Health care worker exposures to the antibacterial agent triclosan.
MacIsaac-JK; Gerona-RR; Blanc-PD; Apatira-L; Friesen-MW; Coppolino-M; Janssen-S
J Occup Environ Med 2014 Aug; 56(8):834-839
Objective: We sought to quantify absorption of triclosan, a potential endocrine disruptor, in health care workers with occupational exposure to soap containing this chemical. Methods: A cross-sectional convenience sample of two groups of 38 health care workers at separate inpatient medical centers: hospital 1 uses 0.3% triclosan soap in all patient care areas; hospital 2 does not use triclosan-containing products. Additional exposure to triclosan-containing personal care products was assessed through a structured questionnaire. Urine triclosan was quantified and the occupational contribution estimated through regression modeling. Results: Occupational exposure accounted for an incremental triclosan burden of 206 ng/mL (P = 0.02), while triclosan-containing toothpaste use was associated with 146 ng/mL higher levels (P < 0.001). Conclusions: Use of triclosan-containing antibacterial soaps in health care settings represents a substantial and potentially biologically relevant source of occupational triclosan exposure.
Humans; Men; Women; Chemical-properties; Chemical-reactions; Chemical-composition; Exposure-limits; Risk-factors; Endocrine-system-disorders; Health-care-personnel; Soap-products; Medical-personnel; Medical-facilities; Questionnaires; Urinalysis; Models; Bacteria; Bactericides; Biological-effects
Julia K. MacIsaac, MD, MPH, Division of Occupational and Environmental Medicine, Department of Medicine, University of California, San Francisco, 1600 Divisadero St Suite 1661, San Francisco, CA 94115
Journal of Occupational and Environmental Medicine
University of California, Berkeley