NIOSHTIC-2 Publications Search

Antimicrobial activity and biocompatibility of polyurethane--iodine complexes.

Luo J; Deng Y; Sun Y

J Bioact Compat Polym 2010 Mar; 25(2):185-206

https://doi.org/10.1177/0883911509359980

20044856

Polyurethane (PU), one of the most versatile biomedical materials, strongly binds iodine, one of the most effective antiseptics, through the formation of a charge-transfer complex. The PU-Iodine complexes were characterized with UV/Vis study and X-ray photoelectron spectroscopy (XPS) analysis. The new materials evoked potent antimicrobial activity against Gram-negative and Gram-positive bacteria (including methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus faecium, and bacterial spores), fungi, and viruses, as well as inhibited surface bacterial colonization and biofilm-formation. Based on the Kirby-Bauer test, the antimicrobial effects occurred through the slow release of iodine. The iodine release rate can be controlled by the preparation conditions of the PU-Iodine complex. Trypan blue exclusion analysis indicated that PU-Iodine has excellent mammalian cell viability. The PU-Iodine complexes have the potential for a wide range of medical, dental, and other related applications.

Bacteria; Bacterial-disease; Bacterial-infections; Bactericides; Microorganisms; Author Keywords: polyurethane; iodine; antimicrobial; biofilm-controlling; antiinfective; antibacterial; iodine release; controlled iodine release; biocompatible

Yuyu Sun, Biomedical Engineering Program, University of South Dakota, Vermillion, South Dakota 57107, USA

JBCPEV

7553-56-2

20100301

Journal Article

yuyu.sun@usd.edu

Grant

2010

Grant-Number-R03-OH-009325

2

0883-9115

Journal of Bioactive and Compatible Polymers

SD

University of South Dakota