Recovery of vascular function after exposure to a single bout of segmental vibration.
Krajnak K; Waugh S; Miller GR; Johnson C
J Toxicol Environ Health, A 2014 Sep; 77(17):1061-1069
Work rotation schedules may be used to reduce the negative effects of vibration on vascular function. This study determined how long it takes vascular function to recover after a single exposure to vibration in rats (125 Hz, acceleration 5g). The responsiveness of rat-tail arteries to the vasoconstricting factor UK14304, an á2C-adrenoreceptor agonist, and the vasodilating factor acetylcholine (ACh) were measured ex vivo 1, 2, 7, or 9 d after exposure to a single bout of vibration. Vasoconstriction induced by UK14304 returned to control levels after 1 d of recovery. However, re-dilation induced by ACh did not return to baseline until after 9 d of recovery. Exposure to vibration exerted prolonged effects on peripheral vascular function, and altered vascular responses to a subsequent exposure. To optimize the positive results of work rotation schedules, it is suggested that studies assessing recovery of vascular function after exposure to a single bout of vibration be performed in humans.
Vibration; Hand-tools; Repetitive-work; Risk-factors; Biological-effects; Biological-factors; Biological-monitoring; Biomechanical-modeling; Biomechanics; Exposure-assessment; Exposure-levels; Injury-prevention; Laboratory-animals; Laboratory-techniques; Mathematical-models; Measurement-equipment; Physiological-effects; Physiological-response; Quantitative-analysis; Statistical-analysis; Tools; Vasomotor-system; Vasomotor-system-disorders; Vibration-effects; Vibration-exposure
Kristine Krajnak, Ph.D, NIOSH, 1095 Willowdale Rd, MS2027, Morgantown, WV 26505
Journal of Toxicology and Environmental Health, Part A: Current Issues