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Coronary artery disease and cancer mortality in a cohort of workers exposed to vinyl chloride, carbon disulfide, rotating shift work, and o-toluidine at a chemical manufacturing plant.
Carreon T; Hein MJ; Hanley KW; Viet SM; Ruder AM
Am J Ind Med 2014 Apr; 57(4):398-411
BACKGROUND: We updated through 2007 the mortality experience of 1,874 workers employed at a New York State chemical manufacturing plant between 1946 and 2006. METHODS: Reassessed exposures to vinyl chloride, carbon disulfide, and shift work and categories of o-toluidine exposure were based on year, department and job title. Standardized mortality ratios (SMR) compared mortality to that of the US population. Internal comparisons used directly standardized rate ratios. RESULTS: Hepatobiliary cancer mortality was elevated among workers ever exposed to vinyl chloride (SMR = 3.80, 95% confidence interval 1.89-6.80); directly standardized rates increased with increasing vinyl chloride exposure duration. No increase in non-Hodgkin lymphoma mortality was observed with vinyl chloride and shift work exposures. Internal comparisons showed increased coronary artery disease mortality among long-term workers exposed to carbon disulfide and shift work for 4 years or more. CONCLUSIONS: Excess coronary artery disease mortality confirms earlier results; further investigation is needed to understand risk factors.
Chemical-manufacturing-industry; Chemical-industry-workers; Mortality-data; Mortality-rates; Chlorides; Sulfides; Toluidines; Shift-work; Shift-workers; Cancer; Cardiac-function; Cardiovascular-disease; Cardiovascular-system-disease; Liver-cancer; Biliary-system-disorders; Hepatotoxins; Author Keywords: cohort mortality; chemical manufacturing; vinyl chloride; carbon disulfide; o-toluidine; shift work; cancer; coronary artery disease
Dr.Tania Carreon, PhD, Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, 4676 Columbia Pkwy, Mailstop R-5, Cincinnati, OH 45226
75-01-4; 75-15-0; 95-53-4
Issue of Publication
American Journal of Industrial Medicine
Page last reviewed: April 1, 2022
Content source: National Institute for Occupational Safety and Health Education and Information Division