Carbon nanotubes are toxic in experimental models: what's next, who's being exposed, and should we be concerned?
Toxicologist 2014 Mar; 138(1):4
Engineered nanomaterials have vast potential with applications in medicine, electronics, and composites. Carbon nanotubes (CNT) represent one such material with broad applications, but this material also has the propensity for significant toxicity. Toxicities include pulmonary and systemic inflammation, fibrosis, immunosuppression, and cardiovascular dysfunction, and evidence is growing that CNT may have properties that influence carcinogenicity. Over the past decade there has been a significant investment in research to examine the in vivo and in vitro toxicity of CNT. Conversely, very little is known about the exposure level and chemical and physical properties of airborne CNT that humans are exposed to, especially in the workplace. These deficiencies make the interpretation of the vast number of experimental studies to human relevance difficult. Initial findings from epidemiological studies of workers handling engineered nanomaterials, recent advancements in detailed facility exposure assessment, pertinent in vivo toxicology studies with dosimetry-based human health implications, regulatory aspects, and risk assessment based on results from animal inhalation studies will be included. The outcome of this session is to provide the most recent human exposure assessment and epidemiological findings and to gather perspective on in vivo toxicology studies involving risk estimates and potential carcinogenicity. This data should have direct influence on the course of newly designed studies and add perspective on previous studies of CNT-induced toxicity.
Toxicology; Nanotechnology; Pulmonary-disorders; Pulmonary-function; Pulmonary-system; Pulmonary-system-disorders; Respiratory-infections; Fibrosis; Immune-system; Cardiovascular-system-disease; Cardiovascular-system-disorders; Carcinogens; In-vitro-study; In-vivo-study; Airborne-dusts; Airborne-particles; Exposure-levels; Epidemiology
The Toxicologist. Society of Toxicology 53rd Annual Meeting and ToxExpo, March 23-27, 2014, Phoenix, Arizona