Inverse association between toenail arsenic and body mass index in a population of welders.
Grashow-R; Zhang-J; Fang-SC; Weisskopf-MG; Christiani-DC; Kile-ML; Cavallari-JM
Environ Res 2014 May; 131:131-133
Recent data show that arsenic may play a role in obesity-related diseases. However, urinary arsenic studies report an inverse association between arsenic level and body mass index (BMI). We explored whether toenail arsenic, a long-term exposure measure, was associated with BMI in 74 welders with known arsenic exposure. BMI showed significant inverse associations with toenail arsenic (p=0.01), which persisted in models adjusted for demographics, diet and work history. It is unclear whether low arsenic biomarker concentrations in high BMI subjects truly reflect lower exposures, or instead reflect internal or metabolic changes that alter arsenic metabolism and tissue deposition.
Arsenic-compounds; Humans; Men; Women; Welding; Welders; Body-weight; Weight-factors; Urinalysis; Exposure-levels; Risk-factors; Models; Demographic-characteristics; Biomarkers; Metabolic-rate; Metabolism;
Author Keywords: Arsenic; Toenail; BMI; Welding fume; Metals; Occupational health
Rachel Grashow, Department of Environmental Health, Harvard School of Public Health, Landmark Center, 401 Park Drive, 3rd Floor, Boston, MA 02215
Cooperative Agreement; Construction
CPWR - The Center for Construction Research and Training, Silver Spring, Maryland