Methamphetamine-induced toxicity: an updated review on issues related to hyperthermia.
Matsumoto-RR; Seminerio-MJ; Turner-RC; Robson-MJ; Nguyen-L; Miller-DB; O'Callaghan-JP
Pharmacol Ther 2014 Oct; 144(1):28-40
Reports of methamphetamine-related emergency room visits suggest that elevated body temperature is a universal presenting symptom, with lethal overdoses generally associated with extreme hyperthermia. This review summarizes the available information on methamphetamine toxicity as it pertains to elevations in body temperature. First, a brief overview of thermoregulatory mechanisms is presented. Next, central and peripheral targets that have been considered for potential involvement in methamphetamine hyperthermia are discussed. Finally, future areas of investigation are proposed, as further studies are needed to provide greater insight into the mechanisms that mediate the alterations in body temperature elicited by methamphetamine.
Drugs; Drug-abuse; Body-temperature; Mortality-surveys; Morbidity-rates; Hyperthermia; Toxic-effects; Toxic-dose; Central-nervous-system; Proteins;
Author Keywords: Autonomic nervous system; Hyperthermia; Methamphetamine; Reactive oxygen species; Thermoregulation; Toxicity
Rae R. Matsumoto, West Virginia University, School of Pharmacy, One Medical Center Drive, Morgantown, WV 26506
Pharmacology & Therapeutics