage geometry.
Wang-Z; Hopke-PK; Baron-PA; Ahmadi-G; Chen-Y-S; Deye-G; Su-W-C
Proceedings of the Seventh International Aerosol Conference, September 10-15, 2006, St. Paul, Minnesota, USA.. Biswas P, Chen DR, Hering S, eds. Mount Laurel, NJ: American Association for Aerosol Research, 2006 Sep; :911-912
The filtration efficiency of the nose during nasal inhalation determines the fraction of airborne particles reaching the lung. The information on the regional deposition will also be used to evaluate the toxicity of the inhaled fibrous particles. In this research, aerosols of glass fibers were passed into human nasal airway models to investigate the effect of particle length, flow rate and passage geometry on nasal deposition efficiency. Both total and regional deposition efficiencies in the nose were measured. A dielectrophoretic fiber classifier (Baron et aI., 1994; Wang et aI., 2005) was used to produce an aerosol with the fibers within a specific length range. The geometrical profiles of the human nasal airway were obtained by using magnetic resonance imaging (MRI) of human subjects. Gambit and Autodesk were used to fulfill the surface reconstruction of these models. Stereo lithography was used to construct the nasal airway models at Clarkson.
Filtration; Nasal-cavity; Inhalants; Airborne-particles; Particulates; Lung; Toxins; Models; Fibrous-glass;
Author Keywords: fiber; nasal passage; deposition
Biswas-P; Chen-DR; Hering-S
Proceedings of the Seventh International Aerosol Conference, September 10-15, 2006, St. Paul, Minnesota, USA.
Lovelace Biomedical & Environmental Research, Albuquerque, New Mexico