Lysophosphatidic acid and apolipoprotein A1 predict increased risk of developing World Trade Center-lung injury: a nested case-control study.
Tsukiji-J; Cho-SJ; Echevarria-GC; Kwon-S; Joseph-P; Schenck-EJ; Naveed-B; Prezant-DJ; Rom-WN; Schmidt-AM; Weiden-MD; Nolan-A
Biomarkers 2014 Mar; 19(2):159-165
RATIONALE: Metabolic syndrome, inflammatory and vascular injury markers measured in serum after World Trade Center (WTC) exposures predict abnormal FEV1. We hypothesized that elevated LPA levels predict FEV1 < LLN. METHODS: Nested case-control study of WTC-exposed firefighters. Cases had FEV1 < LLN. Controls derived from the baseline cohort. Demographics, pulmonary function, serum lipids, LPA and ApoA1 were measured. RESULTS: LPA and ApoA1 levels were higher in cases than controls and predictive of case status. LPA increased the odds by 13% while ApoA1 increased the odds by 29% of an FEV1 < LLN in a multivariable model. CONCLUSIONS: Elevated LPA and ApoA1 are predictive of a significantly increased risk of developing an FEV1 < LLN.
Emergency-response; Emergency-responders; Fire-fighters; Respiratory-system-disorders; Pulmonary-system-disorders; Pulmonary-function; Pulmonary-function-tests; Lung-disorders; Lung-function; Biomarkers; Airway-obstruction; Airborne-dusts; Airborne-particles; Particulate-dust; Particulates; Immunoglobulins; Serology; Risk-factors;
Author Keywords: Biomarkers; dyslipidemia and occupational exposure; World Trade Center
Anna Nolan, MD, MS, Assistant Professor of Medicine and Environmental Medicine, Division of Pulmonary, Critical Care and Sleep, NYU School of Medicine, New Bellevue, 7N Room 24, 462 1st Avenue, New York, NY 10016, USA
Cooperative-Agreement-Number-U10-OH-008243; Cooperative-Agreement-Number-U10-OH-008242; M052014
New York City Fire Department