NIOSHTIC-2 Publications Search
Decline in the prevalence of airflow limitation in US adults aged 40-79: NHANES, 1988-1994 and 2007-2010.
Doney-B; Hnizdo-E; Dillon-C; Paulose-Ram-R; Tilert-T; Wolz-M
Am J Respir Crit Care Med 2013 May; 187(Meeting Abstracts):A3642
Rationale: The objective of this study was to investigate changes in the prevalence of airflow limitation for the US adult population between 1988-1994 and 2007-2010. Methods: Spirometry data from the National Health and Nutrition Examination Surveys, nationally representative surveys of the non-institutionalized US population, conducted during 1988-1994 and 2007-2010 were analyzed. The prevalence of airflow limitation was estimated in adults aged 40-79 using pre-bronchodilator spirometry test results based on criteria from the American Thoracic Society (ATS) and a modification of the Global Initiative for Obstructive Lung Disease (GOLD) criteria. Airflow limitation was defined as forced expiratory volume in 1 second (FEV1)/forced vital capacity (FVC) < lower limit of normal (LLN) (ATS) and as FEV1/FVC < 70% (GOLD), respectively. Cut points for moderate or worse airflow limitation were defined as FEV1/FVC < LLN plus FEV1 < 70% predicted (ATS) or FEV1 /FVC < 70% plus FEV1 < 80% predicted (GOLD). Results: Based on ATS criteria, the overall age-adjusted prevalence of airflow limitation among adults 40-79 years decreased from 19.8% (SE 0.9) in 1988-1994 to 14.5% (SE 0.7) in 2007-2010 (p<0.01). Significant decreases between the two survey periods were seen for those aged 60-69 years (24.4% vs. 15.4%; p<0.01), 70-79 years (24.4% vs. 17.2%; p<0.05), for men (22.6% vs. 15.3%; p<0.01) and women (17.5% vs. 13.8%; p<0.05), and for non-Hispanic white adults (21.2% vs. 15.8%; p<0.01). Using the modified GOLD criteria, the overall age-adjusted prevalence of airflow limitation decreased from 22.1% (SE 0.7) to 19.9% (SE 1.0) (p<0.05). Significant decreases between the two survey periods were only seen among men (27.6% vs. 23.9%; p<0.05) and Mexican-American adults (15.1% vs. 10.3%; p<0.05). The prevalence of moderate or worse airflow limitation decreased from 7.2% (SE 0.5) to 4.3% (SE 0.4) (p<0.01) based on the ATS criteria and from 11.7% (SE 0.5) to 9.0% (SE 0.6) (p<0.01) based on the modified GOLD criteria. During 2007-2010, an estimated 5.4 million adults aged 40-79 years had moderate or worse airflow limitation based on the ATS criteria. Conclusions: The overall prevalence of airflow limitation in US adults decreased from 1988-1994 to 2007-2010 based on both the ATS and modified GOLD criteria. Significant declines in the prevalence of airflow limitation for the various age, gender, and race-ethnic groups varied by the criteria used to define airflow limitation.
Respiratory-system-disorders; Pulmonary-system-disorders; Lung-disease; Airway-obstruction; Surveillance-programs; Health-surveys; Pulmonary-function-tests; Spirometry; Vital-capacity; Age-groups; Humans; Men; Women; Racial-factors
B. Doney, National Institute for Occupational Safety and Health, Morgantown, WV
American Journal of Respiratory and Critical Care Medicine