NIOSHTIC-2 Publications Search

Lung macrophages "digest" carbon nanotubes using a superoxide/peroxynitrite oxidative pathway.

Authors
Kagan-VE; Kaprolov-AA; St. Croix-CM; Watkins-SC; Kisin-ER; Kotchey-GP; Balasubramanian-K; Vlasova-II; Yu-J; Kim-K; Seo-W; Mallampalli-RK; Star-A; Shvedova-AA
Source
ACS Nano 2014 Jun; 8(6):5610-5621
NIOSHTIC No.
20044541
Abstract
In contrast to short-lived neutrophils, macrophages display persistent presence in the lung of animals after pulmonary exposure to carbon nanotubes. While effective in the clearance of bacterial pathogens and injured host cells, the ability of macrophages to "digest" carbonaceous nanoparticles has not been documented. Here, we used chemical, biochemical, and cell and animal models and demonstrated oxidative biodegradation of oxidatively functionalized single-walled carbon nanotubes via superoxide/ NO* f peroxynitrite-driven oxidative pathways of activated macrophages facilitating clearance of nanoparticles from the lung.
Keywords
Lung; Animals; Laboratory-animals; Pulmonary-function; Pulmonary-system; Pulmonary-system-disorders; Pulmonary-disorders; Exposure-levels; Biochemical-analysis; Cell-cultures; Models; Nanotechnology; Biodegradation; Author Keywords: single-walled carbon nanotubes; peroxynitrite; biodegradation; lung
CODEN
ANCAC3
Publication Date
20140624
Document Type
Journal Article
Email Address
kagan@pitt.edu
Funding Type
Grant
Fiscal Year
2014
Identifying No.
Grant-Number-R01-OH-008282
Issue of Publication
6
ISSN
1936-0851
NIOSH Division
HELD
Priority Area
Mining; Manufacturing
Source Name
American Chemical Society Nano
State
PA; WV
Performing Organization
University of Pittsburgh at Pittsburgh
Page last reviewed: April 12, 2019
Content source: National Institute for Occupational Safety and Health Education and Information Division