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Concentrations and stability of methyl methacrylate, glutaraldehyde, formaldehyde and nickel sulfate in commercial patch test allergen preparations.

Authors
Siegel-PD; Fowler-JF; Law-BF; Warshaw-EM; Taylor-JS
Source
Contact Dermatitis 2014 May; 70(5):309-315
NIOSHTIC No.
20044222
Abstract
BACKGROUND: Epicutaneous patch tests are used to reproduce allergy and diagnose allergic contact dermatitis. Reliable allergen test preparations are required. OBJECTIVES: The purpose of the present study was to measure the actual concentrations of nickel(II) sulfate hexahydrate (NiSO4 ), methyl methacrylate, formaldehyde, and glutaraldehyde, and to compare them with the labelled concentrations, in commercial patch test allergen preparations found in dermatology clinics where patch testing is routinely performed. MATERIALS AND METHODS: The commercial in-date and out-of-date patch test allergen preparations concentrations of NiSO4 , methyl methacrylate, formaldehyde and glutaraldehyde from one to three participating clinics were analysed with chromatographic or wet chemical techniques. RESULTS: NiSO4 and formaldehyde concentrations were at or above the labelled concentrations; however, formaldehyde loss occurred with storage. NiSO4 particulate was uniformly distributed throughout the petrolatum. 'In-use' methyl methacrylate reagent syringes all contained
Keywords
Allergies; Allergens; Skin; Skin-exposure; Skin-tests; Dermatitis; Nickel-compounds; Formaldehydes; Patch-tests; Author Keywords: concentration and stability; formaldehyde; glutaraldehyde; methyl methacrylate; nickel sulfate; patch test allergens
Contact
Paul D. Siegel, Bioorganic Chemistry, ACIB/HELD/NIOSH/CDC, 1095 Willowdale Road, Morgantown, WV 26505-2888
CODEN
CODEDG
CAS No.
7440-02-0; 7786-81-4; 50-00-0; 111-30-8
Publication Date
20140501
Document Type
Journal Article
Email Address
psiegel@cdc.gov
Fiscal Year
2014
Identifying No.
M052014
Issue of Publication
5
ISSN
0105-1873
NIOSH Division
HELD
Source Name
Contact Dermatitis
State
WV; KY; MN; OH
Page last reviewed: March 11, 2019
Content source: National Institute for Occupational Safety and Health Education and Information Division