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Antimicrobial activity and biocompatibility of polyurethane--iodine complexes.
Luo-J; Deng-Y; Sun-Y
J Bioact Compat Polym 2010 Mar; 25(2):185-206
Polyurethane (PU), one of the most versatile biomedical materials, strongly binds iodine, one of the most effective antiseptics, through the formation of a charge-transfer complex. The PU-Iodine complexes were characterized with UV/Vis study and X-ray photoelectron spectroscopy (XPS) analysis. The new materials evoked potent antimicrobial activity against Gram-negative and Gram-positive bacteria (including methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus faecium, and bacterial spores), fungi, and viruses, as well as inhibited surface bacterial colonization and biofilm-formation. Based on the Kirby-Bauer test, the antimicrobial effects occurred through the slow release of iodine. The iodine release rate can be controlled by the preparation conditions of the PU-Iodine complex. Trypan blue exclusion analysis indicated that PU-Iodine has excellent mammalian cell viability. The PU-Iodine complexes have the potential for a wide range of medical, dental, and other related applications.
Bacteria; Bacterial-disease; Bacterial-infections; Bactericides; Microorganisms; Author Keywords: polyurethane; iodine; antimicrobial; biofilm-controlling; antiinfective; antibacterial; iodine release; controlled iodine release; biocompatible
Yuyu Sun, Biomedical Engineering Program, University of South Dakota, Vermillion, South Dakota 57107, USA
Issue of Publication
Journal of Bioactive and Compatible Polymers
University of South Dakota
Page last reviewed: April 12, 2019
Content source: National Institute for Occupational Safety and Health Education and Information Division