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Presence of organophosphorus pesticide oxygen analogs in air samples.

Armstrong JL; Fenske RA; Yost MG; Galvin K; Tchong-French M; Yu J
Atmos Environ 2013 Feb; 66:145-150
A number of recent toxicity studies have highlighted the increased potency of oxygen analogs (oxons) of several organophosphorus (OP) pesticides. These findings were a major concern after environmental oxons were identified in environmental samples from air and surfaces following agricultural spray applications in California and Washington State. This paper reports on the validity of oxygen analog measurements in air samples for the OP pesticide, chlorpyrifos. Controlled environmental and laboratory experiments were used to examine artificial formation of chlorpyrifos-oxon using OSHA Versatile Sampling (OVS) tubes as recommended by NIOSH method 5600. Additionally, we compared expected chlorpyrifos-oxon attributable to artificial transformation to observed chlorpyrifos-oxon in field samples from a 2008 Washington State Department of Health air monitoring study using non-parametric statistical methods. The amount of artificially transformed oxon was then modeled to determine the amount of oxon present in the environment. Toxicity equivalency factors (TEFs) for chlorpyrifos-oxon were used to calculate chlorpyrifos-equivalent air concentrations. The results demonstrate that the NIOSH-recommended sampling matrix (OVS tubes with XAD-2 resin) was found to artificially transform up to 30% of chlorpyrifos to chlorpyrifos-oxon, with higher percentages at lower concentrations (<30 ng m -3) typical of ambient or residential levels. Overall, the 2008 study data had significantly greater oxon than expected by artificial transformation, but the exact amount of environmental oxon in air remains difficult to quantify with the current sampling method. Failure to conduct laboratory analysis for chlorpyrifos-oxon may result in underestimation of total pesticide concentration when using XAD-2 resin matrices for occupational or residential sampling. Alternative methods that can accurately measure both OP pesticides and their oxygen analogs should be used for air sampling, and a toxicity equivalent factor approach should be used to determine potential health risks from exposures.
Air-sampling; Organo-phosphorus-compounds; Organo-phosphorus-pesticides; Pesticides; Pesticides-and-agricultural-chemicals; Toxins; Agricultural-industry; Agriculture; Agricultural-chemicals; Monitoring-systems; Adsorbents; Analytical-processes; Chemical-composition; Chemical-properties; Analytical-methods; Environmental-contamination; Air-sampling-techniques; Measurement-equipment; Equipment-reliability; Laboratory-testing; Author Keywords: Air monitoring; Exposure; Organophosphorus pesticides; Oxon; Toxicity equivalent concentration; XAD resin
Jenna L. Armstrong, Department of Environmental and Occupational Health Sciences, University of Washington School of Public Health, Seattle, WA 98105
7782-44-7; 2921-88-2
Publication Date
Document Type
Journal Article
Email Address
Funding Type
Grant; Cooperative Agreement
Fiscal Year
Identifying No.
Grant-Number-T42-OH-008433; Cooperative-Agreement-Number-U54-OH-007544
Priority Area
Agriculture, Forestry and Fishing
Source Name
Atmospheric Environment
Performing Organization
University of Washington
Page last reviewed: January 29, 2021
Content source: National Institute for Occupational Safety and Health Education and Information Division