Genetic variants in the major histocompatibility complex class I and class II genes are associated with diisocyanate-induced asthma.
Yucesoy-B; Johnson-VJ; Lummus-ZL; Kashon-ML; Rao-M; Bannerman-Thompson-H; Frye-B; Wang-W; Gautrin-D; Cartier-A; Boulet-L-P; Sastre-J; Quirce-S; Tarlo-SM; Germolec-DR; Luster-MI; Bernstein-DI
J Occup Environ Med 2014 Apr; 56(4):382-387
To investigate the association between single nucleotide polymorphisms (SNPs) located across the major histocompatibility complex and susceptibility to diisocyanate-induced asthma (DA). Methods: The study population consisted of 140 diisocyanate-exposed workers. Genotyping was performed using the Illumina GoldenGate major histocompatibility complex panels. Results: The HLA-E rs1573294 and HLA-DPB1 rs928976 SNPs were associated with an increased risk of DA under dominant (odds ratio [OR], 6.27; 95% confidence interval [CI], 2.37 to 16.6; OR, 2.79, 95% CI, 0.99 to 7.81, respectively) and recessive genetic models (OR, 6.27, 95% CI, 1.63 to 24.13; OR, 10.10, 95% CI, 3.16 to 32.33, respectively). The HLA-B rs1811197, HLA-DOA rs3128935, and HLA-DQA2 rs7773955 SNPs conferred an increased risk of DA in a dominant model (OR, 7.64, 95% CI, 2.25 to 26.00; OR, 19.69, 95% CI, 2.89 to 135.25; OR, 8.43, 95% CI, 3.03 to 23.48, respectively). Conclusion: These results suggest that genetic variations within HLA genes play a role in DA risk.
Genes; Bronchial-asthma; Respiratory-system-disorders; Pulmonary-function; Pulmonary-system; Pulmonary-system-disorders; Statistical-analysis; Polyurethane-foams; Paints; Exposure-levels; Risk-factors
Berran Yucesoy, PhD, Division of Immunology, Allergy and Rheumatology, College of Medicine, University of Cincinnati, Cincinnati, OH 45267-0563; Health Effects Laboratory Division, NIOSH/CDC, Morgantown, WV 26505
26471-62-5; 101-68-8; 822-06-0
Healthcare and Social Assistance; Services
Journal of Occupational and Environmental Medicine
University of Cincinnati