Immunoglobulin genes influence the magnitude of humoral immunity to cytomegalovirus glycoprotein B.
Pandey-JP; Kistner-Griffin-E; Radwan-FF; Kaur-N; Namboodiri-AM; Black-L; Butler-MA; Carreon-T; Ruder-AM
J Infect Dis 2014 Dec; 210(11):1823-1826
Human cytomegalovirus (HCMV) is a risk factor for many human diseases, but among exposed individuals, not everyone is equally likely to develop HCMV-spurred diseases, implying the presence of host genetic factors that might modulate immunity to this virus. Here, we show that antibody responsiveness to HCMV glycoprotein B (gB) is significantly associated with particular immunoglobulin GM (y marker) genotypes: Anti-HCMV gB antibody levels were the highest in GM 17/17 homozygotes, intermediate in GM 3/17 heterozygotes, and the lowest in GM 3/3 homozygotes (28.2, 19.0, and 8.1 ug/mL, respectively; p=0.014). These findings provide mechanistic insights in the etiopathogenesis of HCMV-spurred diseases.
Humans; Men; Women; Risk-factors; Viral-diseases; Viral-infections; Exposure-levels; Diseases; Disease-vectors; Genetic-factors; Antibody-response; Morbidity-rates; Mortality-rates; Autoimmunity; Malignancy; Immune-system; Immune-reaction;
Author Keywords: GM allotypes; humoral immunity; human cytomegalovirus; glycoprotein B; candidate genes
Dr. Janardan P. Pandey, Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, South Carolina, SC 29425
Research Tools and Approaches: Exposure Assessment Methods; Healthcare and Social Assistance; Manufacturing; Services
The Journal of Infectious Diseases